Development of a new treatment for small-for-size liver graft injury after living donor liver transplantation by bone morphogenetic protein (BMP)-7.

• Project/Area Number: 24591995
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Chiba University
• Principal Investigator: TAKAYASHIKI TSUKASA 千葉大学, 医学部附属病院, 助教 (30456024)
• Co-Investigator(Kenkyū-buntansha): YOSHITOMI Hideyuki 千葉大学, 医学部附属病院, 講師 (60375631) ; KATO Atsushi 千葉大学, 大学院医学研究院, 講師 (70344984) ; SHIMIZU Hiroaki 千葉大学, 大学院医学研究院, 准教授 (80272318) ; MIYAZAKI Masaru 千葉大学, 大学院医学研究院, 教授 (70166156)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 肝臓病学 / 移植・再生医療

Outline of Final Research Achievements

In this study, we revealed that bone morphogenetic protein (BMP)-7 has protective effect for small-for-size (SFS) liver graft injury in rat SFS liver transplantation. Our data and further elucidation of a mechanism of BMP-7 function contribute to a new treatment for small-for-size liver graft injury after living donor liver transplantation without portal inflow modulation.

Research Products

• [Journal Article] Protective effects of simultaneous splenectomy on small-for-size liver graft injury in rat liver transplantation. (2014)
  • Author(s): Yoichi T, Takayashiki T, Shimizu H, Yoshidome H, Ohtsuka M, Kato A, Yoshitomi H, Furukawa K, Kuboki S, Okamura D, Suzuki D, Nakajima M, Miyazaki M.
  • Journal Title: Transplant International Volume: 27 Issue: 1 Pages: 106-113
  • DOI: 10.1111/tri.12223
  • Peer Reviewed