| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
To prevent ischemic spinal cord injury during aortic surgery, trans-cranial motor evoked potentials monitoring has been widely used, which has high false positive rate due to low stability and is poorly correlated with neurological outcomes. The present study was undertaken to establish a monitoring method with high sensitivity and specificity by spinal cord electrical stimulation through a esophageal surface electrodes.
Using a home-made stimulation electrode, we first confirmed its feasibility and safety, and found that trans-esophageal motor evoked potentials are superior to trans-cranial motor evoked potentials in amplitude stability.
Using a model of descending aortic balloon occlusion, we then evaluated its response to spinal cord ischemia, and found that trans-esophageal stimulation is superior to trans-cranial stimulation in terms of quicker response to spinal cord ischemia and better correlation with neurological outcomes.
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