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The control of humoral rejection after liver transplantation by modulation of donor specific antibodies.

Research Project

Project/Area Number 24592011
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionTokyo Medical University

Principal Investigator

KAWACHI Shigeyuki  東京医科大学, 医学部, 教授 (80234079)

Co-Investigator(Kenkyū-buntansha) TANAKA Masayuki  慶應義塾大学, 医学部, 助教 (30573414)
FUCHIMOTO Yasushi  独立行政法人国立成育医療研究センター, その他部局等, 小児外科科長 (40219077)
TANABE Minoru  慶應義塾大学, 医学部, 講師 (50197513)
SHINODA Masahiro  慶應義塾大学, 医学部, 講師 (50286499)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords肝移植 / 腎移植 / 生体肝移植 / 液性拒絶反応 / ドナー特異的抗体 / 7th day syndrome / 術前クロスマッチ検査 / Luminex法
Outline of Final Research Achievements

Humoral rejection (HR) is one of the most important complications in liver or renal transplantation. Detection of donor specific antigen (DSA) is thought to be the clue for finding high risk patients for HR, however, only lymphocyte crossmatch test was performed preoperatively and detection of DSA had never done before liver transplantation. We examined perioperative DSA and discuss the clinical significance of preoperative and de novo DSA in liver or renal transplantation.
Our results revealed that only preoperative DSA might be the predictor for HR and lymphocyte crossmatch tests had never linked to preoperative DSA. Our results also demonstrated that de novo DSA had never detected in our series of liver or renal transplantation and clinical significance of de novo DSA had been unclear. We concluded that detection of preoperative DSA might be one of the important prophylaxis for HR after liver or renal transplantation.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (11 results)

All 2014 2013 2012

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (9 results)

  • [Journal Article] 術前画像診断のポイントと術中解剖認識 肝胆膵脾臓疾患2013

    • Author(s)
      河地茂行、佐野 達、沖原正章、高野公徳、千葉斉一、阿部雄太、島津元秀
    • Journal Title

      臨床外科

      Volume: 68巻11号 Pages: 235-240

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 術後の門脈血栓・閉塞 治療のコツ(解説/特集)2013

    • Author(s)
      河地茂行、島津元秀
    • Journal Title

      臨床外科

      Volume: 68 Pages: 172-176

    • Related Report
      2012 Research-status Report
  • [Presentation] 脳死肝移植待機中に生体肝移植を施行した急性肝不全の一例2014

    • Author(s)
      高野公徳、河地茂行、千葉斉一、佐野 達、沖原正章、島津元秀
    • Organizer
      第50回日本腹部救急医学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Clinical feature and etiology of seventh-day syndrome following living donor liver transplantation2014

    • Author(s)
      Shigeyuki Kawachi, Minoru Tanabe, Hideaki Obara, Masahiro Shinoda, Naokazu Chiba, Kiminori Takano, Toru Sano, Masaaki Okihara, Yuko Kitagawa, Motohide Shimazu
    • Organizer
      IHPBA Seoul
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] Pathogenesis and clinical features of seventh-day syndrome after adult living donor liver transplantation2014

    • Author(s)
      Shigeyuki Kawachi, Minoru Tanabe, Hideaki Obara, Masahiro Shinoda, Naokazu Chiba, Kiminori Takano, Toru Sano, Masaaki Okihara, Yuko Kitagawa, Motohide Shimazu
    • Organizer
      World Transplant Congress 2014
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 成人生体肝移植後約1週間で発症する急激なグラフト肝障害の病因2013

    • Author(s)
      河地茂行、田邉 稔、尾原秀明、篠田昌宏、高野公徳、千葉斉一、中村有紀、岩本 整、北川雄光、島津元秀
    • Organizer
      第49回日本移植学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Research-status Report
  • [Presentation] 予期せぬ液性拒絶反応で失った生体肝移植を施行した一例2013

    • Author(s)
      河地茂行、千葉斉一、高野公徳、佐野 達、沖原正章、岩本 整、中村有紀、篠田昌宏、北川雄光、田邉 稔、島津元秀
    • Organizer
      第4回日本臓器保存生物医学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 生体肝移植左葉系グラフト採取術における内視鏡補助による開腹創短縮の試み2012

    • Author(s)
      篠田昌宏、田邉 稔、河地茂行、他11名
    • Organizer
      第25回日本内視鏡外科学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 生体肝移植ドナー手術における胆管断端縫合閉鎖法の改良とその有用性2012

    • Author(s)
      河地茂行、田邉 稔、島津元秀、他7名
    • Organizer
      第48回移植学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] 成人生体肝移植において血液型一致かつリンパ球クロスマッチ陰性にもかかわらず液性拒絶反応で死亡した2症例の検討2012

    • Author(s)
      田中真之、河地茂行、田邉 稔、他12名
    • Organizer
      第112回日本外科学会定期学術集会
    • Place of Presentation
      幕張
    • Related Report
      2012 Research-status Report
  • [Presentation] 予期できない液性拒絶反応によってグラフト不全が疑われた2例2012

    • Author(s)
      河地茂行、田邉 稔、篠田昌宏、他8名
    • Organizer
      第30回日本肝移植研究会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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