| Project/Area Number |
24592049
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
KAWAMOTO SYUNSUKE 東北大学, 医学(系)研究科(研究院), 准教授 (20400244)
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| Co-Investigator(Kenkyū-buntansha) |
SAIKI Yoshikatsu 東北大学, 医学系研究科, 教授 (50372298)
MOTOYOSHI Naotaka 東北大学, 大学病院, 講師 (40375093)
NAKAGAWA Atsuhiro 東北大学, 大学病院, 助手 (10447162)
NAKANO Toru 東北大学, 大学病院, 助手 (50451571)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 冠動脈バイパス術 / ジェットメス / 内胸動脈剥離 / 冠動脈露出 / 心筋内走行 / 熱損傷 / 循環器・高血圧 / 心臓血管外科学 / パルスジェットメス / 感動脈バイパス手術 / 冠動脈バイパス手術 |
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| Outline of Final Research Achievements |
An application of actuator-driven pulsed water jet (ADPJ) to coronary artery bypass grafting surgery, especially graft harvesting and coronary artery exposing, was investigated, because this device do not have any risk of heat injury. After confirming the mechanical property of ADPJ, the tissue strength of swine target vessels and their surrounding tissues were measured. The breaking strength of internal thoracic artery and that of surrounding tissue were significantly different, and this difference was also confirmed between coronary artery and cardiac muscle. This fact shows theoretical basis of tissue selective dissection ability by ADPJ. Actual harvesting of internal thoracic artery and exposure of coronary artery embedded in cardiac muscle were experienced using swine model. Histological evaluation revealed the successful dissection and exposure of target vessels without apparent damages, and indicated the possibility of clinical application and better outcome.
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