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Development of novel herpes virus therapy on colorectal cancer

Research Project

Project/Area Number 24591969
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionThe University of Tokyo

Principal Investigator

SHINOZAKI Masaru  東京大学, 医科学研究所, 准教授 (10312315)

Co-Investigator(Kenkyū-buntansha) YAZAWA Kentaro  東京大学, 医科学研究所, 助教 (60572542)
TSURITA Giichiro  東京大学, 医科学研究所, 講師 (80345206)
HATA Keisuke  東京大学, 医科学研究所, 助教 (60526755)
Co-Investigator(Renkei-kenkyūsha) TODO Tomoki  東京大学, 医科学研究所, 教授 (80272566)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsがん / ウイルス療法 / 固形腫瘍 / 癌ウイルス療法
Outline of Final Research Achievements

G47delta is a modified herpes simplex virus type 1, which selectively proliferate in only tumor cells and destroy the host cell, and seldom affect non-tumor cells. We aimed to evaluate clinical effect of G47delta on colorectal cancer and performed a pre-clinical study. A cytotoxic assay revealed statistically significant cytotoxicity on cell lines compared with the control, according to the concentration of the virus and the term of the treatment. We confirmed that the virus was incorporated in the tumor cell though X-gal staining assay. Replication assay was performed to investigate proliferation of the virus in the cell lines, and we affirmed it. We made subcutaneous tumors of the cell lines. After injection of the virus to the tumors, we found suppression of tumor growth compared with the control.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2013 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (2 results)

  • [Journal Article] 小児の潰瘍性大腸炎に対するインフリキシマブ使用 国内外の臨床ガイドライン比較2013

    • Author(s)
      藤井 徹朗, 大久保 秀則, 高橋 宏和, 中島 淳, 篠崎 大, 佐藤 元
    • Journal Title

      小児科診療

      Volume: 76 Pages: 491-495

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Crohn病に合併した大腸癌の予後因子2012

    • Author(s)
      篠崎 大, 畑 啓介, 釣田 義一郎
    • Organizer
      日本大腸肛門病学会総会
    • Place of Presentation
      福岡市
    • Related Report
      2012 Research-status Report
  • [Presentation] クローン病術後および内視鏡的拡張療法と抗TNF抗体治療2012

    • Author(s)
      篠崎 大, 畑 啓介, 釣田 義一郎
    • Organizer
      日本外科学会総会
    • Place of Presentation
      千葉市
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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