Early DNA damage response in residual carcinoma in situ at ductal stumps and local recurrence in patients undergoing resection for extrahepatic cholangiocarcinoma
| Project/Area Number |
24592021
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUDA Yasunobu 新潟大学, 医歯学系, 准教授 (40334669)
AJIOKA Yoichi 新潟大学, 医歯学系, 教授 (80222610)
KOYAMA Yu 新潟大学, 医歯学系, 教授 (10323966)
NAGAHASHI Masayuki 新潟大学, 医歯学系, 助教 (30743918)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 早期DNA損傷修復機構 / 胆管癌 / 表層拡大進展 / p53-binding protein 1 / field carcinogenesis / DNA損傷修復機構 / 上皮内癌 / γ-H2AX / DNA二重鎖切断 |
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| Outline of Final Research Achievements |
Clinically evident local recurrence of residual carcinoma in situ at ductal stumps is closely associated with 53BP1 inactivation and decreased apoptosis. In contrast, apoptosis associated with early 53BP1-mediated DNA damage response is one of the molecular biological mechanisms that permit a small proportion of patients with residual carcinoma in situ at ductal stumps to survive in the long term with no evidence of local recurrence. Based on the Early DNA damage response, 50% of patients with formation of intraepithelial spread of invasive carcinoma, whereas 50% of patients with formation of field carcinogenesis. The formation of superficial intraepithelial spread results from both intraepithelial spread of invasive carcinoma and field carcinogenesis.
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Report
(4 results)
Research Products
(4 results)
