• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Evaluation of the mechanism of liver regeneration focused on intracellular signal transduction and Non-coding RNA expression

Research Project

Project/Area Number 24592000
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionOsaka University (2014)
Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses (2012-2013)

Principal Investigator

MARUBASHI Shigeru  大阪大学, 医学(系)研究科(研究院), 講師 (20362725)

Co-Investigator(Kenkyū-buntansha) WADA Hiroshi  大阪大学, 大学院医学研究科, 助教 (00572554)
NAGANO Hiroaki  山口大学, 大学院医学系研究科, 教授 (10294050)
KAWAMOTO Koichi  大阪大学, 大学院医学研究科, 特任助教(常勤) (30432470)
KOBAYASHI Shogo  地方独立行政法人大阪府立成人病センター (30452436)
EGUCHI Hidetoshi  大阪大学, 大学院医学研究科, 講師 (90542118)
Research Collaborator INOUE Masahiro  大阪府立成人病センター研究所
KANTO Noriko  大阪府立成人病センター研究所
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords肝再生 / 抗IL-6受容体抗体 / c-Met / 抗IL-6抗体 / IL-6 / MR16-1 / Non-coding RNA / IL6 / HGF
Outline of Final Research Achievements

o investigate the mechanism of liver regeneration, we used anti-mouse IL-6 antibody (MR16-1) in order to block the signal transduction of IL-6. We performed traditional 70% hepatectomy model with or without MR16-1, and obtained regenerated liver and blood samples after certain postoperative period.
Remnant livers were more regenerated in terms of liver weight in MR16-1 group than control at 24 hours after hepatectomy (P=0.035). PCNA/Ki Index was suppressed in MR16-1 group than control group. IL-6, TNFalpha, HGF, and apoptosis index were similar between the two groups.
The results of this study can be developed further in the next stage of research of analyzing intracellular signal transduction for liver regeneration.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi