Experimental study on the risks of mal-pefusion in contemporary pediatric cardio-pulmonary bypass system
| Project/Area Number |
24592053
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | University of Yamanashi |
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Principal Investigator |
SUZUKI Shoji 山梨大学, 総合研究部, 准教授 (30235949)
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| Co-Investigator(Kenkyū-buntansha) |
KAGA Shigeaki 山梨大学, 総合研究部, 助教 (10422693)
MATSUMOTO Masahiko 山梨大学, 総合研究部, 教授 (30372501)
SAKAKIBARA Kenji 山梨大学, 総合研究部, 助教 (40419338)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 小児用人工心肺 / 潅流障害 / 充填液アルカリ化 / 人工心肺潅流障害 / 小児用膜型人工肺 / 小児人工心肺 / 医療安全 |
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| Outline of Final Research Achievements |
Mal-perfusion in contemporary pediatric cardio-pulmonary bypass (CPB) system has been occasionally found. We focused on alkalization of the priming solution induced by usual priming procedures which may lead to unexpected haemagglutination. By using recirculating circuit with a membrane oxygenator, hydrogen power (pH) of the various priming solutions, which were Lactate Ringer, Acetate Ringer, Bicarbonate Ringer, Hemodyalisate, and the various oxygenators, which were CX-FX05RW, HPO-06H-C, JK-JMOXIAIC06, D100-50534, ME62050061, BIOCUBEC2000, were studied.
The results concluded that any combinations of the solutions and equipment may lead to excessive alkalization of the priming solution which may be one of the factors of mal-perfusion. In particular, gas insufflation during priming accelerates and increases the risks. Reconsideration of the priming procedures for pediatric CPB is highly recommended.
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Report
(5 results)
Research Products
(2 results)
