| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
This study investigated whether low frequency ventilation (LFV) would improve lung in-jury due to cardiopulmonary bypass (CPB) in patients who underwent cardiac surgeries. Patients in LFV group showed significantly higher PaO2 at 2 hours after CPB and PaC-O2 was significantly lower immediately after CPB. LFV group also showed significantly lower lactate leakage from the lungs after 2 hours from stopping CPB, which suggested that LFV would reduce ischemia-reperfusion injury during and after CPB. In analysis of cytokines in bronchial smear fluid, LFV group showed significantly lower IL-6 and IL-8 than control group and thus, suppression of inflammatory response by LFV was also indicated. Since ventilation time tended to be shorter in LFV group than in control group, it is supposed that LFV can provide clinical benefit to patients of cardiac sureries.
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