Extended indication of conversion hepatectomy for initially unresectable colorectal liver metastasis
| Project/Area Number |
24591990
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hirosaki University |
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Principal Investigator |
HAKAMADA Kenichi 弘前大学, 医学(系)研究科(研究院), 教授 (30271802)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIDO Keinosuke 弘前大学, 医学部附属病院, 講師 (00436023)
KUDO Daisuke 弘前大学, 医学部附属病院, 講師 (00587024)
TOYOKI Yoshikazu 弘前大学, 大学院医学研究科, 准教授 (70301025)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 大腸癌肝転移 / 化学療法後肝切除 / 化学療法後肝障害 / イリノテカン / 脂肪肝炎 / 脂肪肝 / Conversion therapy / colorectal cancer / steatohepatitis / liver damage / irinotecan / ultrasound / noninvasive analysis / liver resection / 大腸癌 / 脂質代謝 / 有機アニオントランスポーター |
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| Outline of Final Research Achievements |
First, we successfully established a new model of chemotherapy-associated liver damage by treating rats with irinotecan, and found that genetic up-regulation of both cholesterol and fatty acid synthesis occurred prior to pathological fatty degeneration.Second, we introduced a new statistical technique of ultrasound called acoustic structure quantification method to the diagnosis of fatty degeneration caused by chemotherapy. Finally, by integrating multi-modalities of diagnostic imaging and liver function tests, we successfully could improve the surgical results of conversion hepatectomy for initially unresectable colorectal liver metastases as high as 60% of 5 year survival after surgery.
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Report
(4 results)
Research Products
(65 results)
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[Journal Article] Fatty acid synthase-positive hepatocytes and subsequent steatosis in rat livers by irinotecan2015
Author(s)
Sawano T, Shimizu T, Yamada T, Nanashima N, Miura T, Morohashi S, Kudo D, Hui F-M, Kijima H, Hakamada K, Tsuchida S
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Journal Title
Oncology Reports
Volume: 33
Pages: 2151-2160
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] NON-INVASIVE QUANTIFICATION OF LIVER DAMAGE BY A NOVEL APPLICATION FOR STATISTICAL ANALYSIS OF ULTRASOUND SIGNALS2014
Author(s)
Yakoshi Y, Kudo D, Toyoki Y, Isido K, Kimura No, Wakiya T, Sakuraba S, Yoshizawa T, Sakamoto Y, Kijima H, Hakamada K
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Journal Title
Hirosaki Medical Journal
Volume: 65
Pages: 199-208
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Invasive micropapillary carcinoma of the extrahepatic bile duct and its malignant potential.2014
Author(s)
Yoshizawa T, Toyoki Y, Hirai H, Haga T, Toba T, Sakuraba S, Okano K, Wu Y, Seino H, Morohashi S, Hakamada K, Kijima H.
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Journal Title
Oncology Reports
Volume: 32
Issue: 4
Pages: 1355-61
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] FGF3/FGF4 amplification and multiple lung metastases in responders to sorafenib in hepatocellular carcinoma.2013
Author(s)
Arao T, Ueshima K, Matsumoto K, Nagai T, Kimura H, Hagiwara S, Sakurai T, Haji S, Kanazawa A, Hidaka H, Iso Y, Kubota K, Shimada M, Utsunomiya T, Hirooka M, Hiasa Y, Toyoki Y, Hakamada K, Yasui K, Kumada T, Toyoda H, Sato S, Hisai H, Kuzuya T, Tsuchiya K, Izumi N, Arii S, Nishio K, Kudo M.
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Journal Title
Hepatology
Volume: 57
Issue: 4
Pages: 1407-1415
DOI
Related Report
Peer Reviewed
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[Presentation] 進行直腸癌に対する術前化学療法の有効性2014
Author(s)
坂本 義之, 村田 暁彦, 小山 基, 諸橋 一, 長谷部 達也, 齋藤 傑, 袴田 健一
Organizer
第69回日本消化器外科学会総会
Place of Presentation
郡山市
Year and Date
2014-07-16 – 2014-07-18
Related Report
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[Presentation] 同時性他臓器転移を伴う大腸癌の治療戦略2014
Author(s)
諸橋 一, 齋藤 傑, 長谷部 達也, 坂本 義之, 小山 基, 村田 暁彦, 袴田 健一
Organizer
第69回日本消化器外科学会総会
Place of Presentation
郡山市
Year and Date
2014-07-16 – 2014-07-18
Related Report
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