Decion of micrometastases in digestive system cancer and its clinical application

• Project/Area Number: 24591967
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Hokkaido University
• Principal Investigator: Hideyasu Sakihama 北海道大学, 医学研究科, 客員研究員 (50533676)
• Co-Investigator(Kenkyū-buntansha): 尾崎 倫孝 北海道大学, 保健科学研究院, 教授 (80256510) ; 神山 俊哉 北海道大学, 医学研究科, 准教授 (80322816)
• Project Period (FY): 2012-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 循環腫瘍細胞 / 骨髄腫瘍細胞 / 微小転移 / 予後 / 消化器癌 / 治療方針

Outline of Final Research Achievements

The purposes of the study are to detect circulating tumor cells (CTC) and disseminated tumor cells (DTC) in digestive system cancer and to examine how we apply into the clinical settings.
Preoperative positive rates of CTC and DTC in colon cancer patients were 23% and 26%,respectively. There is a significant higher incidence of postoperative recurrence and cancer related death in patients with CTC positive compared with in negative patients.

Research Products

• [Presentation] 大腸癌の循環腫瘍細胞と骨髄腫瘍細胞～特にstage2再発症例からみた臨床応用の可能性について～ (2017)
  • Author(s): 崎浜 秀康
  • Organizer: 第13回 日本消化管学会総会学術集会
  • Place of Presentation: 名古屋国際会議場（愛知県・名古屋市）
  • Year and Date: 2017-02-17
• [Presentation] EMTに着目した胃癌の循環腫瘍細胞の臨床的意義 (2016)
  • Author(s): 石黒 友唯、崎浜 秀康
  • Organizer: 第７５回 日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-10-06
• [Presentation] Preoperative Detection of Circulating Tumor Cells and Disseminated Tumor Cells in Patients with Colorectal Carcinoma (2016)
  • Author(s): 石黒 友唯
  • Organizer: 第27回 日本消化器癌発生学会総会
  • Place of Presentation: 城山観光ホテル（鹿児島県・鹿児島市）
  • Year and Date: 2016-09-15
• [Presentation] Preoperative detection of circulating tumor cells and disseminated tumor cells in patients with colorectal carcinoma (2016)
  • Author(s): Hideyasu sakihama
  • Organizer: 第71回 日本消化器外科学会総会
  • Place of Presentation: アスティ徳島（徳島県・徳島市）
  • Year and Date: 2016-07-14
• [Presentation] 大腸癌における血中遊離癌細胞と骨髄癌細胞 (2016)
  • Author(s): 崎浜 秀康
  • Organizer: 第７１回 日本消化器外科学会総会
  • Place of Presentation: アスティ徳島（徳島県徳島市）
  • Year and Date: 2016-07-14
• [Presentation] A pilot study for cellular detection of circulating tumor cells and disseminated tumor cells of patients with hepatocellular carcinoma. (2014)
  • Author(s): Nozomi Minagawa, Hideyasu Sakihama, Nozomi Kobayashi, Mito Obara, Susumu Shibasaki, Kenji Wakayama, Tatsuya Orimo, Tatsuhiko Kakisaka, Yousuke Tsuruga, Shigenori Homma, Hideki Yokoo, Hirofumi Kamachi, Hideki Kawamura, Norihiko Takahashi, Toshiya Kamiyama, Akinobu Taketomi
  • Organizer: ASCO annual meeting
  • Place of Presentation: Chicago,IL,USA
  • Year and Date: 2014-05-30 – 2014-06-03
• [Presentation] 大腸癌における血中遊離癌細胞と骨髄癌細胞～再発予測因子としての比較検討～ (2013)
  • Author(s): 崎浜 秀康
  • Organizer: 日本外科学会
  • Place of Presentation: 福岡国際会議場（福岡市）
• [Presentation] 大腸癌の骨髄腫瘍細胞はCD133を発現しているか？ (2013)
  • Author(s): 崎浜 秀康
  • Organizer: 日本消化器外科学会
  • Place of Presentation: 宮崎シーガイヤコンベンションセンター（宮崎市）
• [Presentation] Preoperative detection of circulating tumor cells and disseminated tumor cells in patients with colorectal carcinoma: which is more predictive for tumor recurrence? (2013)
  • Author(s): Hideyasu Sakihama
  • Organizer: ASCO annual meeting
  • Place of Presentation: McCormic Place,（Chicago, USA）
• [Presentation] Preopepative detection of circulating tumor cells in patients with colorectal carcinoma: correlation with clinicopathological variables and recurrence. (2012)
  • Author(s): Hideyasu Sakihama
  • Organizer: American society of clinical oncology
  • Place of Presentation: McCormic Place (Chicago, USA)
• [Presentation] 大腸癌の骨髄微小転移の同定～病理組織学的因子との関係～ (2012)
  • Author(s): 崎浜 秀康
  • Organizer: 日本外科学会学術総会
  • Place of Presentation: 幕張メッセ（千葉）
• [Presentation] 大腸癌の循環腫瘍細胞と骨髄腫瘍細胞は再発予測マーカーとなりうるか？ ～術前血清CEA値との比較～ (2012)
  • Author(s): 崎浜 秀康
  • Organizer: 日本消化器外科学会総会
  • Place of Presentation: 富山国際会議場（富山）
• [Presentation] Cellular detection of circulating tumor cells and disseminated tumor cells of patients with hepatocellular carcinoma (2012)
  • Author(s): 崎浜 秀康
  • Organizer: 日本癌学会
  • Place of Presentation: 札幌医科大学（札幌）