Immunological effect of myeloid-derived suppressor cells in pancreatic cancer patients and its alteration after treatment

• Project/Area Number: 24592035
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Fukushima Medical University
• Principal Investigator: KENJO Akira 福島県立医科大学, 医学部, 准教授 (40305355)
• Co-Investigator(Kenkyū-buntansha): TSUCHIYA Takao 福島県立医科大学, 医学部, 博士研究員 (70343390) ; ANAZAWA Takayuki 福島県立医科大学, 医学部, 助教 (90566811) ; GOTOH Mitsukazu 福島県立医科大学, 医学部, 教授 (50162160)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 免疫療法 / 担癌状態 / MDSC / 膵癌 / 骨髄由来抑制細胞

Outline of Final Research Achievements

We evaluated the immune environment of pancreatic cancer patients focusing on myeloid-derived suppressor cells (MDSCs) and analyzed its changes after treatment. Not only pancreatic cancer patients but also hepatobiliary cancer patients had significantly large number of MDSCs compared to healthy volunteers. In biliary cancer patients, the number of MDSCs has been reduced after resection.
Focusing on chronic inflammatory conditions, we evaluated serum soluble IL-2 receptor (sIL-2R) levels in tumor-bearing patients. In hepatobiliary and pancreatic cancer patients, sIL-2R levels were significantly higher than health volunteers. In addition, sIL-2 levels were significantly correlated with serum CRP levels and significantly inversely correlated with immune response indicators (PHA-blastogenesis and IFN-γ induction) and patient nutritional status (transferrin). MDSCs was suggested to be associated with systemic inflammatory conditions and nutritional status of the cancer bearing patients.

Research Products

• [Journal Article] Increased IL-17 production correlates with immunosuppression involving myeloid-derived suppressor cells and nutritional impairment in patients with various gastrointestinal cancers. (2013)
  • Author(s): Yazawa T, Shibata M, Gonda K, Machida T, Suzuki S, Kenjo A, Nakamura I, Tsuchiya T, Koyama Y, Sakurai K, Shimura T, Tomita R, Ohto H, Gotoh M, Takenoshita S.
  • Journal Title: Oncol Lett. Volume: 1 Pages: 1682-1686
  • DOI: 10.3892/mco.2013.134
  • Peer Reviewed
• [Journal Article] Serum levels of vascular endothelial growth factor are increased and correlate with malnutrition, immunosuppression involving MDSCs and systemic inflammation in patients with cancer of the digestive system. (2013)
  • Author(s): Nakamura I, Shibata M, Gonda K, Yazawa T, Shimura T, Anazawa T, Suzuki S, Sakurai K, Koyama Y, Ohto H, Tomita R, Gotoh M, Takenoshita S.
  • Journal Title: Oncology Letters Volume: 5 Pages: 1682-1686
  • DOI: 10.3892/ol.2013.1231
  • Peer Reviewed
• [Journal Article] Phase I trial of preoperative intratumoral injection of immature dendritic cells and OK-432 for resectable pancreatic cancer patients. (2012)
  • Author(s): Endo H
  • Journal Title: J Hepatobiliary Pancreatic Science Volume: 19(4) Pages: 465-475
  • DOI: 10.1007/s00534-011-0457-7
  • Peer Reviewed
• [Presentation] Serum soluble IL-2 receptor is increased in malnutrished immunosuppressed patients with hepato-pancreatic carcinomas. (2012)
  • Author(s): 見城 明
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌