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Novel therapeutic strategy for heart failure focusing on mechanical stress

Research Project

Project/Area Number 24592067
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Thoracic surgery
Research InstitutionYamaguchi University

Principal Investigator

SHIRASAWA Bungo  山口大学, 医学(系)研究科(研究院), 准教授 (80444719)

Co-Investigator(Kenkyū-buntansha) HAMANO Kimikazu  山口大学, 大学院医学系研究科, 教授 (60263787)
LI Tao-Sheng  長崎大学, 原爆後障害医療研究所, 教授 (50379997)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsメカニカルストレス / 進展刺激 / 心筋幹細胞 / 細胞移植治療 / 心筋梗塞 / 伸展刺激 / 心臓由来細胞
Outline of Final Research Achievements

In this study, we examined whether mechanical stress affects a behavior of cardiac stem cells (CSCs), because of the fact that higher transplantation efficiency in heart failure patients with a left ventricular assist device. Cell viabilities and proliferation capacity were significantly decreased in stretch-induced human CSCs, while production of angiogenic factors were up-regulated. In addition, transplantation of CSCs into infarcted heart of haemodynamic unloading mouse models showed an increase of transplantation efficiency, resulting in heart regeneration. Taken together, our results indicate that inhibition of mechanical stress might improve an efficiency of cell-based therapy for severe heart failure.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2014 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] Mortality and morbidity after total aortic arch replacement.2014

    • Author(s)
      Tanaka Y, Mikamo A, Suzuki R, Kurazumi H, Kudo T, Takahashi M, Ikenaga S, Shirasawa B, Hamano K.
    • Journal Title

      Ann Thorac Surg

      Volume: 97 Pages: 1569-1575

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aortic arch surgery in octogenarians: is it justified?2014

    • Author(s)
      Kurazumi H, Mikamo A, Kudo T, Suzuki R, Takahashi M, Shirasawa B, Zempo N, Hamano K.
    • Journal Title

      Eur J Cardiothorac Surg

      Volume: 46 Pages: 672-677

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] メカニカルストレスが細胞移植による心筋再生療法に対して及ぼす影響2012

    • Author(s)
      藏澄宏之
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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