Predictive diagnostics effect and clinical application of circulating cancer stem-like cells in colon cancer patients treated with molecular targeted therapy
| Project/Area Number |
24591984
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Teikyo University |
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Principal Investigator |
IINUMA HISAE 帝京大学, 医学部, 講師 (30147102)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Toshiaki 東京大学, 医学部, 教授 (80210920)
YAMADA Hideki 帝京大学, 医学部, 助手 (50525269)
HAYAMA Tamuro 帝京大学, 医学部, 助手 (80533744)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 循環腫瘍細胞 / 癌幹細胞 / 大腸癌 / 転移診断 / 予後予測 / ニッチ / 肝転移 / 骨髄転移 / バイオマーカー / 再発予測 / 治療効果予測 |
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| Outline of Final Research Achievements |
Recently, we make clear that the some population of CTCs expressing the cancer stem cells marker, and named these cells as circulating tumor stem cell (CTSC). Here we aimed to clarify the clinical significance of CTSC and CTC (CTSC /CTC) in colorectal cancer patients. Multi-marker panel consist of CEA, epithelial markers (CK19, CK20), cancer stem cell marker (CD133, CD44) and new marker X were used for detection of CTSC/CTC.
In this study, we demonstrated that CTSC/CTC level was a significant prognostic factor for OS and DFS in patients with Dukes stage B and C cancer. Next, we assessed the value of CTSC/CTC levels as biomarkers for clinical response in advanced CRC patients treated with molecular target reagent (bevacizumab, cetuximab) and chemotherapy (FOLFOX, FOLFIRI). We demonstrated that CTSC/CTC levels of PB have a predictive value for clinical response and survival in patients treated with these combination therapies.
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Report
(4 results)
Research Products
(76 results)
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[Journal Article] Synchronous colorectal malignancy and abdominal aortic aneurysm treated with endovascular aneurysm repair followed by laparoscopic colectomy.2015
Author(s)
Kawai K, Sunami E, Tanaka J, Tanaka T, Kiyomatsu T, Nozawa H, Kazama S, Kanazawa T, Hosaka A, Ishihara S, Yamaguchi H, Shigematsu K, Watanabe T.
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Journal Title
Int Surg.
Volume: 100(4)
Pages: 600-603
DOI
Related Report
Peer Reviewed
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[Journal Article] Local recurrence after endoscopic resection for large colorectal neoplasia: a multicenter prospective study in Japan.2015
Author(s)
Oka S, Tanaka S, Saito Y, Iishi H, Kudo SE, Ikematsu H, Igarashi M, Saitoh Y, Inoue Y, Kobayashi K, Hisabe T, Tsuruta O, Sano Y, Yamano H, Shimizu S, Yahagi N, Watanabe T,Sugihara K
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Journal Title
Am J Gastroenterol.
Volume: 110(5)
Pages: 697-707
DOI
Related Report
Peer Reviewed
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[Journal Article] Relationship between smoking and multiple colorectal cancers in patients with Japanese Lynch syndrome: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum2015
Author(s)
Tanakaya K, Furukawa Y, Nakamura Y, Hirata K, Tomita N, Tamura K, Sugano K, Ishioka C, Yoshida T, Ishida H, Watanabe T, Sugihara K.
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Journal Title
Japanese Journal of Clinical Oncology
Volume: 45(3)
Pages: 307-310
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Comparison of clinical features between suspected familial colorectal cancer type X and Lynch syndrome in Japanese patients with colorectal cancer: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum2015
Author(s)
Yamaguchi T, Furukawa Y, Nakamura Y, Matsubara N, Ishikawa H, Arai M, Tomita N, Tamura K, Sugano K, Ishioka C, Yoshida T, Moriya Y, Ishida H, Watanabe T, Sugihara K;
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Journal Title
Japanese Journal of Clinical Oncology
Volume: 45(2)
Pages: 153-159
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Patient factors predisposing to complications following laparoscopic surgery for colorectal cancers.2015
Author(s)
Ishihara S, Matsuda K, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Nozawa H, Kazama S, Kanazawa T, Yamaguchi H, Sunami E, Kitayama J, Hashiguchi Y, Watanabe T.
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Journal Title
Surg Laparosc Endosc Percutan Tech
Volume: 25(2)
Pages: 168-172
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Detection of carcinoembryonic antigen mRNA in peritoneal lavage by the transcription-reverse transcription concerted method indicates poor prognosis in patients with stage II and III colon cancer.2015
Author(s)
Murono K, Kazama S, Yamaguchi H, Kawai K, Ishihara S, Sunami E, Kitayama J, Satoh Y, Kurihara M, Yatomi Y, Watanabe T.
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Journal Title
Surgery.
Volume: 157
Pages: 322-30
DOI
Related Report
Peer Reviewed
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[Journal Article] Allelic imbalance at an 8q24 oncogenic SNP is involved in activating MYC in human colorectal cancer2014
Author(s)
Sugimachi K, Niida A, Yamamoto K, Shimamura T, Imoto S, Iinuma H, Shinden Y, Eguchi H, Sudo T, Watanabe M, Tanaka J, Kudo S, Hase K, Kusunoki M, Yamada K, Shimada Y, Sugihara K, Maehara Y, Miyano S, Mori M, Mimori K
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Journal Title
Ann Surg Oncol.
Volume: 21
Pages: 3468-3476
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Prognostic impact of tumor location in stage IV colon cancer: a propensity score analysis in a multicenter study.2014
Author(s)
Ishihara S, Nishikawa T2, Tanaka T2, Tanaka J2, Kiyomatsu T2, Kawai K2, Hata K2, Nozawa H2, Kanazawa T2, Kazama S2, Yamaguchi H2, Sunami E2, Kitayama J2, Hashiguchi Y3, Sugihara K4, Watanabe T5.
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Journal Title
Int J Surg.
Volume: 12(9)
Pages: 925-30
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] S-1 as adjuvant chemotherapy for stage III colon cancer: a randomized phase III study (ACTS-CC trial).2014
Author(s)
Yoshida M, Ishiguro M, Ikejiri K, Mochizuki I, Nakamoto Y, Kinugasa Y, Takagane A, Endo T, Shinozaki H, Takii Y, Mochizuki H, Kotake K, Kameoka S, Takahashi K, Watanabe T, Watanabe M, Boku N, Tomita N, Nakatani E, Sugihara K
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Journal Title
Ann Oncol.
Volume: 25(9)
Pages: 1743-1749
DOI
Related Report
Peer Reviewed
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[Journal Article] A case of extraperitoneal stoma-associated internal hernia after abdominoperineal resection.2014
Author(s)
Yokoyama Y, Kawai K, Kazama S, Yoneyama S, Tanaka J, Tanaka T, Kiyomatsu T, Nozawa H, Kanazawa T, Yamaguchi H, Ishihara S, Sunami E, Kitayama J, Watanabe T.
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Journal Title
World J Surg Oncol.
Volume: 12
Pages: 141-141
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical benefit of surgery for stage IV colorectal cancer with synchronous peritoneal metastasis.2014
Author(s)
Kobayashi H, Kotake K, Funahashi K, Hase K, Hirata K, Iiai T, Kameoka S, Kanemitsu Y, Maeda K, Murata A, Ohue M, Shirouzu K, Takahashi K, Watanabe T, Yano H, Yatsuoka T, Hashiguchi Y, Sugihara K
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Journal Title
J Gastroenterology
Volume: 49(4)
Pages: 646-54
DOI
Related Report
Peer Reviewed
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[Journal Article] Contrasting expression patterns of histone mRNA and microRNA 760 in patients with gastric cancer2013
Author(s)
Iwaya T, Fukagawa T, Suzuki Y, Takahashi Y, Sawada G, Ishibashi M, Kurashige J, Sudo T, Tanaka F, Shibata K, Endo F, Katagiri H, Ishida K, Kume K, Nishizuka S, Iinuma H, Wakabayashi G, Mori M, Sasako M, Mimori K.
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Journal Title
Clin Cancer Res.
Volume: 19 (23)
Pages: 6438-49
DOI
Related Report
Peer Reviewed
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[Journal Article] Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis2013
Author(s)
Yokobori T, Iinuma H, Shimamura T, Imoto S, Sugimachi K, Ishii H, Iwatsuki M, Ota D, Ohkuma M, Iwaya T, Nishida N, Kogo R, Sudo T, Tanaka F, Shibata K, Toh H, Sato T, Barnard GF, Fukagawa T, Yamamoto S, Nakanishi H, Sasaki S, Miyano S, Watanabe T, Kuwano H, Mimori K, Pantel K, Mori M.
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Journal Title
Cancer Res.
Volume: 1; 73(7)
Pages: 2059-2069
DOI
Related Report
Peer Reviewed
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[Presentation] Phase I study of peptide vaccine following chemoradiation therapy against unresectable esophageal cancers patients.2014
Author(s)
Iinuma H, Tamura J, Inoue T, Ogawa E, Horikawa M, Ikeda Y, Inaba T, Okinaga K, Yoshida K, Tsunoda T, Nakamura Y, Fukushima R
Organizer
The52nd Annual Meeting of Japan Society of Clinical Oncology
Place of Presentation
Yokohama
Year and Date
2014-08-28 – 2014-08-30
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