Pharmaceutical treatment for abdominal aortic aneurysms in rats
| Project/Area Number |
24592064
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Kobe University |
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Principal Investigator |
OKADA Kenji 神戸大学, 医学(系)研究科(研究院), 研究員 (90284356)
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| Co-Investigator(Kenkyū-buntansha) |
OKITA Yutaka 神戸大学, 医学(系)研究科(研究院), 教授 (40322193)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 大動脈瘤 / 薬物治療 |
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| Outline of Final Research Achievements |
An ideal pharmaceutical treatment for abdominal aortic aneurysm (AAA) is to prevent aneurysm formation and development (further dilatation of pre-existing aneurysm). Recent studies have reported that oxidative stress with reactive oxygen species (ROS) is crucial in aneurysm formation. We have demonstrated that edaravone, a free-radical scavenger, attenuated vascular oxidative stress and inhibit AAA formation and development in rat AAA model. Based on the results, we also have proven the efficacy of other anti-oxidants, such as a gelatin hydrogel sheet incorporating ascorbic acid, a novel oral antidiabetic drug of Dipeptidyl peptidase-4 (DPP-4) inhibitor, and oral administration of riboflavin on the treatment of AAA.
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Report
(4 results)
Research Products
(12 results)
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[Presentation] DPP-4 inhibitor alogliptin inhibits abdominal aortic aneurysm formation and development in rat model2013
Author(s)
Keisuke MORIMOTO, Wulan BAO, Zhenhai YU, Yu JIE, Naoto SASAKI, Tomoya YAMASHITA, Kenichi HIRATA, Yutaka OKITA, Kenji OKADA
Organizer
Arteriosclerosis, Thrombosis and Vascular Biology, Scientific Sessions 2013
Place of Presentation
Florida, USA
Related Report
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[Presentation] ATVB 20132013
Author(s)
Keisuke Morimoto, Wulan Bao, Zhenhai Gyo, Yu Jie, Naoto Sasaki, Tomoya Yamashita, Kenichi Hirata, Yutaka Okita, Kenji Okada
Organizer
DPP-4 Inhibitor Alogliptin Attenuates Abdominal Aortic Aneurysm
Formation and Development in Rat Model
Place of Presentation
米国 オーランド
Related Report
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