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Decion of micrometastases in digestive system cancer and its clinical application

Research Project

Project/Area Number 24591967
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionHokkaido University

Principal Investigator

Hideyasu Sakihama  北海道大学, 医学研究科, 客員研究員 (50533676)

Co-Investigator(Kenkyū-buntansha) 尾崎 倫孝  北海道大学, 保健科学研究院, 教授 (80256510)
神山 俊哉  北海道大学, 医学研究科, 准教授 (80322816)
Project Period (FY) 2012-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords循環腫瘍細胞 / 骨髄腫瘍細胞 / 微小転移 / 予後 / 消化器癌 / 治療方針
Outline of Final Research Achievements

The purposes of the study are to detect circulating tumor cells (CTC) and disseminated tumor cells (DTC) in digestive system cancer and to examine how we apply into the clinical settings.
Preoperative positive rates of CTC and DTC in colon cancer patients were 23% and 26%,respectively. There is a significant higher incidence of postoperative recurrence and cancer related death in patients with CTC positive compared with in negative patients.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (13 results)

All 2017 2016 2014 2013 2012

All Presentation (13 results)

  • [Presentation] 大腸癌の循環腫瘍細胞と骨髄腫瘍細胞~特にstage2再発症例からみた臨床応用の可能性について~2017

    • Author(s)
      崎浜 秀康
    • Organizer
      第13回 日本消化管学会総会学術集会
    • Place of Presentation
      名古屋国際会議場(愛知県・名古屋市)
    • Year and Date
      2017-02-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] EMTに着目した胃癌の循環腫瘍細胞の臨床的意義2016

    • Author(s)
      石黒 友唯、崎浜 秀康
    • Organizer
      第75回 日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Related Report
      2015 Research-status Report
  • [Presentation] Preoperative Detection of Circulating Tumor Cells and Disseminated Tumor Cells in Patients with Colorectal Carcinoma2016

    • Author(s)
      石黒 友唯
    • Organizer
      第27回 日本消化器癌発生学会総会
    • Place of Presentation
      城山観光ホテル(鹿児島県・鹿児島市)
    • Year and Date
      2016-09-15
    • Related Report
      2016 Annual Research Report
  • [Presentation] Preoperative detection of circulating tumor cells and disseminated tumor cells in patients with colorectal carcinoma2016

    • Author(s)
      Hideyasu sakihama
    • Organizer
      第71回 日本消化器外科学会総会
    • Place of Presentation
      アスティ徳島(徳島県・徳島市)
    • Year and Date
      2016-07-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 大腸癌における血中遊離癌細胞と骨髄癌細胞2016

    • Author(s)
      崎浜 秀康
    • Organizer
      第71回 日本消化器外科学会総会
    • Place of Presentation
      アスティ徳島(徳島県徳島市)
    • Year and Date
      2016-07-14
    • Related Report
      2015 Research-status Report
  • [Presentation] A pilot study for cellular detection of circulating tumor cells and disseminated tumor cells of patients with hepatocellular carcinoma.2014

    • Author(s)
      Nozomi Minagawa, Hideyasu Sakihama, Nozomi Kobayashi, Mito Obara, Susumu Shibasaki, Kenji Wakayama, Tatsuya Orimo, Tatsuhiko Kakisaka, Yousuke Tsuruga, Shigenori Homma, Hideki Yokoo, Hirofumi Kamachi, Hideki Kawamura, Norihiko Takahashi, Toshiya Kamiyama, Akinobu Taketomi
    • Organizer
      ASCO annual meeting
    • Place of Presentation
      Chicago,IL,USA
    • Year and Date
      2014-05-30 – 2014-06-03
    • Related Report
      2014 Research-status Report
  • [Presentation] 大腸癌における血中遊離癌細胞と骨髄癌細胞~再発予測因子としての比較検討~2013

    • Author(s)
      崎浜 秀康
    • Organizer
      日本外科学会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 大腸癌の骨髄腫瘍細胞はCD133を発現しているか?2013

    • Author(s)
      崎浜 秀康
    • Organizer
      日本消化器外科学会
    • Place of Presentation
      宮崎シーガイヤコンベンションセンター(宮崎市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Preoperative detection of circulating tumor cells and disseminated tumor cells in patients with colorectal carcinoma: which is more predictive for tumor recurrence?2013

    • Author(s)
      Hideyasu Sakihama
    • Organizer
      ASCO annual meeting
    • Place of Presentation
      McCormic Place,(Chicago, USA)
    • Related Report
      2013 Research-status Report
  • [Presentation] Preopepative detection of circulating tumor cells in patients with colorectal carcinoma: correlation with clinicopathological variables and recurrence.2012

    • Author(s)
      Hideyasu Sakihama
    • Organizer
      American society of clinical oncology
    • Place of Presentation
      McCormic Place (Chicago, USA)
    • Related Report
      2012 Research-status Report
  • [Presentation] 大腸癌の骨髄微小転移の同定~病理組織学的因子との関係~2012

    • Author(s)
      崎浜 秀康
    • Organizer
      日本外科学会学術総会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2012 Research-status Report
  • [Presentation] 大腸癌の循環腫瘍細胞と骨髄腫瘍細胞は再発予測マーカーとなりうるか? ~術前血清CEA値との比較~2012

    • Author(s)
      崎浜 秀康
    • Organizer
      日本消化器外科学会総会
    • Place of Presentation
      富山国際会議場(富山)
    • Related Report
      2012 Research-status Report
  • [Presentation] Cellular detection of circulating tumor cells and disseminated tumor cells of patients with hepatocellular carcinoma2012

    • Author(s)
      崎浜 秀康
    • Organizer
      日本癌学会
    • Place of Presentation
      札幌医科大学(札幌)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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