FDG accumulation related to KRAS oncogene
| Project/Area Number |
24591974
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
HASEGAWA Suguru 京都大学, 医学(系)研究科(研究院), 講師 (10362500)
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| Co-Investigator(Kenkyū-buntansha) |
KAWADA Kenji 京都大学, 大学院医学研究科, 講師 (90322651)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 大腸癌 / FDG-PET検査 / KRAS遺伝子 / 糖代謝 |
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| Outline of Final Research Achievements |
KRAS gene mutations occur in approximately 40 % of colorectal cancers (CRCs) and are associated with resistance to anti-EGFR antibody therapy. We demonstrated FDG accumulation in positron emission tomography (PET) was significantly higher in CRCs with mutated KRAS than in those with wild-type KRAS in a clinical setting. Moreover, using paired isogenic human CRC cell lines that differ only in the mutational status of KRAS gene, we demonstrated that mutated KRAS caused higher FDG accumulation possibly by up-regulation of GLUT1; moreover, HIF-1α additively increased FDG accumulation in hypoxic lesions. FDG-PET might be useful for predicting the KRAS status noninvasively.
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Report
(4 results)
Research Products
(8 results)
