Establishment of intraoperative quick diagnostic method using intraoperative simple electrophysiological study and development of lower invasive surgical procedure.

• Project/Area Number: 24592066
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Hiroshima University
• Principal Investigator: IMAI Katsuhiko 広島大学, 大学病院, 講師 (80359893)
• Co-Investigator(Kenkyū-buntansha): SUEDA Taijiro 広島大学, 医歯薬保健学研究院, 教授 (10162835)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: 心房細動 / メイズ手術 / 心臓電気生理学的検査 / 術中マッピング / 心房電位 / スペクトル解析 / 不整脈 / 慢性心房細動 / 電気生理学的検査 / 心臓神経節 / 心房細動手術

Outline of Final Research Achievements

We finalized the development of our unique intraoperative electrode which is fixed by negative pressure on the atrium for simultaneous analysis of the real time atrial potential during fibrillation. (2) Farther, we developed the connector to the AD board and analyzing system on the PC. Then we tested the total system. (3) We have performed simplified procedure which have been modified from Cox maze along with our clinical and electrophysiological experience for chronic atrial fibrillation. This procedure included a denervation for ganglion plexus. We analyzed the clinical outcomes of this procedure.

Research Products

• [Journal Article] Preoperative Tissue Doppler Imaging-Derived Atrial Conduction Time Can Predict Postoperative Atrial Fibrillation in Patients Undergoing Aortic Valve Replacement for Aortic Valve Stenosis (2014)
  • Author(s): Shinya Takahashi, Mai Fujiwara, Keisuke Watadani, Takahiro Taguchi, Keijiro Katayama, Taiichi Takasaki, Tatsuya Kurosaki, Katsuhiko Imai, Taijiro Sueda.
  • Journal Title: Circulation Journal Volume: 78 Issue: 9 Pages: 2173-2181
  • DOI: 10.1253/circj.CJ-14-0327
  • NAID: 130004427972
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] 大動脈弁手術症例における術後心房細動の予測因子に関する検討 (2014)
  • Author(s): 高橋信也，渡邉正済，片山桂次郎，高崎泰一，黒崎達也，今井克彦，末田泰二郎
  • Journal Title: 広島医学 Volume: 67(10) Pages: 675-681
  • Peer Reviewed
• [Journal Article] Prediction of Atrial Fibrillation After Off-Pump Coronary Artery Bypass Grafting Using Preoperative Total Atrial Conduction Time Determined on Tissue Doppler Imaging (2014)
  • Author(s): Mai Fujiwara, Yukiko Nakano, Takayuki Hidaka, Noboru Oda, Yuko Uchimura, Akinori Sairaku, Kenta Kajihara, Takehito Tokuyama, Chikaaki Motoda, Yoshikazu Watanabe, Hiroki Ikenaga, Katsuhiko Imai, Taijirou Sueda, Yasuki Kihara
  • Journal Title: Circulation Journal Volume: 78 Issue: 2 Pages: 345-352
  • DOI: 10.1253/circj.CJ-13-0900
  • NAID: 130003382216
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed
• [Journal Article] Mid-term results of the box pulmonary vein isolation and the cryo-maze procedure for chronic atrial fibrillation associated with mitral valve disease. (2012)
  • Author(s): Takasaki T, Sueda T, Imai K, Orihashi K, Takahashi S, Kurosaki T, Morita S, Uchida N.
  • Journal Title: Gen Thorac Cardiovasc Surg. Volume: Feb;60(2) Pages: 82-89
  • Peer Reviewed
• [Journal Article] Epicardial Atrial Mapping Can Predict Elimination of Chronic Atrial Fibrillation After the Box Pulmonary Vein Isolation During Mitral Valve Surgery. (2012)
  • Author(s): Sueda T, Uchida N, Takahashi S, Takasaki T, Kurosaki T, Katayama K, Imai K.
  • Journal Title: Circ J. Volume: Apl:76(4) Pages: 852-859
  • NAID: 10030131060
  • Peer Reviewed
• [Journal Article] Long-term Results after the Box Pulmonary Vein Isolation Procedure for Chronic Atrial Fibrillation in Mitral Valve Surgery. (2012)
  • Author(s): Sueda T, Uchida N, Takasaki T, Takahashi S, Kurosaki T, Katayama K, Imai K.
  • Journal Title: Ann Thorac Cardiovasc Surg. Volume: 18 Pages: 101-108
  • NAID: 10030625133
  • Peer Reviewed
• [Presentation] All the patients with paroxysmal atrial fibrillation submitted to heart surgery should receive concomitant epicardial pulmonary vein isolation and closure of the left appendage. (2014)
  • Author(s): Katsuhiko Imai
  • Organizer: XVI International Symposium on Progress in Clinical Pacing (Pacing 2014) FORUM "EURO-JAPAN ARRHYTHMIA FORUM (EJAF)
  • Place of Presentation: Rome, Italy
  • Year and Date: 2014-12-02
  • Invited
• [Presentation] 【Joint Symposium: Long Term Outcome of Non-pharmacological Therapy for Atrial Fibrillation】 Follow Up Outcomes of the simple Procedure Using Radiofrequency Device for Permanent/Persistent Atrial Fibrillation: An Alternative Procedure to Cox’s Maze Concept. (2014)
  • Author(s): Katsuhiko Imai, Taijiro Sueda, Masazumi Watanabe, Takahiro Taguchi, Keijiro Katayama, Shinya Takahashi, Taiichi Takasaki, Tatsuya Kurosaki
  • Organizer: The 29th Annual Meeting of the Japanese Heart Rhythm Society
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2014-07-25
• [Presentation] 【Panel Discussion 11: Surgical Strategy for AF Patients with Aortic Valve Disease】 Surgical Strategy for AF Patients with Aortic Valve Disewase: Clinical Outcome of Open PVBI and Close PVBI. (2014)
  • Author(s): Katsuhiko Imai, Taijiro Sueda, Masazumi Watanabe, Takahiro Taguchi, Keijiro Katayama, Shinya Takahashi, Taiichi Takasaki, Tatsuya Kurosaki
  • Organizer: The 29th Annual Meeting of the Japanese Heart Rhythm Society
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2014-07-25
• [Presentation] 【Panel Discussion 9: Prevention and Treatment for Atrial Tachycardia after the Maze Procedure】 Postoperative Atrial Tachycardia following PV Box Isolation for Permanent/Long-standing Atrial Fibrillation. (2014)
  • Author(s): Katsuhiko Imai, Taijiro Sueda, Masazumi Watanabe, Takahiro Taguchi, Keijiro Katayama, Shinya Takahashi, Taiichi Takasaki, Tatsuya Kurosaki
  • Organizer: The 29th Annual Meeting of the Japanese Heart Rhythm Society
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2014-07-24
• [Presentation] 【Panel Discussion 7: Management of Perioperative Arrhythmias in Catheter and Surgical Ablation of Atrial Fibrillation】 Post operative Rhythm Management Following Arrhythmia Surgery for Persistent/Long-standing Atrial Fibrillation Combined with Organic Heart Disease. (2014)
  • Author(s): Katsuhiko Imai, Taijiro Sueda, Masazumi Watanabe, Takahiro Taguchi, Keijiro Katayama, Shinya Takahashi, Taiichi Takasaki, Tatsuya Kurosaki
  • Organizer: The 29th Annual Meeting of the Japanese Heart Rhythm Society
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2014-07-24
• [Presentation] A Simple Procedure Based on Pulmonary Vein Box Isolation Using Radiofrequency Device for Valvular Chronic Atrial Fibrillation Alternative to Cox’s Maze Procedure
  • Author(s): Katsuhiko Imai, Taijiro Sueda, Keijiro Katayama, Shinya Takahashi, Taiichi Takasaki, Tatsuya Kurosaki
  • Organizer: The 28th Annual Meeting of the Japanese Heart Rhythm Society [Panel Discussion]
  • Place of Presentation: Tokyo, Japan
• [Presentation] Minimal Invasive or Total Scopic Maze Surgery
  • Author(s): Katsuhiko Imai
  • Organizer: 6th Asia-Pacific Heart Rhythm Society Science Session (6th APHRS CARDIORHYTHM3013)
  • Place of Presentation: Hong Kong, Special Administrative Region of the People’s Republic of China
  • Invited
• [Presentation] 両房室弁不全合併慢性Ａｆに対する”maze concept”によらない簡易化手術の遠隔期成績
  • Author(s): 今井克彦 ジェコ ナイチョフ 倉岡正嗣 片山桂次郎 高橋信也 高崎泰一 黒崎達也 内田直里 末田泰二郎
  • Organizer: 第４２回日本心臓血管外科学会学術総会 【シンポジウム６】
  • Place of Presentation: 秋田市
• [Presentation] Current Status of Surgical AF Ablation: Less invasive AF Surgical Ablation
  • Author(s): Katsuhiko Imai, Taijiro Sueda
  • Organizer: 5th Asia-Pacific Heart Rhythm Society Science Session (APHRS 2012)
  • Place of Presentation: Taipei, Taiwan
  • Invited
• [Presentation] 慢性心房細動に対する左房メイズ手術：１０年を越えた遠隔成績
  • Author(s): 今井克彦 ジェコ ナイチョフ 倉岡正嗣 片山桂次郎 高橋信也 高崎泰一 黒崎達也 内田直里 末田泰二郎
  • Organizer: 第２６回不整脈外科研究会
  • Place of Presentation: 秋田市
• [Presentation] 左房切開を行わないPV Box Isolation：非僧帽弁疾患に合併する心房細動に対する低侵襲化外科治療戦略
  • Author(s): 今井克彦 ジェコ ナイチョフ 倉岡正嗣 片山桂次郎 高橋信也 高崎泰一 黒崎達也 内田直里 末田泰二郎
  • Organizer: 第６０回日本心臓病学会学術集会
  • Place of Presentation: 金沢市
• [Presentation] 大動脈弁単独疾患に合併する心房細動に対する低侵襲手術：左房切開を行わないpurse-string PV Box Isolation
  • Author(s): 今井克彦 ジェコ ナイチョフ 渡谷啓介 倉岡正嗣 片山桂次郎 高橋信也 高崎泰一 黒崎達也 内田直里 末田泰二郎
  • Organizer: 第６５回日本胸部外科学会定期学術集会
  • Place of Presentation: 福岡市
• [Book] 不整脈概論．池田隆徳・山下武志編，分担執筆 第IV章 治療編 手術療法 (2012)
  • Author(s): 今井克彦
  • Total Pages: 421
  • Publisher: MEDICAL VIWE