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Treatment strategy of pancreatic cancer based on genome-wide profile

Research Project

Project/Area Number 24592037
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionWakayama Medical University

Principal Investigator

HIRONO Seiko  和歌山県立医科大学, 医学部, 講師 (60468288)

Co-Investigator(Kenkyū-buntansha) YAMAUE Hiroki  和歌山県立医科大学, 医学部, 教授 (20191190)
TANI Mesuji  和歌山県立医科大学, 医学部, 准教授 (60236677)
KAWAI Manabu  和歌山県立医科大学, 医学部, 講師 (40398459)
OKADA Ken-ichi  和歌山県立医科大学, 医学部, 助教 (50407988)
MIYAZAWA Motoki  和歌山県立医科大学, 医学部, 学内助教 (90549734)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords網羅的遺伝子解析 / 包括的DNA1次構造異常解析 / 膵癌 / DNA1次構造異常 / 網羅的遺伝子発現解析 / homozygous deletion / LOH / 膵臓外科
Outline of Final Research Achievements

We identified specific copy number variants and heterogenous deletion for pancreatic cancer by GeneChip Mapping array 100K and expression profile by GeneChip Human Genome U133 plus 2.0 array, using DNA and RNA extracted from harvest the pancreatic cancer cells by microdissection. We identified 6 regions, including Ch 9p21.3, Ch 18q21.1, of homozygous deletion, and many regions of heterogenous deletion. The RNA expression of CDKN2A gene, which is located in Ch 9p21.3, and SMAD4, which is located in Ch 18q21.1, were none in homozygous deletion samples. However the RNA expression of these genes were various in heterogenous deletion samples. We also identified some specific amplification regions and we found that the RNA expression of the genes which is located in these regions increased in amplification samples, compared to other samples.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (6 results)

All 2014 2013

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Indication for the use of an interposed graft during portal vein and/or superior mesenteric vein reconstruction in pancreatic resection based on perioperative outcomes2014

    • Author(s)
      Seiko Hirono, Manabu Kawai, Masaji Tani, Ken-ichi Okada, Motoki Miyazawa, Atsushi Shimizu, Hiroki Yamaue
    • Journal Title

      Langenbeck Arch Surg

      Volume: 未 Issue: 4 Pages: 461-471

    • DOI

      10.1007/s00423-014-1182-x

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phase II clinical study of alternate-day oral therapy with S-1 as first-line chemotherapy for locally advanced and metastatic pancreatic cancer2014

    • Author(s)
      Yamaue H, et al
    • Journal Title

      Cancer Chemother Pharmacol

      Volume: 73(1) Issue: 1 Pages: 97-102

    • DOI

      10.1007/s00280-013-2323-6

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of adjuvant surgery for patients with initially unresectable pancreatic cancer with a long-term favorable response to non-surgical anti-cancer treatments: results of a project study for pancreatic surgery by the Japanese Society of Hepato-Biliary-Pancreatic Surgery.2013

    • Author(s)
      Satoi S, Yamaue H, Kato K, Takahashi S, Hirono S, Takeda S, Eguchi H, Sho M, Wada K, Shinchi H, Kwon AH, Hirano S, Kinoshita T, Nakao A, Nagano H, Nakajima Y, Sano K, Miyazaki M, Takada T
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 20 Issue: 6 Pages: 590-600

    • DOI

      10.1007/s00534-013-0616-0

    • NAID

      10031194615

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Surgical strategy for patients with pancreatic body/tail carcinoma: who should undergo distal pancreatectomy with en-bloc celiac axis resection?2013

    • Author(s)
      Okada K
    • Journal Title

      Surgery

      Volume: 153 Issue: 3 Pages: 365-372

    • DOI

      10.1016/j.surg.2012.07.036

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Identification of the genes associated with the invasion process and prognosis for pancreatic ductal adenocarcinoma: coexpression of MUC16 and mesothelin2014

    • Author(s)
      Seiko Hirono
    • Organizer
      DDW 2014
    • Place of Presentation
      仙台
    • Year and Date
      2014-05-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 包括的DNA一次構造異常解析と遺伝子発現プロファイルから導いた新規膵癌治療戦略2013

    • Author(s)
      廣野誠子、谷 眞至、川井 学、岡田健一、宮澤基樹、清水敦史、北畑裕司、山上裕機
    • Organizer
      日本膵臓学会
    • Place of Presentation
      仙台
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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