The evaluation of pleural invasion of lung cancer and pleural mesothelioma using narrow band imaging.

• Project/Area Number: 24592081
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: University of Tsukuba
• Principal Investigator: SATO Yukio 筑波大学, 医学医療系, 教授 (10312844)
• Co-Investigator(Kenkyū-buntansha): NOGUCHI Masayuki 筑波大学, 医学医療系, 教授 (00198582) ; GOTO Yukinobu 筑波大学, 医学医療系, 講師 (20451700) ; SAKAI Mitsuaki 筑波大学, 医学医療系, 研究員 (60375508)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 肺癌 / 血管新生 / 浸潤 / 胸膜 / 微小血管 / 胸膜浸潤

Outline of Final Research Achievements

The findings of pleural microvessels were evaluated in lung cancer and pleural mesothelioma patients using narrow band imaging (NBI). NBI enables precise imaging of microvessels and the findings were compared with histological findings. It was revealed that the appearance of irregular microvessels of the pleura on the surface of tumor was related to tumor invasion to pleura. These findings are considered to be helpful to elucidate the mechanism to tumor invasion with angiogenesis.

Research Products

• [Journal Article] Focusing on delayed clearance for identifying small-sized metastatic lung tumors using synchrotron radiation angiography with a highly sensitive receiver. (2014)
  • Author(s): Ito Hiromichi、Matsusita Shonosuke、Hyodo Kazuyuki、Tsurushima Hideo、Sato Yukio、Sakaibara Yuzuru
  • Journal Title: Gen Thorac Cardiovasc Surg. Volume: 62 Issue: 9 Pages: 553-559
  • DOI: 10.1007/s11748-014-0430-x
  • Peer Reviewed
• [Journal Article] High-dose concurrent chemo-proton therapy for Stage III NSCLC: preliminary results of a Phase II study (2014)
  • Author(s): Y Oshiro, T Okumura, K kurishima, S Honma, M Mizumoto, H Ishikawa, M Onizuka, M Sakai, Y Goto, N Hizawa, Y Sato, H Sakurai
  • Journal Title: J Radiat Res Volume: 55 Issue: 5 Pages: 959-965
  • DOI: 10.1093/jrr/rru034
  • Peer Reviewed / Open Access
• [Journal Article] Video-assisted thoracoscopic conservative repair of postoperative lobar torsion (2014)
  • Author(s): Sakai M, Kurimori K, Saeki Y, Kitazawa S, Kobayashi K, Iguchi K, Sato Y.
  • Journal Title: Ann Thorac Surg Volume: 98 Issue: 5 Pages: 119-21
  • DOI: 10.1016/j.athoracsur.2014.07.080
  • Peer Reviewed
• [Journal Article] 低電圧凝固（ソフト凝固）－バイボーラとモノボーラ (2014)
  • Author(s): 佐藤幸夫
  • Journal Title: 胸部外科 Volume: 67 Pages: 732-736
  • Peer Reviewed
• [Presentation] 当科における術前３D画像併用CompleteVATSsegmentectomy (2014)
  • Author(s): 後藤行延、佐伯祐典、北沢伸祐、小林敬祐、山本純、井口けさ人、菊池慎二、鈴木久史、酒井光昭、鬼塚正孝,佐藤幸夫
  • Organizer: 第55回日本肺癌学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2014-11-14 – 2014-11-16
• [Presentation] 胸腔鏡下右肺癌手術 分岐下郭清の工夫 (2014)
  • Author(s): 佐藤幸夫
  • Organizer: 第67回日本胸部外科学会定期学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2014-09-30 – 2014-10-03
• [Presentation] 右肺癌に対する原発肺葉との連続性を保った胸腔鏡下リンパ節郭清 (2014)
  • Author(s): 佐藤 幸夫、佐伯 祐典、北沢 伸祐、小林 敬祐、山本 純、菊池 慎二、井口 けさ人、鈴木 久史、後藤 行延、酒井 光昭
  • Organizer: 第31回日本呼吸器外科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-28 – 2014-05-30
• [Presentation] 右上葉SSTに術前導入化学放射線治療後、TMA+胸腔鏡アプローチにて右鎖骨下動脈合併切除を施行した一例 (2014)
  • Author(s): 佐藤 幸夫、柳原 隆宏、中岡 浩二郎、佐伯 祐典、山岡 賢俊、山本 純、菊池 慎二、後藤 行延、酒井 光昭
  • Organizer: 第55回日本肺癌学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2014-05-14 – 2014-05-16