Clinical studies on the mechanism of atrial fibrillation after cardiac survey
| Project/Area Number |
24592075
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Thoracic surgery
|
|---|
| Research Institution | Nihon University |
|---|
Principal Investigator |
SEZAI Akira 日本大学, 医学部, 講師 (70350006)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SHIONO Motomi 日本大学, 医学部, 教授 (20170847)
NAKATA Kinichi 日本大学, 医学部, 講師 (70328722)
YOSHITAKE Isamu 日本大学, 医学部, 助教 (60409034)
HIRAYAMA Atsushi 日本大学, 医学部, 教授 (50459880)
KASAMAKI Yuji 日本大学, 医学部, 准教授 (60318409)
NAKAI Toshiko 日本大学, 医学部, 准教授 (80366591)
|
|---|
| Project Period (FY) |
2012-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
|
|---|
| Keywords | 心房細動 / 心臓手術 |
|---|
| Outline of Final Research Achievements |
In this study, we studied various factors in addition to trying to identify a factor that would predict the potential for postoperative atrial fibrillation (POAF) prior to surgery in order to prevent its occurrence.
In this study, 180/753 patients (24%) developed POAF. Multivariate analysis confirmed that the risk factors were an age ≧75 years, CKD, emergency surgery, CPBT >180 min, intraoperative non-use of carperitide and landiolol, preoperative non-use of ARB and β-blockers, preoperative use of calcium antagonists and statins, and postoperative non-use of β-blockers. This study suggests that the preoperative values of serum ANP, angiotensin-II, KL-6, hyaluronic acid, and I-CTP iare useful as a new index for POAF. The fibrosis of tissue is believed to be closely related to POAF. Since preoperative, intraoperative and postoperative drug use is closely involved in the risk factor for POAF, it was considered possible that adequate perioperative drug therapy can prevent POAF.
|
Report
(5 results)
Research Products
(142 results)
-
[Journal Article] Carperitide and Atrial Fibrillation After Coronary Bypass Grafting: The Nihon University Working Group Study of Low-Dose HANP Infusion Therapy During Cardiac Surgery Trial for Postoperative Atrial Fibrillation2015
Author(s)
Sezai A, Iida M, Yoshitake I, Wakui S, Osaka S, Kimura H, Yaoita H, Hata H, Shiono M, Nakai T, Takayama T, Kunimoto S, Kasamaki Y, Hirayama A
-
Journal Title
Circulation: Arrhythmia and Electrophysiology
Volume: 8
Issue: 3
Pages: 546-553
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
[Journal Article] A Study on the Occurrence and Prevention of Perioperative Stroke after Coronary Artery Bypass Grafting2015
Author(s)
Sezai A, Nakata K, Iida M, Yoshitake I, Wakui S, Osaka S, Kimura H, Takahashi K, Ishii Y, Yaoita H, Arimoto M, Hata H, Shiono M, Takayama T, Hirayama A
-
Journal Title
Annals of Thoracic and Cardiovascular Surgery
Volume: 21
Issue: 3
Pages: 275-281
DOI
NAID
ISSN
1341-1098, 2186-1005
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 若手臨床医へのメッセージ2014
Author(s)
瀬在 明
Organizer
β遮断薬の真のパラダイムシフト講演会
Place of Presentation
JRホテルクレメント高松（香川県高松市）
Year and Date
2014-11-28
Related Report
Invited
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
