Molecular targeting therapy for colorectal liver metastasis

• Project/Area Number: 24592001
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Hiroshima University
• Principal Investigator: KOBAYASHI Tsuyoshi 広島大学, 大学病院, 病院助教 (50528007)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 消化器外科 / 腫瘍外科 / 転移

Outline of Final Research Achievements

We examined the function of h-prune, and the role of h-prune in colorectal liver metastasis.
h-prune knocked-down cells revealed lower motility, invasiveness and less frequent expression of epithelial-mesenchymal transition markers. In liver metastasis mouse model, mice injected with h-prune knocked-down cells have significantly more frequent liver metastasis than control mice. The overall survival rate was significantly lower in h-prune-positive cases than in h-prune-negative cases. Multivariate analysis showed that h-prune positivity was the only independent factor related to poor overall survival of patients after curative hepatectomy.These results indicate that h-prune has a critical role in the progression of colorectal liver metastases, and it may be considered a newly defined prognostic factor.

Research Products

• [Journal Article] Prevention of recurrence after curative treatment for hepatocellular carcinoma. (2013)
  • Author(s): Kobayashi T, Ishiyama K, Ohdan H.
  • Journal Title: Surg Today Volume: 43 Issue: 12 Pages: 1347-1354
  • DOI: 10.1007/s00595-012-0473-5
  • Peer Reviewed
• [Journal Article] Surgical treatment for portosystemic encephalopathy in patients with liver cirrhosis: Occlusion of portosystemic shunt in combination with splenectomy. (2013)
  • Author(s): Tashiro H, Ide K, Amano H, Kobayashi T, Onoe T, Ishiyama K, Kuroda S, Tazawa H, Kono H, Aikata H, Takahashi S, Chayama K, Ohdan H.
  • Journal Title: Hepatol Res Volume: 43 Issue: 3 Pages: 249-254
  • DOI: 10.1111/j.1872-034x.2012.01059.x
  • NAID: 10031183466
  • Peer Reviewed
• [Journal Article] Synchronous double cancers of primary hepatic adenosquamous carcinoma and hepatocellular carcinoma: report of a case. (2013)
  • Author(s): Shimizu S, Oshita A, Tashiro H, Amano H, Kobayashi T, Tanaka M, Arihiro K, Ohdan H.
  • Journal Title: Surg Today Volume: 43 Issue: 4 Pages: 418-423
  • DOI: 10.1007/s00595-012-0346-y
  • NAID: 10031168030
  • Peer Reviewed
• [Journal Article] Attenuation of portal hypertension by continuous portal infusion of PGE1 and immunologic impact in adult-to-adult living-donor liver transplantation. (2013)
  • Author(s): Onoe T, Tanaka Y, Ide K, Ishiyama K, Oshita A, Kobayashi T, Amano H, Tashiro H, Ohdan H.
  • Journal Title: Transplantation Volume: 95 Issue: 12 Pages: 1521-1527
  • DOI: 10.1097/tp.0b013e31829150a4
  • Peer Reviewed
• [Journal Article] Inferior vena cava tumor thrombus that directly infiltrated from paracaval lymph node metastases in a patient with recurrent hepatocellular carcinoma. (2013)
  • Author(s): Imada S, Ishiyama K, Ide K, Kobayashi T, Amano H, Tashiro H, Arihiro K, Aikata H, Chayama K, Ohdan H.
  • Journal Title: World J Surg Oncol Volume: 11 Issue: 1 Pages: 177-177
  • DOI: 10.1186/1477-7819-11-177
  • Peer Reviewed
• [Journal Article] Prognostic significance of antithrombin III levels for outcomes in patients with hepatocellular carcinoma after curative hepatectomy. (2012)
  • Author(s): Iwako H, Tashiro H, Amano H, Tanimoto Y, Oshita A, Kobayashi T, Kuroda S, Tazawa H, Nambu J, Mikuriya Y, Abe T, Ohdan H
  • Journal Title: Ann Surg Oncol Volume: 19 Issue: 9 Pages: 2888-2896
  • DOI: 10.1245/s10434-012-2338-y
  • Peer Reviewed
• [Journal Article] Impact of pegylated interferon therapy on outcomes of patients with hepatitis C virus-related hepatocellular carcinoma after curative hepatic resection (2012)
  • Author(s): Tanimoto Y, Tashiro H, Aikata H, Amano H, Oshita A, Kobayashi T, Kuroda S, Tazawa H, Takahashi S, Itamoto T, Chayama K, Ohdan H
  • Journal Title: Ann Surg Oncol Volume: 19 Issue: 2 Pages: 418-425
  • DOI: 10.1245/s10434-011-1866-1
  • Peer Reviewed
• [Journal Article] A huge metastatic liver tumor from leiomyosarcoma of the inferior vena cava : report of a case (2011)
  • Author(s): Hashimoto M, Kobayashi T, Tashiro H, Amano H, Oshita A, Tanimoto Y, Kuroda S, Tazawa H, Aikata H, Chayama K, Fujii M, Arihiro K, Ohdan H
  • Journal Title: Surg Today (Epub 30 Nov.) Volume: (Epub) Issue: 5 Pages: 505-508
  • DOI: 10.1007/s00595-011-0070-z
  • NAID: 10030621850
  • Peer Reviewed
• [Presentation] Role of h-prune in Colorectal Liver Metastases (2014)
  • Author(s): Masakazu Hashimoto, Tsuyoshi Kobayashi, Hirotaka Tashiro, Shintaro Kuroda, Yoshihiro Mikuriya, Akira Kikuchi, Hideki Ohdan
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 大腸癌肝転移に対するh-pruneの役割 (2014)
  • Author(s): 橋本 昌和, 小林 剛, 田代 裕尊, 黒田 慎太郎, 御厨 美洋, 有廣 光司, 大段 秀樹
  • Organizer: 第26回日本肝胆膵外科学会学術集会
  • Place of Presentation: 和歌山県民文化会館
  • Year and Date: 2014-06-11 – 2014-06-13
• [Presentation] 大腸癌肝転移の予後因子としてのh-prune (2014)
  • Author(s): 橋本 昌和, 小林 剛, 田代 裕尊, 黒田 慎太郎, 楠部 潤子, 御厨 美洋, 菊池 章, 大段 秀樹
  • Organizer: 第114回日本外科学会定期学術集会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2014-04-03 – 2014-04-05
• [Presentation] 肝細胞癌の系統的切除または部分切除 5cm以下単発肝細胞癌に対する肝予備能に応じた術式選択 (2013)
  • Author(s): 小林剛，田代 裕尊, 天野 尋暢, 石山 宏平, 井手 健太郎, 大平 真裕, 田澤 宏文, 楠部 潤子, 御厨 美洋, 安部 智之, 橋本 昌和, 大段 秀樹
  • Organizer: 第25回日本肝胆膵外科学会・学術集会
  • Place of Presentation: 宇都宮
• [Presentation] 甲状腺未分化癌の浸潤転移機構におけるh-pruneの役割 (2013)
  • Author(s): 楠部潤子, 小林剛, 田代裕尊, 杉野圭三, 嶋本文雄, 菊地章, 大段秀樹
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] 甲状腺未分化癌の浸潤・転移におけるh-pruneの機能解析 (2012)
  • Author(s): 楠部 潤子, 小林 剛, 田代 裕尊, 杉野 圭三, 嶋本 文雄, 大段 秀樹
  • Organizer: 第24回日本内分泌外科学会総会
  • Place of Presentation: 名古屋
• [Presentation] 肝内胆管癌における肝細胞癌重複例の検討 (2012)
  • Author(s): 橋本 昌和, 小林 剛, 田代 裕尊, 天野 尋暢, 石山 宏平, 井手 健太郎, 田澤 宏文, 楠部 潤子, 御厨 美洋, 安部 智之, 大段 秀樹
  • Organizer: 第74回日本臨床外科学会総会
  • Place of Presentation: 東京
• [Presentation] 5cm以下単発肝細胞癌に対する肝部分切除と肝亜区域切除 (2012)
  • Author(s): 小林 剛, 田代 裕尊, 天野 尋暢, 田澤 宏文, 黒田 慎太郎, 楠部 潤子, 安部 智之, 御厨 美洋, 橋本 昌和, 大段 秀樹
  • Organizer: 第24回日本肝胆膵外科学会・学術集会
  • Place of Presentation: 大阪