Therapeutic potential of the molecular targeting of PRL-3 and K-ras gene in colorectal cancer.

• Project/Area Number: 24591982
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kitasato University
• Principal Investigator: WATANABE Masahiko 北里大学, 医学部, 教授 (80146604)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: PRL-3 / K-ras / 大腸癌 / 予後 / リンパ節転移 / 遺伝子増幅

Outline of Final Research Achievements

(1) K-ras gene mutation was not correlated with staging factors in primary colorectal cancer, and it was recognized in about 40% of either primary or metastatic tumors.
(2) Clinicopathological analysis was performed for PRL-3 genomic amplification in 100 primary tumors of colorectal cancer, and 44 metastatic liver tumors of colorectal cancer. PRL-3 genomic amplification is more frequently recognized in poorly differentiated colorectal cancer, and cases with PRL-3 genomic amplification showed poorer prognosis than those without it.
(3) PRL-3 genomic amplification was significantly more frequently found in liver tumor of colorectal cancer than in the corresponding primary colorectal cancer.