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Antitumor effect of a novel HSP90 inhibitor in esophageal cancer cells

Research Project

Project/Area Number 24591964
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionKawasaki Medical School

Principal Investigator

YAMATSUJI Tomoki  川崎医科大学, 医学部, 准教授 (40379730)

Co-Investigator(Kenkyū-buntansha) NAOMOTO Yoshio  川崎医科大学, 医学部, 教授 (00237190)
FUKAZAWA Takuya  川崎医科大学, 医学部, 講師 (20379845)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords食道外科学 / 食道癌 / HSP90阻害剤 / AUY-922
Outline of Final Research Achievements

We investigated the antitumor effects of a novel HSP90 inhibitor, AUY922, in esophageal squamous cancer cells (ESCC). Four ESCC cell lines (TE-1, TE-4, TE-8, TE-10) were examined. AUY922 inhibited the proliferation of ESCC, particularly in PTEN-null TE-4 cells with a 2-3 times lower IC50 than the other cell lines. Western blot analysis showed that PTEN-null TE-4 cells showed higher Akt activity, which contribute to cell proliferation and survival. AUY922 suppressed the activity of Akt in TE-4 but not in PTEN-proficient TE-10 cells. AUY922 exhibits a strong antiproliferative effect, revealing its potential as a novel therapeutic alternative to current ESCC treatment. The effect may be improved further by impeding PTEN expression.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2015 2014 2013 2012 Other

All Journal Article (5 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] HSP90阻害剤を用いた難治性消化器癌に対する新規分子標的治療法の開発2014

    • Author(s)
      山辻知樹
    • Journal Title

      川崎医学会誌

      Volume: 40-補遺号 Pages: 53-53

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Antiproliferative effect of the HSP90 inhibitor NVP-AUY922 is determined by the expression of PTEN in esophageal cancer.2013

    • Author(s)
      Bao XH, Takaoka M, Hao HF, Fukazawa T, Yamatsuji T, Sakurama K, Takigawa N, Nakajima M, Fujiwara T, Naomoto Y
    • Journal Title

      Oncology Reports

      Volume: 29(1) Pages: 45-50

    • Related Report
      2013 Research-status Report
  • [Journal Article] Sasaki A. Novel HSP90 inhibitor NVP-AUY922 enhances the anti-tumor effect of temsirolimus against oral squamous cell carcinoma.2013

    • Author(s)
      Okui T, Shimo T, Fukazawa T, Mohammad Monsur Hassan N, Honami T, Ibaragi S, Takaoka M, Naomoto Y
    • Journal Title

      Current Cancer Drug Targets

      Volume: 13(3) Pages: 289-299

    • Related Report
      2013 Research-status Report
  • [Journal Article] Antiproliferative effect of a novel mTOR inhibitor temsirolimus contributes to the prolonged survival of orthotopic esophageal cancer-bearing mice.2013

    • Author(s)
      Nishikawa T, Takaoka M, Ohara T, Tomono Y, Hao H, Bao X, Fukazawa T, Wang Z, Sakurama K, Fujiwara Y, Motoki T, Shirakawa Y, Yamatsuji T, Tanaka N, Fujiwara T, Naomoto Y
    • Journal Title

      Cancer biology & therapy

      Volume: 14(3) Pages: 230-236

    • NAID

      120005324790

    • Related Report
      2013 Research-status Report
  • [Journal Article] Antiproliferative effect of the HSP90 inhibitor NVP-AUY922 is determined by the expression of PTEN in esophageal cancer2012

    • Author(s)
      Bao XH, Fukazawa T, Yamatsuji T, Naomoto Y.et al.
    • Journal Title

      Oncology Report

      Volume: 29 Issue: 1 Pages: 45-50

    • DOI

      10.3892/or.2012.2074

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Esophageal cancer exhibits a resistance to the chemical inhibition of IGF-1R with a maintained Ras-MAPK activity2015

    • Author(s)
      Munenori Takaoka, XiaoHong Bao, Huifang Hao, Naomasa Ishida, Takuya Fukazawa, Tomoki Yamatsuji, Minoru Haisa, Yoshio Naomoto
    • Organizer
      American Association for Cancer Research 2015
    • Place of Presentation
      Philadelphia, Pennsylvania,USA(Pannsylvania Convention Center)
    • Year and Date
      2015-04-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] HSP90阻害剤を用いた難治性消化器癌に対する新規分子標的治療法の開発2014

    • Author(s)
      山辻知樹
    • Organizer
      第5回川崎医科大学学術集会
    • Place of Presentation
      岡山県倉敷市(川崎医科大学)
    • Year and Date
      2014-08-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] HSP90阻害剤NVP-AUY922による食道癌にたいする抗腫瘍効果はPTENの発現により変化する

    • Author(s)
      高岡宗徳、深澤拓也、山辻知樹、猶本良夫ほか
    • Organizer
      第66回日本食道学会学術集会
    • Place of Presentation
      長野県軽井沢
    • Related Report
      2012 Research-status Report
  • [Presentation] HSP90 inhibitor NVP-AUY922 exhibits the potent antiproliferative effect in gastrointestinal cancer cells with a lack of PTEN expression.

    • Author(s)
      Takaoka M, Fukazawa T, Yamatsuji T, Naomoto Y.et al.
    • Organizer
      AACR Annual Meeting 2012.
    • Place of Presentation
      米国シカゴ
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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