Optimization of chemoradiotherapy for rectal cancer and contribution of epigenetics in exploration of novel biomarker

• Project/Area Number: 24591972
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Mie University
• Principal Investigator: INOUE Yasuhiro 三重大学, 医学部附属病院, 講師 (20324535)
• Co-Investigator(Kenkyū-buntansha): TANAKA Koji 三重大学, 医学部附属病院, 講師 (10345986) ; OKUGAWA Yoshinaga 三重大学, 医学部附属病院, 助教 (30555545) ; KUSUNOKI Masato 三重大学, 医学(系)研究科, 教授 (50192026)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 直腸癌 / 化学放射線療法 / micro RNA / microRNA / 効果予測 / マーカー / 大腸癌

Outline of Final Research Achievements

The objective of this study was to investigate the potential of circulating miRNAs as novel biomarker for pathologic response to preoperative chemoradiotherapy(CRT) in rectal cancer patients. Five candidate serum miRNAs were detected by using miRNA arrays. From the literature, serum miR-21 and 29a were also selected as candidates miRNAs for the CRT response.We examined the correlation between the expressions of candidate serum miRNAs with clinical parameters including pathological response to preoperative CRT for rectal cancer.Serum miRNA-29a was only significantly associated with good pathological effects, but not independent predictive factors.

Research Products

• [Journal Article] Serum miR-21 as a diagnostic and prognostic biomarker in colorectal cancer. (2013)
  • Author(s): Toiyama Y, Takahashi M, Hur K, Nagasaka T, Tanaka K, Inoue Y, Kusunoki M, Boland CR, Goel A.
  • Journal Title: J Natl Cancer Inst. Volume: 105 Issue: 12 Pages: 849-859
  • DOI: 10.1093/jnci/djt101
  • Peer Reviewed
• [Presentation] 当科における直腸癌集学的治療戦略と新たな治療効果予測マーカーの探索 (2015)
  • Author(s): 井上靖浩、今岡裕基、浦谷 亮、沖 哲、廣 純一郎、三枝 晋、問山裕二、小林美奈子、荒木俊光、田中光司、毛利靖彦、楠 正人
  • Organizer: 第115回日本外科学会定期学術集会
  • Place of Presentation: 名古屋 国際会議場
  • Year and Date: 2015-04-16
• [Presentation] 大腸癌診断及び予後マ－カ－としての血清microRNA-21 (2013)
  • Author(s): 問山裕二、井上靖浩、川本 文、奥川 喜永、三枝 晋、廣 純一郎、田中光司、内田恵一、毛利靖彦、楠 正人
  • Organizer: 第79回大腸癌研究会
  • Place of Presentation: 大阪
• [Presentation] 局所進行直腸癌に対する術前化学放射線療法の課題 (2012)
  • Author(s): 井上靖浩、奥川喜永、廣 純一郎、三枝 晋、問山裕二、小林美奈子、荒木俊光、田中光司、毛利靖彦、楠 正人
  • Organizer: 第67回日本消化器外科学会総会
  • Place of Presentation: 富山
• [Presentation] 大腸癌バイオマーカーとしての血清micro-21の多面的検討
  • Author(s): 問山裕二、高橋雅信、Keun Hur、田中光司、井上靖浩、永坂岳司、楠正人
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: 福岡
• [Presentation] 直腸癌術前化学放射線療法におけるShort CourseとLong Courseの適応と課題
  • Author(s): 井上靖浩、川村幹雄、川本 文、奥川喜永、廣 純一郎、問山裕二、小林美奈子、荒木俊光、田中光司、毛利靖彦、楠 正人
  • Organizer: 第68回日本大腸肛門病学会学術集会
  • Place of Presentation: 東京