| Project/Area Number |
24592068
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KITAGAWA Tetsuya 徳島大学, ヘルスバイオサイエンス研究部, 教授 (80240886)
KITAICHI Takashi 徳島大学, ヘルスバイオサイエンス研究部, 准教授 (20335813)
SUGANO Mikio 徳島大学, 大学病院, 医員 (70563807)
NAKAYAMA Taisuke 徳島大学, 大学病院, 医員 (80582791)
KUROBE Hirotsugu 徳島大学, ヘルスバイオサイエンス研究部, 助教 (30380083)
FUJIMOTO Eiki 徳島大学, ヘルスバイオサイエンス研究部, 助教 (60611225)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 血管リモデリング / マクロファージ / Hif |
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| Outline of Final Research Achievements |
In this study, we clarified the role of macrophage-derived hypoxia-inducible factor (HIF-1α) in vascular remodeling. Wire-induced femoral arterial injury was inflicted in mice lacking the macrophage-specific HIF-1α gene and in their wild-type counterparts. The mutant mice showed both suppressed wire-induced neointimal thickening and decreased infiltration of inflammatory cells in the adventitia, compared to wild-type mice. Studies to clarify the mechanism of restrained vascular remodeling in the mutant mice revealed decreased production of pro-inflammatory cytokines by the activated macrophages and suppressed macrophage migration activity in the mutant mice. Gene expressions of the HIF-1α-deficient macrophages positively correlated with the phenotypic profile of M2 macrophages and negatively correlated with that of M1 macrophages. Our results show that HIF-1α in macrophages plays a crucial role in promoting vascular inflammation and remodeling.
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