| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
We examined the function of h-prune, and the role of h-prune in colorectal liver metastasis.
h-prune knocked-down cells revealed lower motility, invasiveness and less frequent expression of epithelial-mesenchymal transition markers. In liver metastasis mouse model, mice injected with h-prune knocked-down cells have significantly more frequent liver metastasis than control mice. The overall survival rate was significantly lower in h-prune-positive cases than in h-prune-negative cases. Multivariate analysis showed that h-prune positivity was the only independent factor related to poor overall survival of patients after curative hepatectomy.These results indicate that h-prune has a critical role in the progression of colorectal liver metastases, and it may be considered a newly defined prognostic factor.
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