Project/Area Number |
24591964
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
|
Research Institution | Kawasaki Medical School |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
NAOMOTO Yoshio 川崎医科大学, 医学部, 教授 (00237190)
FUKAZAWA Takuya 川崎医科大学, 医学部, 講師 (20379845)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 食道外科学 / 食道癌 / HSP90阻害剤 / AUY-922 |
Outline of Final Research Achievements |
We investigated the antitumor effects of a novel HSP90 inhibitor, AUY922, in esophageal squamous cancer cells (ESCC). Four ESCC cell lines (TE-1, TE-4, TE-8, TE-10) were examined. AUY922 inhibited the proliferation of ESCC, particularly in PTEN-null TE-4 cells with a 2-3 times lower IC50 than the other cell lines. Western blot analysis showed that PTEN-null TE-4 cells showed higher Akt activity, which contribute to cell proliferation and survival. AUY922 suppressed the activity of Akt in TE-4 but not in PTEN-proficient TE-10 cells. AUY922 exhibits a strong antiproliferative effect, revealing its potential as a novel therapeutic alternative to current ESCC treatment. The effect may be improved further by impeding PTEN expression.
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