New theraputic strategy to treat abdominal aortic anerysm via mechano-stress reguratory factor: periostin
| Project/Area Number |
24592063
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
JUNYA AZUMA 大阪大学, 医学(系)研究科(研究院), 特任助教 (20614671)
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| Co-Investigator(Kenkyū-buntansha) |
TANIYAMA Yoshiaki 大阪大学, 大学院医学系研究科, 寄附講座准教授 (60372611)
眞田 文博 大阪大学, 医学(系)研究科(研究院), 助教 (30722227)
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| Co-Investigator(Renkei-kenkyūsha) |
SANADA Fumihiro 大阪大学, 大学院医学系研究科, 寄附講座特任助教 (30722227)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 腹部動脈瘤 / メカニカルストレス / 動脈瘤 / 川崎病 / ぺリオスチン / 腹部大動脈瘤 |
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| Outline of Final Research Achievements |
Abdominal aortic aneurysm (AAA) has complex hemodynamics which leads various mechanical stresses in aortic wall. Periostin (PN) is a matricellular protein that is induced by mechanostress and regulates organ remodeling. Our previous genome transcriptional profiling of the murine angiotensin II (Ang II) induced AAA have shown 3.5-fold up-regulation of PN in AAA in early remodeling phase over saline-control sample. Moreover we also found it was highly expressed in human AAA samples. The purpose of the present study was to investigate the potential role of PN in AAA disease progression.
PN was significantly unregulated in early remodeling phase of AAAs and its ablation contributed to reduce AAA growth. Antagonists against PN will potentially lead to new therapeutic targets on a molecular basis to limit AAA disease progression.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development.2014
Author(s)
Maegdefessel L, Spin JM, Raaz U, Eken SM, Toh R, Azuma J, Adam M, Nagakami F, Heymann HM, Chernugobova E, Jin H, Roy J, Hultgren R, Caidahl K, Schrepfer S, Hamsten A, Eriksson P, McConnell MV, Dalman RL, Tsao PS.
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Journal Title
Nat Commun
Volume: 5
Issue: 1
Pages: 5214-5214
DOI
Related Report
Peer Reviewed
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[Journal Article] Novel mechanism of hepatocyte growth factor against prevention of inflammation and oxidative stress2013
Author(s)
Shimizu K, Taniyama Y, Sanada F, Iwabayashi M, Azuma J, Iekushi K, Katsuragi N, Otsu R, Shibata K, Ishikawa Y, Rakugi H, Morishita R
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Journal Title
Inflammation and Regeneration
Volume: 33（3）
Pages: 136-142
NAID
Related Report
Peer Reviewed
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[Presentation] ニコチンによる腹部動脈瘤の増悪とマイクロRNA-21の関連の検討2014
Author(s)
東 純哉, Lars Maegdefessel, 杜 隆嗣, Michael V. McConnell, Ronald L. Dalman, Joshua M. Spin, 森下竜一, Philip S. Tsao
Organizer
第14回日本抗加齢医学会総会
Place of Presentation
(6.6 大阪)
Year and Date
2014-06-06 – 2014-06-08
Related Report
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