Antitumor effect of a novel HSP90 inhibitor in esophageal cancer cells
Project/Area Number |
24591964
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Kawasaki Medical School |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
NAOMOTO Yoshio 川崎医科大学, 医学部, 教授 (00237190)
FUKAZAWA Takuya 川崎医科大学, 医学部, 講師 (20379845)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 食道外科学 / 食道癌 / HSP90阻害剤 / AUY-922 |
Outline of Final Research Achievements |
We investigated the antitumor effects of a novel HSP90 inhibitor, AUY922, in esophageal squamous cancer cells (ESCC). Four ESCC cell lines (TE-1, TE-4, TE-8, TE-10) were examined. AUY922 inhibited the proliferation of ESCC, particularly in PTEN-null TE-4 cells with a 2-3 times lower IC50 than the other cell lines. Western blot analysis showed that PTEN-null TE-4 cells showed higher Akt activity, which contribute to cell proliferation and survival. AUY922 suppressed the activity of Akt in TE-4 but not in PTEN-proficient TE-10 cells. AUY922 exhibits a strong antiproliferative effect, revealing its potential as a novel therapeutic alternative to current ESCC treatment. The effect may be improved further by impeding PTEN expression.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Antiproliferative effect of a novel mTOR inhibitor temsirolimus contributes to the prolonged survival of orthotopic esophageal cancer-bearing mice.2013
Author(s)
Nishikawa T, Takaoka M, Ohara T, Tomono Y, Hao H, Bao X, Fukazawa T, Wang Z, Sakurama K, Fujiwara Y, Motoki T, Shirakawa Y, Yamatsuji T, Tanaka N, Fujiwara T, Naomoto Y
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Journal Title
Cancer biology & therapy
Volume: 14(3)
Pages: 230-236
NAID
Related Report
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