| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
There have been two reasons for the difficulty to regenerate circumferential intestine, namely (1) (2). In the present study liver cells were disseminated instead of intestinal mucosal cells on the inner layer of the scaffold as the epithelial cells, and
P(LA/CL) co-polymer mesh was used as the scaffold instead of the amniotic membrane. The P(LA/CL) co-polymer mesh where the hepatic cells had been disseminated and the greater omentum were made into a double layered sheet, then the double layered sheet was wrapped overlapping three times into a shape of a tube in the abdominal cavity. Thus the tube was composed of the P(LA/CL) co-polymer mesh layer and the omentum layer overlapping three times each other. The tube was incubated in the abdominal cavity so that the epithelial cells should grow and the fibroblasts and bold capillaries should infiltrate into the tube should finally form the intestinal wall-like from.
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