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Immunological effect of myeloid-derived suppressor cells in pancreatic cancer patients and its alteration after treatment

Research Project

Project/Area Number 24592035
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionFukushima Medical University

Principal Investigator

KENJO Akira  福島県立医科大学, 医学部, 准教授 (40305355)

Co-Investigator(Kenkyū-buntansha) TSUCHIYA Takao  福島県立医科大学, 医学部, 博士研究員 (70343390)
ANAZAWA Takayuki  福島県立医科大学, 医学部, 助教 (90566811)
GOTOH Mitsukazu  福島県立医科大学, 医学部, 教授 (50162160)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords免疫療法 / 担癌状態 / MDSC / 膵癌 / 骨髄由来抑制細胞
Outline of Final Research Achievements

We evaluated the immune environment of pancreatic cancer patients focusing on myeloid-derived suppressor cells (MDSCs) and analyzed its changes after treatment. Not only pancreatic cancer patients but also hepatobiliary cancer patients had significantly large number of MDSCs compared to healthy volunteers. In biliary cancer patients, the number of MDSCs has been reduced after resection.
Focusing on chronic inflammatory conditions, we evaluated serum soluble IL-2 receptor (sIL-2R) levels in tumor-bearing patients. In hepatobiliary and pancreatic cancer patients, sIL-2R levels were significantly higher than health volunteers. In addition, sIL-2 levels were significantly correlated with serum CRP levels and significantly inversely correlated with immune response indicators (PHA-blastogenesis and IFN-γ induction) and patient nutritional status (transferrin). MDSCs was suggested to be associated with systemic inflammatory conditions and nutritional status of the cancer bearing patients.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report

Research Products

(4 results)

All 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (1 results)

  • [Journal Article] Increased IL-17 production correlates with immunosuppression involving myeloid-derived suppressor cells and nutritional impairment in patients with various gastrointestinal cancers.2013

    • Author(s)
      Yazawa T, Shibata M, Gonda K, Machida T, Suzuki S, Kenjo A, Nakamura I, Tsuchiya T, Koyama Y, Sakurai K, Shimura T, Tomita R, Ohto H, Gotoh M, Takenoshita S.
    • Journal Title

      Oncol Lett.

      Volume: 1 Pages: 1682-1686

    • DOI

      10.3892/mco.2013.134

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Serum levels of vascular endothelial growth factor are increased and correlate with malnutrition, immunosuppression involving MDSCs and systemic inflammation in patients with cancer of the digestive system.2013

    • Author(s)
      Nakamura I, Shibata M, Gonda K, Yazawa T, Shimura T, Anazawa T, Suzuki S, Sakurai K, Koyama Y, Ohto H, Tomita R, Gotoh M, Takenoshita S.
    • Journal Title

      Oncology Letters

      Volume: 5 Pages: 1682-1686

    • DOI

      10.3892/ol.2013.1231

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phase I trial of preoperative intratumoral injection of immature dendritic cells and OK-432 for resectable pancreatic cancer patients.2012

    • Author(s)
      Endo H
    • Journal Title

      J Hepatobiliary Pancreatic Science

      Volume: 19(4) Pages: 465-475

    • DOI

      10.1007/s00534-011-0457-7

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Serum soluble IL-2 receptor is increased in malnutrished immunosuppressed patients with hepato-pancreatic carcinomas.2012

    • Author(s)
      見城 明
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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