Intra-operative diagnosis of cerebral infarction by MEP (motor evoked potential)

Research Project

Project/Area Number	24592070
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Thoracic surgery
Research Institution	University of the Ryukyus
Principal Investigator	KUNIYOSHI Yukio 琉球大学, 医学(系)研究科(研究院), 教授 (50153317)
Co-Investigator(Kenkyū-buntansha)	KISE Yuya 琉球大学, 医学部附属病院, 助教 (00468076) NAGANO Takaaki 琉球大学, 医学部附属病院, 助教 (50363669) YAMASHIRO Satoshi 琉球大学, 医学(系)研究科(研究院), 准教授 (80315465) INAFUKU Hitoshi 琉球大学, 医学部附属病院, 講師 (30404578)
Project Period (FY)	2012-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	MEP / Hypothermia / cerebral infarction / 脳脊髄障害 / 体温 / 術中脳梗塞 / 頭蓋骨 / 刺激の方向 / Mapping
Outline of Final Research Achievements	The experimental study was carried out for rapid detection of newly developed cerebral infarction by MEP (motor evoked potential). It has been generally accepted that the early diagnosis and treatment of cerebral infarction makes better prognosis. To establish rapid diagnostic method for cerebral infarction during aortic arch surgery, MEP was evaluated for methodology of the purpose above. Result-1) MEP is definitely detected by setting cathode at mastoid process, and anode at submandibular soft tissue at the temperature range from 38 degrees C. to 20 degrees C.. Results-2) The latent time of MEP was measured 2.8 msec. on average, and was constant among whole range of body temperature. The experimental protocol above could be useful for studying the conduction system of cerebral-spinal nervous system, and also establishment of rapid diagnosis of intraoperative cerebral infarction in hypothermia.