The control of humoral rejection after liver transplantation by modulation of donor specific antibodies.
| Project/Area Number |
24592011
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Masayuki 慶應義塾大学, 医学部, 助教 (30573414)
FUCHIMOTO Yasushi 独立行政法人国立成育医療研究センター, その他部局等, 小児外科科長 (40219077)
TANABE Minoru 慶應義塾大学, 医学部, 講師 (50197513)
SHINODA Masahiro 慶應義塾大学, 医学部, 講師 (50286499)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 肝移植 / 腎移植 / 生体肝移植 / 液性拒絶反応 / ドナー特異的抗体 / 7th day syndrome / 術前クロスマッチ検査 / Luminex法 |
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| Outline of Final Research Achievements |
Humoral rejection (HR) is one of the most important complications in liver or renal transplantation. Detection of donor specific antigen (DSA) is thought to be the clue for finding high risk patients for HR, however, only lymphocyte crossmatch test was performed preoperatively and detection of DSA had never done before liver transplantation. We examined perioperative DSA and discuss the clinical significance of preoperative and de novo DSA in liver or renal transplantation.
Our results revealed that only preoperative DSA might be the predictor for HR and lymphocyte crossmatch tests had never linked to preoperative DSA. Our results also demonstrated that de novo DSA had never detected in our series of liver or renal transplantation and clinical significance of de novo DSA had been unclear. We concluded that detection of preoperative DSA might be one of the important prophylaxis for HR after liver or renal transplantation.
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Report
(4 results)
Research Products
(11 results)
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[Presentation] Clinical feature and etiology of seventh-day syndrome following living donor liver transplantation2014
Author(s)
Shigeyuki Kawachi, Minoru Tanabe, Hideaki Obara, Masahiro Shinoda, Naokazu Chiba, Kiminori Takano, Toru Sano, Masaaki Okihara, Yuko Kitagawa, Motohide Shimazu
Organizer
IHPBA Seoul
Place of Presentation
Seoul, Korea
Related Report
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[Presentation] Pathogenesis and clinical features of seventh-day syndrome after adult living donor liver transplantation2014
Author(s)
Shigeyuki Kawachi, Minoru Tanabe, Hideaki Obara, Masahiro Shinoda, Naokazu Chiba, Kiminori Takano, Toru Sano, Masaaki Okihara, Yuko Kitagawa, Motohide Shimazu
Organizer
World Transplant Congress 2014
Place of Presentation
San Francisco, USA
Related Report
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