Treatment strategy of pancreatic cancer based on genome-wide profile
| Project/Area Number |
24592037
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
HIRONO Seiko 和歌山県立医科大学, 医学部, 講師 (60468288)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAUE Hiroki 和歌山県立医科大学, 医学部, 教授 (20191190)
TANI Mesuji 和歌山県立医科大学, 医学部, 准教授 (60236677)
KAWAI Manabu 和歌山県立医科大学, 医学部, 講師 (40398459)
OKADA Ken-ichi 和歌山県立医科大学, 医学部, 助教 (50407988)
MIYAZAWA Motoki 和歌山県立医科大学, 医学部, 学内助教 (90549734)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 網羅的遺伝子解析 / 包括的DNA1次構造異常解析 / 膵癌 / DNA１次構造異常 / 網羅的遺伝子発現解析 / homozygous deletion / LOH / 膵臓外科 |
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| Outline of Final Research Achievements |
We identified specific copy number variants and heterogenous deletion for pancreatic cancer by GeneChip Mapping array 100K and expression profile by GeneChip Human Genome U133 plus 2.0 array, using DNA and RNA extracted from harvest the pancreatic cancer cells by microdissection. We identified 6 regions, including Ch 9p21.3, Ch 18q21.1, of homozygous deletion, and many regions of heterogenous deletion. The RNA expression of CDKN2A gene, which is located in Ch 9p21.3, and SMAD4, which is located in Ch 18q21.1, were none in homozygous deletion samples. However the RNA expression of these genes were various in heterogenous deletion samples. We also identified some specific amplification regions and we found that the RNA expression of the genes which is located in these regions increased in amplification samples, compared to other samples.
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Role of adjuvant surgery for patients with initially unresectable pancreatic cancer with a long-term favorable response to non-surgical anti-cancer treatments: results of a project study for pancreatic surgery by the Japanese Society of Hepato-Biliary-Pancreatic Surgery.2013
Author(s)
Satoi S, Yamaue H, Kato K, Takahashi S, Hirono S, Takeda S, Eguchi H, Sho M, Wada K, Shinchi H, Kwon AH, Hirano S, Kinoshita T, Nakao A, Nagano H, Nakajima Y, Sano K, Miyazaki M, Takada T
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Journal Title
J Hepatobiliary Pancreat Sci
Volume: 20
Issue: 6
Pages: 590-600
DOI
NAID
Related Report
Peer Reviewed
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