| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The evaluation of right ventricular function is not fully established because of the anatomical complexity of the right ventricle. The aims of the present study are to establish an animal model of pulmonary regurgitation and to clarify the relationship between functional and histological changes of the right ventricle. We succeeded to induce significant pulmonary regurgitation in canine model by placing some stitches from outside of pulmonary root to fix the pulmonary valve. After 3 months of observation, significant right ventricular dilatation developed, whereas no significant changes were observed in histological examination. Although additional study with longer observation period is necessary, this animal model could be used in investigating therapeutic approaches to treat chronic right ventricular dysfunction
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