• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Predictive diagnostics effect and clinical application of circulating cancer stem-like cells in colon cancer patients treated with molecular targeted therapy

Research Project

Project/Area Number 24591984
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionTeikyo University

Principal Investigator

IINUMA HISAE  帝京大学, 医学部, 講師 (30147102)

Co-Investigator(Kenkyū-buntansha) WATANABE Toshiaki  東京大学, 医学部, 教授 (80210920)
YAMADA Hideki  帝京大学, 医学部, 助手 (50525269)
HAYAMA Tamuro  帝京大学, 医学部, 助手 (80533744)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords循環腫瘍細胞 / 癌幹細胞 / 大腸癌 / 転移診断 / 予後予測 / ニッチ / 肝転移 / 骨髄転移 / バイオマーカー / 再発予測 / 治療効果予測
Outline of Final Research Achievements

Recently, we make clear that the some population of CTCs expressing the cancer stem cells marker, and named these cells as circulating tumor stem cell (CTSC). Here we aimed to clarify the clinical significance of CTSC and CTC (CTSC /CTC) in colorectal cancer patients. Multi-marker panel consist of CEA, epithelial markers (CK19, CK20), cancer stem cell marker (CD133, CD44) and new marker X were used for detection of CTSC/CTC.
In this study, we demonstrated that CTSC/CTC level was a significant prognostic factor for OS and DFS in patients with Dukes stage B and C cancer. Next, we assessed the value of CTSC/CTC levels as biomarkers for clinical response in advanced CRC patients treated with molecular target reagent (bevacizumab, cetuximab) and chemotherapy (FOLFOX, FOLFIRI). We demonstrated that CTSC/CTC levels of PB have a predictive value for clinical response and survival in patients treated with these combination therapies.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (76 results)

All 2015 2014 2013 2012 Other

All Journal Article (36 results) (of which Peer Reviewed: 33 results,  Open Access: 6 results,  Acknowledgement Compliant: 1 results) Presentation (40 results) (of which Invited: 2 results)

  • [Journal Article] Clinical significance of microRNA-21 as a biomarker in each Dukes’stage of colorectal cancer.2015

    • Author(s)
      Fukushima Y, Iinuma H, Tsukamoto M, Matsuda K, Hashiguchi Y
    • Journal Title

      Oncol Rep.

      Volume: 33(2) Issue: 2 Pages: 573-582

    • DOI

      10.3892/or.2014.3614

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Synchronous colorectal malignancy and abdominal aortic aneurysm treated with endovascular aneurysm repair followed by laparoscopic colectomy.2015

    • Author(s)
      Kawai K, Sunami E, Tanaka J, Tanaka T, Kiyomatsu T, Nozawa H, Kazama S, Kanazawa T, Hosaka A, Ishihara S, Yamaguchi H, Shigematsu K, Watanabe T.
    • Journal Title

      Int Surg.

      Volume: 100(4) Issue: 4 Pages: 600-603

    • DOI

      10.9738/intsurg-d-14-00111.1

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of revisions of the JSCCR guidelines on the treatment of T1 colorectal carcinomas in Japan.2015

    • Author(s)
      Urabe Y, Tanaka S, Saito Y, Igarashi M, Watanabe T, Sugihara K.
    • Journal Title

      Z Gastroenterol.

      Volume: 53(4) Pages: 291-301

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Local recurrence after endoscopic resection for large colorectal neoplasia: a multicenter prospective study in Japan.2015

    • Author(s)
      Oka S, Tanaka S, Saito Y, Iishi H, Kudo SE, Ikematsu H, Igarashi M, Saitoh Y, Inoue Y, Kobayashi K, Hisabe T, Tsuruta O, Sano Y, Yamano H, Shimizu S, Yahagi N, Watanabe T,Sugihara K
    • Journal Title

      Am J Gastroenterol.

      Volume: 110(5) Issue: 5 Pages: 697-707

    • DOI

      10.1038/ajg.2015.96

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Japanese Society for Cancer of the Colon and Rectum (JSCCR) Guidelines 2014 for treatment of colorectal cancer.2015

    • Author(s)
      Watanabe T, Itabashi M, Shimada Y, Sugihara K
    • Journal Title

      Int J Clin Oncol.

      Volume: 20(2) Issue: 2 Pages: 207-239

    • DOI

      10.1007/s10147-015-0801-z

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between smoking and multiple colorectal cancers in patients with Japanese Lynch syndrome: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum.2015

    • Author(s)
      Tanakaya K, Furukawa Y, Nakamura Y, Hirata K, Tomita N, Tamura K, Sugano K, Ishioka C, Yoshida T, Ishida H, Watanabe T, Sugihara K.
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 45(3) Issue: 3 Pages: 307-310

    • DOI

      10.1093/jjco/hyu218

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of clinical features between suspected familial colorectal cancer type X and Lynch syndrome in Japanese patients with colorectal cancer:2015

    • Author(s)
      Yamaguchi T, Furukawa Y, Nakamura Y, Matsubara N, Ishikawa H, Arai M, Tomita N, Tamura K, Sugano K, Ishioka C, Yoshida T, Moriya Y, Ishida H, Watanabe T, Sugihara K;
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 45(2) Issue: 2 Pages: 153-159

    • DOI

      10.1093/jjco/hyu190

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Patient factors predisposing to complications following laparoscopic surgery for colorectal cancers.2015

    • Author(s)
      Ishihara S, Matsuda K, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Nozawa H, Kazama S, Kanazawa T, Yamaguchi H, Sunami E, Kitayama J, Hashiguchi Y, Watanabe T.
    • Journal Title

      Surg Laparosc Endosc Percutan Tech.

      Volume: 25(2) Issue: 2 Pages: 168-172

    • DOI

      10.1097/sle.0000000000000110

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of carcinoembryonic antigen mRNA in peritoneal lavage by the transcription-reverse transcription concerted method indicates poor prognosis in patients with stage II and III colon cancer.2015

    • Author(s)
      Murono K, Kazama S, Yamaguchi H, Kawai K, Ishihara S, Sunami E, Kitayama J, Satoh Y, Kurihara M, Yatomi Y, Watanabe T.
    • Journal Title

      Surgery

      Volume: 157 Issue: 2 Pages: 322-30

    • DOI

      10.1016/j.surg.2014.09.015

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase I clinical study of multiple epitope peptide vaccine combined with chemoradiation therapy in esophageal cancer patients2014

    • Author(s)
      Iinuma H, Fukushima R, Inaba T,他全15名
    • Journal Title

      J. Transl. Med

      Volume: 12(1) Issue: 1 Pages: 84-84

    • DOI

      10.1186/1479-5876-12-84

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Allelic Imbalance at an 8q24 Oncogenic SNP is Involved in Activating MYC in Human Colorectal Cancer2014

    • Author(s)
      Sugimachi K, Niida A, Yamamoto K, Shimamura T, Imoto S, Iinuma H, Shinden Y, Eguchi H, Sudo T, Watanabe M, Tanaka J, Kudo S, Hase K, Kusunoki M, Yamada K, Shimada Y, Sugihara K, Maehara Y, Miyano S, Mori M, Mimori K
    • Journal Title

      Ann Surg Oncol

      Volume: 21 Issue: S4 Pages: 3468-3476

    • DOI

      10.1245/s10434-013-3468-6

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Proximal shift of colorectal cancer along with aging.2014

    • Author(s)
      Iida Y, Kawai K, Tsuno NH, Ishihara S, Yamaguchi H, Sunami E, Kitayama J, Watanabe T.
    • Journal Title

      Clin Colorectal Cancer

      Volume: 13 Issue: 4 Pages: 213-8

    • DOI

      10.1016/j.clcc.2014.06.005

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic impact of tumor location in stage IV colon cancer: a propensity score analysis in a multicenter study.2014

    • Author(s)
      Ishihara S, Nishikawa T2, Tanaka T2, Tanaka J2, Kiyomatsu T2, Kawai K2, Hata K2, Nozawa H2, Kanazawa T2, Kazama S2, Yamaguchi H2, Sunami E2, Kitayama J2, Hashiguchi Y3, Sugihara K4, Watanabe T5.
    • Journal Title

      Int J Surg.

      Volume: 12(9) Issue: 9 Pages: 925-30

    • DOI

      10.1016/j.ijsu.2014.07.270

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] S-1 as adjuvant chemotherapy for stage III colon cancer: a randomized phase III study (ACTS-CC trial).2014

    • Author(s)
      Yoshida M, Ishiguro M, Ikejiri K, Mochizuki I, Nakamoto Y, Kinugasa Y, Takagane A, Endo T, Shinozaki H, Takii Y, Mochizuki H, Kotake K, Kameoka S, Takahashi K, Watanabe T, Watanabe M, Boku N, Tomita N, Nakatani E, Sugihara K
    • Journal Title

      Ann Oncol.

      Volume: 25(9) Issue: 9 Pages: 1743-1749

    • DOI

      10.1093/annonc/mdu232

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of extraperitoneal stoma-associated internal hernia after abdominoperineal resection.2014

    • Author(s)
      Yokoyama Y, Kawai K, Kazama S, Yoneyama S, Tanaka J, Tanaka T, Kiyomatsu T, Nozawa H, Kanazawa T, Yamaguchi H, Ishihara S, Sunami E, Kitayama J, Watanabe T.
    • Journal Title

      World J Surg Oncol.

      Volume: 12 Issue: 1 Pages: 141-141

    • DOI

      10.1186/1477-7819-12-141

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urethral metastasis from a sigmoid colon carcinoma: a quite rare case report and review of the literature.2014

    • Author(s)
      Kazama S, Kitayama J, Sunami E, Niimi A, Nomiya A, Homma Y, Watanabe T.
    • Journal Title

      BMC Surg.

      Volume: 14 Issue: 1 Pages: 31-31

    • DOI

      10.1186/1471-2482-14-31

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Barium enema and CT volumetry for predicting pathologic response to preoperative chemoradiotherapy in rectal cancer patients.2014

    • Author(s)
      Murono K, Kawai K, Tsuno NH, Ishihara S, Yamaguchi H, Sunami E, Kitayama J, Watanabe T.
    • Journal Title

      Dis Colon Rectum.

      Volume: 57(6) Issue: 6 Pages: 715-24

    • DOI

      10.1097/dcr.0000000000000070

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in colorectal cancer care in japan before and after guideline publication: a nationwide survey about D3 lymph node dissection and adjuvant chemotherapy.2014

    • Author(s)
      Ishiguro M, Higashi T, Watanabe T, Sugihara K
    • Journal Title

      J Am Coll Surg.

      Volume: 218(5) Issue: 5 Pages: 969-977

    • DOI

      10.1016/j.jamcollsurg.2013.12.046

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prediction of response to preoperative chemoradiotherapy in rectal cancer by using reverse transcriptase polymerase chain reaction analysis of four genes2014

    • Author(s)
      Watanabe T, Kobunai T, Akiyoshi T, Matsuda K, Ishihara S, Nozawa K.
    • Journal Title

      Dis Colon Rectum.

      Volume: 57 Issue: 1 Pages: 23

    • DOI

      10.1097/01.dcr.0000437688.33795.9d

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical benefit of surgery for stage IV colorectal cancer with synchronous peritoneal metastasis2014

    • Author(s)
      Kobayashi H, Kotake K, Funahashi K, Hase K, Hirata K, Iiai T, Kameoka S, Kanemitsu Y, Maeda K, Murata A, Ohue M, Shirouzu K, Takahashi K, Watanabe T, Yano H, Yatsuoka T, Hashiguchi Y, Sugihara K
    • Journal Title

      J Gastroenterol.

      Volume: 49 Issue: 4 Pages: 646

    • DOI

      10.1007/s00535-013-0820-3

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diagnosis and management of hereditary colorectal cancer according to the JSCCR Guidelines 2012 for the Clinical Practice of Hereditary Colorectal Cance2014

    • Author(s)
      Ishida H, Iwama T, Tomita N, Koizumi K, Akagi K, Ishiguro M, Watanabe T, Sugihara K.
    • Journal Title

      Nihon Rinsho

      Volume: 72(1) Pages: 143-149

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant Expression of Plastin-3 Via Copy Number Gain Induces the Epithelial-Mesenchymal Transition in Circulating Colorectal Cancer Cells2013

    • Author(s)
      Sugimachi K, Yokobori T, Iinuma H, Ueda M, Ueo H, Shinden Y, Eguchi H, Sudo T, Suzuki A, Maehara Y, Mori M, Mimori K
    • Journal Title

      Ann Surg Oncol

      Volume: 20 Issue: 11 Pages: 3366-3377

    • DOI

      10.1245/s10434-013-3366-y

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Contrasting expression patterns of histone mRNA and microRNA 760 in patients with gastric cancer2013

    • Author(s)
      Iwaya T, Fukagawa T, Suzuki Y, Takahashi Y, Sawada G, Ishibashi M, Kurashige J, Sudo T, Tanaka F, Shibata K, Endo F, Katagiri H, Ishida K, Kume K, Nishizuka S, Iinuma H, Wakabayashi G, Mori M, Sasako M, Mimori K.
    • Journal Title

      Clin Cancer Res

      Volume: 19 Issue: 23 Pages: 6438

    • DOI

      10.1158/1078-0432.ccr-12-3186

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis2013

    • Author(s)
      Yokobori T, Iinuma H, Shimamura T, Imoto S, Sugimachi K, Ishii H, Iwatsuki M, Ota D, Ohkuma M, Iwaya T, Nishida N, Kogo R, Sudo T, Tanaka F, Shibata K, Toh H, Sato T, Barnard GF, Fukagawa T, Yamamoto S, Nakanishi H, Sasaki S, Miyano S, Watanabe T, Kuwano H, Mimori K, Pantel K, Mori M.
    • Journal Title

      Cancer Res

      Volume: 73 Issue: 7 Pages: 2059

    • DOI

      10.1158/0008-5472.can-12-0326

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The rs6983267 SNP Is Associated with MYC Transcription Efficiency, Which Promotes Progression and Worsens Prognosis of Colorectal Cancer.2013

    • Author(s)
      Takatsuno Y
    • Journal Title

      Ann Surg Oncol

      Volume: 20 Issue: 4 Pages: 1395-402

    • DOI

      10.1245/s10434-012-2657-z

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Plastin3 Is a Novel Marker for Circulating Tumor Cells Undergoing the Epithelial-Mesenchymal Transition and Is Associated with Colorectal Cancer Prognosis.2013

    • Author(s)
      Yokobori T, Iinuma H, Shimamura T et al.
    • Journal Title

      Cancer Res

      Volume: 73(7) Pages: 2059-2069

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Accurate and rapid novel genetic diagnosis for detection of sentinel lymph node metastasis in breast cancer patients.2012

    • Author(s)
      Iinuma H, Tamura J, Omoto D et al.
    • Journal Title

      Br J Cancer

      Volume: 107(4) Issue: 4 Pages: 724-731

    • DOI

      10.1038/bjc.2012.300

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Multicenter, phase II clinical trial of cancer vaccination for advanced esophageal cancer with three peptides derived from novel cancer-testis antigens.2012

    • Author(s)
      Kono K
    • Journal Title

      J Transl Med

      Volume: 10(141) Issue: 1 Pages: 141-141

    • DOI

      10.1186/1479-5876-10-141

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Increased Risk for CRC in Diabetic Patients with the Nonrisk Allele of SNPs at 8q242012

    • Author(s)
      Ishimaru S, Iinuma H, et al
    • Journal Title

      Ann Surg Oncol

      Volume: 21(in press) Issue: 9 Pages: 21-21

    • DOI

      10.1245/s10434-012-2278-6

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chromosomal instability (CIN) phenotype, CIN high or CIN low, predicts survival for colorectal cancer2012

    • Author(s)
      Watanabe T, Iinuma H, et al
    • Journal Title

      J Clin Oncol

      Volume: 30 Issue: 18 Pages: 2256

    • DOI

      10.1200/jco.2011.38.6490

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological and prognostic significance of microRNA-107 and its relationship to DICER1 mRNA expression in gastric cancer2012

    • Author(s)
      Inoue T, Iinuma H, et al
    • Journal Title

      Oncol Rep

      Volume: 27 Pages: 1759-64

    • DOI

      10.3892/or.2012.1709

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of CTCs and CSCs of tumor drainge vein blood in Dukes' stage B and C colorectal cancer2012

    • Author(s)
      Shimada R, Iinuma H, et al
    • Journal Title

      Oncol Rep

      Volume: 27 Issue: 4 Pages: 947-53

    • DOI

      10.3892/or.2012.1649

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic significance of PDCD4 expression and association with microRNA-21 in each Dukes' stage of colorectal cancer patients2012

    • Author(s)
      Horiuchi A, Iinuma H, et al
    • Journal Title

      Oncol Rep

      Volume: 27 Pages: 1384-92

    • DOI

      10.3892/or.2012.1648

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 2cm以下の大腸進行癌の特徴2012

    • Author(s)
      飯沼久恵、石原聡一郎、渡邉聡明
    • Journal Title

      INTESTINE

      Volume: 16 (4) Pages: 331-336

    • Related Report
      2012 Research-status Report
  • [Journal Article] 微量癌細胞研究の展開2012

    • Author(s)
      飯沼久恵、渡邉聡明
    • Journal Title

      日本外科学会誌

      Volume: 113(2) Pages: 177-184

    • NAID

      110009425990

    • Related Report
      2012 Research-status Report
  • [Journal Article] 大腸癌Dukes' Stage BおよびC症例における腫瘍還流血中遊離癌細胞のバイオマーカーとしての有用性2012

    • Author(s)
      島田竜, 飯沼久恵, 田村純子
    • Journal Title

      癌と化学療法

      Volume: 39(12) Pages: 1763-1765

    • Related Report
      2012 Research-status Report
  • [Presentation] 大腸癌ステージ別におけるmicroRNA-21の予後予測バイオマーカーとしての有用性2014

    • Author(s)
      福島慶久、飯沼久恵、田村純子、塚本充雄、赤羽根拓弥、島田竜、中村圭介、土屋剛史、藤井正一、野澤慶次郎、松田圭二、橋口陽二郎
    • Organizer
      第27回日本バイオセラピィ学会集会総会
    • Place of Presentation
      大阪
    • Year and Date
      2014-12-04 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 大腸癌血漿エクソソーム由来microRNA-21検出の臨床的意義と予後予測診断の有用性の検討2014

    • Author(s)
      田村純子、飯沼久恵、塚本充雄、福島慶久、赤羽根拓弥、中村圭介、島田竜、土屋剛史、野澤慶次郎、藤井正一、松田圭二、橋口陽二郎
    • Organizer
      第27回日本バイオセラピィ学会集会総会
    • Place of Presentation
      大阪
    • Year and Date
      2014-12-04 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 大腸癌組織におけるDicer1mRNAおよびDrosha mRNA発現の臨床的意義2014

    • Author(s)
      赤羽根拓弥、飯沼久恵、田村純子、塚本充雄、島田竜、中村圭介、藤井正一、野澤慶次郎、松田圭二、橋口陽二郎
    • Organizer
      第27回日本バイオセラピィ学会集会総会
    • Place of Presentation
      大阪
    • Year and Date
      2014-12-04 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 食道癌ペプチドワクチン療法におけるCTCの分子生物学的特徴とバイオマーカーとしての有用性2014

    • Author(s)
      飯沼久恵、田村純子、小川越史、堀川昌宏、矢口義久、稲葉毅、河野浩二、池田正、中村祐輔、福島亮治
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 循環血液中のエクソソーム内マイクロRNAは消化器癌の有用なバイオマーカーとなる2014

    • Author(s)
      杉町圭史、松村多恵、新田吉陽、井口友宏、江口英利。飯沼久恵、落合孝広、調 憲、前原喜彦、三森功士
    • Organizer
      73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 下部直腸癌の治療戦略―術前治療の意義とその効果予測2014

    • Author(s)
      橋口陽二郎、神藤英二、飯沼久恵、上野秀樹、長谷和生、藤井正一、野澤慶次郎、松田圭二
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 大腸癌患者における血漿エクソソーム由来microRNA-21のバイオマーカーとしての臨床的意義2014

    • Author(s)
      田村純子、飯沼久恵、福島慶久、赤羽根拓弥、中村圭介、土屋剛史、端山軍、藤井正一、野澤慶次郎、松田圭二、橋口陽二郎
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Phase I study of peptide vaccine following chemoradiation therapy against unresectable esophageal cancers patients.2014

    • Author(s)
      Iinuma H, Tamura J, Inoue T, Ogawa E, Horikawa M, Ikeda Y, Inaba T, Okinaga K, Yoshida K, Tsunoda T, Nakamura Y, Fukushima R
    • Organizer
      The52nd Annual Meeting of Japan Society of Clinical Oncology
    • Place of Presentation
      Yokohama
    • Year and Date
      2014-08-28 – 2014-08-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] 食道癌ペプチドワクチン療法におけるCTCのバイオマーカーとしての有用性2014

    • Author(s)
      飯沼久恵、田村純子、小川越史、井上泰介、堀川昌宏、矢口義久、池田佳史、稲葉毅、中村祐輔、福島亮治
    • Organizer
      第35回癌免疫外科研究会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 胃癌症例におけるDicer1発現と臨床病理学的因子および予後との関連性2014

    • Author(s)
      井上泰介、飯沼久恵、田村純子、小川越史、堀川昌宏、矢口義久、池田佳史、稲葉毅、福島亮治
    • Organizer
      第35回癌免疫外科研究会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 大腸癌血漿エクソソームにおけるmicroRNA-21の発現と臨床的意義2014

    • Author(s)
      田村純子、飯沼久恵、福島慶久、赤羽根拓弥、中村圭介、土屋剛史、端山軍、藤井正一、野澤慶次郎、松田圭二、橋口陽二郎
    • Organizer
      第35回癌免疫外科研究会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 大腸癌組織におけるmicroRNA-21の発現と臨床的意義2014

    • Author(s)
      福島慶久、飯沼久恵、田村純子、赤羽根拓弥、中村圭介、土屋剛史、端山軍、藤井正一、野澤慶次郎、松田圭二、橋口陽二郎
    • Organizer
      第35回癌免疫外科研究会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 大腸癌における遊離癌幹様細 を指標とした腹膜再発遺伝子診断の有用性2014

    • Author(s)
      飯沼久恵、田村純子、福島慶久、赤羽根拓弥、堀内敦、中村圭介、土屋剛史、山田英樹、端山軍、野澤慶次郎、藤井正一、松田圭二、橋口陽二郎
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 大腸癌ステージ別によるmicroRNA-21の予後予測バイオマーカーとしての有用性2014

    • Author(s)
      福島慶久、飯沼久恵、田村純子、赤羽根拓弥、堀内敦、中村圭介、山田英樹、端山軍、土屋剛史、藤井正一、野沢慶次郎、松田圭二、橋口陽二郎
    • Organizer
      第114回日本外科学会定期学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-04-03 – 2014-04-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] 胃癌の末梢血および脾臓細胞におけるMDSC細胞の免疫抑制機構2014

    • Author(s)
      飯沼久恵、田村純子、福島亮治、冲永功太
    • Organizer
      第27回日本小児脾臓研究会
    • Place of Presentation
      熊本
    • Year and Date
      2014-04-01
    • Related Report
      2014 Annual Research Report 2013 Research-status Report
  • [Presentation] 大腸癌における血中循環癌細胞の検出と臨床的意義2013

    • Author(s)
      飯沼久恵、田村純子、福島慶久、赤羽根拓弥、島田竜、堀内敦、中村圭介、山田英樹、端山軍、野澤慶次郎、石原聡一郎、松田圭二、三森功士、渡邉聡明、森正樹、橋口陽二郎
    • Organizer
      第113回日本外科学会総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 大腸癌におけるDICER1mRNAの発現と臨床病理学的因子および予後との関連性2013

    • Author(s)
      赤羽根拓弥、飯沼久恵、福島慶久、堀内敦、中村圭介、山田英樹、端山軍、野澤慶次郎、石原聡一郎、松田圭二、渡邉聡明、橋口陽二郎
    • Organizer
      第113回日本外科学会総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] 大腸癌における新規癌抑制遺伝子PDCD4 mRNA発現の意義とmicroRNA-21との関連性2013

    • Author(s)
      福島慶久、飯沼久恵、堀内敦、赤羽根拓弥、中村圭介、島田竜、山田英樹、端山軍、野澤慶次郎、石原聡一郎、松田圭二、渡邉聡明、橋口陽二郎
    • Organizer
      第113回日本外科学会総会
    • Place of Presentation
      福岡
    • Related Report
      2013 Research-status Report
  • [Presentation] 大腸癌におけるmicroRNA-21、microRNA-155の臨床的意義とPDCDmRNA、TP53INP1mRNAとの関連性2012

    • Author(s)
      飯沼久恵、田村純子、渋谷肇、他
    • Organizer
      第112回日本外科学会総会
    • Place of Presentation
      千葉市
    • Related Report
      2012 Research-status Report
  • [Presentation] 胃癌におけるmicroRNA-107の臨床的意義およびDICER1mRNAとの関連性2012

    • Author(s)
      井上泰介、飯沼久恵、田村純子、他
    • Organizer
      第112回日本外科学会総会
    • Place of Presentation
      千葉市
    • Related Report
      2012 Research-status Report
  • [Presentation] 大腸癌Dukes stage BおよびC症例における腫瘍環流血中遊離癌細胞のバイオマーカーとしての有用性2012

    • Author(s)
      島田竜、飯沼久恵、田村純子、他
    • Organizer
      第33回癌免疫外科研究会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Research-status Report
  • [Presentation] TRCR法による早期乳癌患者における高精度センチネルリンパ節転移診断2012

    • Author(s)
      田村純子、飯沼久恵、尾本大輔、他
    • Organizer
      第33回癌免疫外科研究会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Research-status Report
  • [Presentation] 胃癌原発部組織におけるmicroRNA-107発現とその臨床的意義2012

    • Author(s)
      井上泰介、飯沼久恵、田村純子、他
    • Organizer
      第33回癌免疫外科研究会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Research-status Report
  • [Presentation] 大腸癌Dukes stage別による、新規癌抑制遺伝子PDCD4の発現と再発および予後との関連性2012

    • Author(s)
      堀内敦、飯沼久恵、田村純子
    • Organizer
      第33回癌免疫外科研究会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Research-status Report
  • [Presentation] Clinical significance of circulating tumor cells detection in cancer patients.2012

    • Author(s)
      Hisae Iinuma.
    • Organizer
      5th World CTC Summit
    • Place of Presentation
      Singapole
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Prognostic significance of PDCD4 mRNA and association with microRNA-21 in each Dukes stage of colorectal cancer patients.2012

    • Author(s)
      Hisae Iinuma, Atsushi Horiuchi, Junko Tamura, et al.
    • Organizer
      71th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      Sapporo
    • Related Report
      2012 Research-status Report
  • [Presentation] 消化器癌におけるCnacer stem like cellを指標とした微量癌細胞検出の臨床的意義2012

    • Author(s)
      飯沼久恵、田村純子、島田竜、他
    • Organizer
      第50回日本癌治療学会学術集会(JSCO賞受賞)
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] ヒト食道癌cancer stem-like cellに対する細胞障害性T細胞クローンの認識効果2012

    • Author(s)
      飯沼久恵、田村純子、小川越史、他
    • Organizer
      第25回日本バイオセラピイ学会学術集会総会(ワークショップ)
    • Place of Presentation
      倉敷
    • Related Report
      2012 Research-status Report
  • [Presentation] 乳癌センチネルリンパ節の定量的遺伝子診断の有用性2012

    • Author(s)
      田村純子、飯沼久恵、尾本大輔、他
    • Organizer
      第25回日本バイオセラピイ学会学術集会総会
    • Place of Presentation
      倉敷
    • Related Report
      2012 Research-status Report
  • [Presentation] 大腸癌におけるDicer1の発現と再発および予後との関連性2012

    • Author(s)
      赤羽根拓弥、飯沼久恵、田村純子、他
    • Organizer
      第25回日本バイオセラピイ学会学術集会総会
    • Place of Presentation
      倉敷
    • Related Report
      2012 Research-status Report
  • [Presentation] 大腸癌組織におけるmicrRNA-21の発現と予後との関連性2012

    • Author(s)
      福島慶久、飯沼久恵、田村純子、他
    • Organizer
      第25回日本バイオセラピイ学会学術集会総会
    • Place of Presentation
      倉敷
    • Related Report
      2012 Research-status Report
  • [Presentation] 大腸癌におけるDICER1mRNA発現の予後予測因子としての有用性

    • Author(s)
      赤羽根拓弥、飯沼久恵、田村純子、福島慶久、堀内敦、中村圭介、山田英樹、端山軍、野澤慶次郎、石原聡一郎、松田圭二、橋口陽二郎
    • Organizer
      第34回癌免疫外科研究会
    • Place of Presentation
      岡山
    • Related Report
      2013 Research-status Report
  • [Presentation] 胃癌症例におけるmicroRNA-107発現の臨床的意義

    • Author(s)
      田村純子、飯沼久恵、井上泰介、堀川昌宏、小川越史、小出泰平、池田佳史、稲葉毅、福島亮治
    • Organizer
      第34回癌免疫外科研究会
    • Place of Presentation
      岡山
    • Related Report
      2013 Research-status Report
  • [Presentation] 大腸癌予後予測マーカーとしての血中循環癌細胞の新たな展開

    • Author(s)
      飯沼久恵、三森功士、横堀武彦、田村純子、野澤慶次郎、石原聡一郎、松田圭二、渡邉聡明、橋口陽二郎、森正樹
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 切除不能食道癌に対する放射線化学療法併用ペプチドワクチン療法の第I相臨床試験

    • Author(s)
      田村純子、飯沼久恵、井上泰介、小川越史、堀川昌宏、池田佳史、稲葉毅、吉田浩二、角田卓也、中村祐輔、冲永功太、福島亮治
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] 大腸癌におけるDICER1mRNA発現の予後予測因子としての有用性

    • Author(s)
      飯沼久恵、赤羽根拓弥、田村純子、福島慶久、堀内敦、中村圭介、山田英樹、端山軍、野澤慶次郎、藤井正一、松田圭二、橋口陽二郎
    • Organizer
      第51回日本癌治療学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] ヒト食道癌の癌幹細胞に対するmultiple CTLクローンによる治療効果増強

    • Author(s)
      飯沼久恵、田村純子、井上泰介、小川越史、堀川昌宏、池田佳史、稲葉毅、冲永功太、福島亮治
    • Organizer
      第26回日本バイオセラピイ学会学術集会総会
    • Place of Presentation
      盛岡
    • Related Report
      2013 Research-status Report
  • [Presentation] 大腸癌組織における新規癌抑制遺伝子PDCD4mRNA発現の臨調帝意義とmicrRNA-21との関連性

    • Author(s)
      福島慶久、飯沼久恵、田村純子、赤羽根拓弥、堀内敦、中村圭介、土屋剛史、山田英樹、端山軍、野澤慶次郎、藤井正一、松田圭二、橋口陽二郎
    • Organizer
      第26回日本バイオセラピイ学会学術集会総会
    • Place of Presentation
      盛岡
    • Related Report
      2013 Research-status Report
  • [Presentation] 細胞診陰性胃癌症例における腹腔遊離癌幹様細胞遺伝子検出による腹膜再発予測診断の有用性

    • Author(s)
      田村純子、飯沼久恵、小川越史、井上泰介、矢口義久、堀川昌宏、池田佳史、稲葉毅、福島亮治
    • Organizer
      第26回日本バイオセラピイ学会学術集会総会
    • Place of Presentation
      盛岡
    • Related Report
      2013 Research-status Report
  • [Presentation] 大腸癌治癒切除における腹腔洗浄液中遊離癌幹様細部を指標とした腹膜再発予測の遺伝子診断

    • Author(s)
      端山軍、飯沼久恵、田村純子、福島慶久、赤羽根拓弥、堀内敦、中村圭介、土屋剛史、山田英樹、野澤慶次郎、藤井正一、松田圭二、橋口陽二郎
    • Organizer
      第26回日本バイオセラピイ学会学術集会総会
    • Place of Presentation
      盛岡
    • Related Report
      2013 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi