The contribution mechanism of the periodontal disease to the pathological progression of atherosclerosis and aneurysmal enlargement

• Project/Area Number: 24592074
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Toho University
• Principal Investigator: SHIONO Noritsugu 東邦大学, 医学部, 准教授 (70235498)
• Co-Investigator(Kenkyū-buntansha): SEKIYA Hideki 東邦大学, 医学部, 准教授 (70267540) ; WATANABE Yoshinori 東邦大学, 医学部, 教授 (90210963) ; KATAYANAGI Tomoyuki 東邦大学, 医学部, 助教 (00385668)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 動脈硬化 / 歯周病 / 感染性心内膜炎 / サイトカイン

Outline of Final Research Achievements

As suggested by William Osler’s remark“a man is as old as his arteries,” pathological changes in arteries with age are thought to be closely related to effects on the body overall.
Hypothesizing that periodontal diseases contributes to the progression of arteriosclerotic lesion, we measured the severity of intraoral lesions and inflammatory cytokines (interleukin-6; IL-6, matrix metalloproteinase 9; MMP9) and investigated intraoperative arteriosclerotic findings for patients who underwent cardiovascular surgery. Correlations were confirmed between the maximum diameter of aortic aneurysms, inflammatory cytokines, and intraoral lesion index. These results were presented at the 2014 Meeting of the Asian Society for Cardiovascular and Thoracic Surgery (Istanbul). An investigation of bacterial strains in bacterial endocarditis suggested that the blood is exposed to intraoral bacteria at a high frequency. These were presented at the Clinical&Experimental Cardiology (Chicago).

Research Products

• [Journal Article] Frequency of detection of oral pathogenic bacteria in patients undergoing surgery for infectious endocarditis:Is blood exposed to oral bacteria on daily basis? (2013)
  • Author(s): Noritsugu Shiono, Takeshirou Fujii, Muneyasu Kawasaki, Shinnosuke Okuma, Yuuki Sasaki, Tomoyuki Katayanagi, Hiroshi Masuhara, Keiichi Tokuhiro, Tsukasa Ozawa, Akihisa Horie, Hideki Sekiya and Yoshinori Watanabe
  • Journal Title: J Clin Exp Cardiolog (an open access journal) Volume: 4 Issue: 07 Pages: 254-254
  • DOI: 10.4172/2155-9880.1000254
  • Peer Reviewed
• [Journal Article] Circulating blood is frequently exposed to periodontal bacteria (2013)
  • Author(s): Shiono N,Fujii T,Katayanagi T,Ozawa T,Kawasaki M,Horie A,Sekiya H,Watanabe Y
  • Journal Title: Jounal of Clinical & Experimental Cardiology Volume: 4 Issue: 01 Pages: 120-120
  • DOI: 10.4172/2155-9880.s1.016
• [Presentation] The rerationship between the severity of periodontal desease and the aortic aneurysm (2014)
  • Author(s): Katayanagi T, Shiono N, Fujii T, Nunoi Y, Sasaki Y, Okuma S, Sekiya H, Watabe Y
  • Organizer: 22nd Annual Meeting of The Asian Society for Cardiovascular & Thoracic Surgery
  • Place of Presentation: Istanbul, Turkey
  • Year and Date: 2014-04-04
• [Presentation] The reration ship between the severity of periodontal disease and the aortic aneurysm
  • Author(s): Katayanagi T, Shiono N, Fujii T, Nunoi Y, Sasaki Y, Okuma S, Sekiya H, Watanabe Y
  • Organizer: 22nd annual meeting of the asian society for cardiovascular and thoracic surgery
  • Place of Presentation: Istanbul/Turkey
• [Presentation] Detection of the periodontopathic bacteria in the blood and the cardiac tissue among surgical repair case of bacterial endocarditis
  • Author(s): Shiono N,Fujii T, Hara M, Katayanagi T, Ozawa T, Kawasaki M, Koyama N, Wtanabe Y
  • Organizer: The 20th Annual Meeting of The Asian Society for Cardiovascular&Thoracic Surgery
  • Place of Presentation: Bali, Indonesia
• [Presentation] 感染性心内膜炎手術症例における口腔内病変細菌の出現頻度
  • Author(s): 塩野則次、原真範、藤井毅郎、大熊新之介、佐々木雄毅、片柳智之、益原大志、小澤 司、川崎宗泰、横室浩樹、徳広圭一、小山信彌、堀江彰久、福井暁子、関谷秀樹、渡邉善則
  • Organizer: 第12回日本抗加齢医学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Presentation] Circulating blood is frequently exposed to periodontal bacteria
  • Author(s): Shiono N,Fujii T,Katayanagi T,Ozawa T,Kawasaki M,Horie A,Sekiya H,Watanabe Y
  • Organizer: 3rd International Conference on Clinical &Experimental Cardiology
  • Place of Presentation: Chicago, USA