Optimization of chemoradiotherapy for rectal cancer and contribution of epigenetics in exploration of novel biomarker
| Project/Area Number |
24591972
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Mie University |
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Principal Investigator |
INOUE Yasuhiro 三重大学, 医学部附属病院, 講師 (20324535)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Koji 三重大学, 医学部附属病院, 講師 (10345986)
OKUGAWA Yoshinaga 三重大学, 医学部附属病院, 助教 (30555545)
KUSUNOKI Masato 三重大学, 医学(系)研究科, 教授 (50192026)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 直腸癌 / 化学放射線療法 / micro RNA / microRNA / 効果予測 / マーカー / 大腸癌 |
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| Outline of Final Research Achievements |
The objective of this study was to investigate the potential of circulating miRNAs as novel biomarker for pathologic response to preoperative chemoradiotherapy(CRT) in rectal cancer patients. Five candidate serum miRNAs were detected by using miRNA arrays. From the literature, serum miR-21 and 29a were also selected as candidates miRNAs for the CRT response.We examined the correlation between the expressions of candidate serum miRNAs with clinical parameters including pathological response to preoperative CRT for rectal cancer.Serum miRNA-29a was only significantly associated with good pathological effects, but not independent predictive factors.
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Report
(4 results)
Research Products
(6 results)
