Development of an easy and reliable method to monitor spinal cord function
| Project/Area Number |
24592056
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Research Collaborator |
TSUDA Kazumasa
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 運動誘発電位 / 脊髄虚血 / 大動脈外科手術 / 大動脈手術 / 脊髄虚血障害 / 誘発電位 / 虚血性脊髄障害 |
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| Outline of Final Research Achievements |
To prevent ischemic spinal cord injury during aortic surgery, trans-cranial motor evoked potentials monitoring has been widely used, which has high false positive rate due to low stability and is poorly correlated with neurological outcomes. The present study was undertaken to establish a monitoring method with high sensitivity and specificity by spinal cord electrical stimulation through a esophageal surface electrodes.
Using a home-made stimulation electrode, we first confirmed its feasibility and safety, and found that trans-esophageal motor evoked potentials are superior to trans-cranial motor evoked potentials in amplitude stability.
Using a model of descending aortic balloon occlusion, we then evaluated its response to spinal cord ischemia, and found that trans-esophageal stimulation is superior to trans-cranial stimulation in terms of quicker response to spinal cord ischemia and better correlation with neurological outcomes.
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Report
(5 results)
Research Products
(9 results)
