Balance between memory T cell and regulatory T cell in lung transplant recipients

• Project/Area Number: 24592088
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Kyoto University
• Principal Investigator: AOYAMA Akihiro 京都大学, 医学(系)研究科(研究院), 助教 (60379047)
• Co-Investigator(Kenkyū-buntansha): DATE Hiroshi 京都大学, 大学院医学研究科, 教授 (60252962) ; BANDO Toru 京都大学, 大学院医学研究科, 准教授 (20293954) ; CHIN Toyofumi 京都大学, 大学院医学研究科, 助教 (00452334) ; SATO Masaaki 京都大学, 大学院医学研究科, 助教 (00623109)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 肺移植 / 拒絶 / モニター / 生体移植 / 脳死移植 / メモリー細胞 / 免疫抑制 / 細胞性免疫能

Outline of Final Research Achievements

From 2012 through 2014, 26 living donor lobar lung transplantations and 33 deceased donor lung transplantations were performed at our institution. As of June 2015, 51 recipients are alive. The causes of deaths of 8 recipients include infection in 4, PTLD in two, and early or chronic graft dysfunction in 2. Thirty-four recipients (58%) were successfully treated with one or more courses of steroid pulse under the diagnosis of possible acute rejection. No recipient developed bronchiolitis obliterans syndrome (BOS), which is the very object of the present study. We will continue to follow up recipinets, using spirometry, CT scan or ventilation scintigraphy, and will analyze lymphocytes obtained from BOS recipients in view of surface markers, expression of FoxP3, and ELISPOT in future.

Research Products

• [Journal Article] Incidence and pattern of hemolytic anemia after minor ABO-mismatch living-donor lobar lung transplantation. (2013)
  • Author(s): Ohsumi A, Chen F, Yurugi K, Maekawa T, Shoji T, Sato M, Aoyama A, Bando T, Date H
  • Journal Title: Surg Today Volume: 43 Pages: 1250-3
  • NAID: 120005526704
  • Peer Reviewed
• [Journal Article] Adaptation over a wide range of donor graft lung size discrepancies in living-donor lobar lung transplantation. (2013)
  • Author(s): Chen F, Kubo T, Yamada T, sato M, Aoyama A, Bando T, Date H.
  • Journal Title: Am J Transplan Volume: 13 Pages: 1336-42
  • Peer Reviewed
• [Journal Article] Protective effect of plasma in marginal donor lungs in an ex vivo lung perfusion model. (2013)
  • Author(s): Motoyama H, Chen F, Ohsumi A, Hijiya K, Okita K, Nakajima D, Sakamoto J, Yamada T, Sato M, Aoyama A, bando T, Date H.
  • Journal Title: J Heart Lung Transplant Volume: 32 Pages: 505-10
  • Peer Reviewed
• [Journal Article] Postoperative respiratory management in living-donor lobar lung transplantation. (2013)
  • Author(s): 318. Chen F, Chin K, Sato M, Aoyama A, Murase k, Azuma M, Bando T, Date H.
  • Journal Title: Clin Transplant Volume: 27
  • Peer Reviewed
• [Journal Article] A prospective study analyzing one-year multidimensional outcomes in living lung transplant donors. (2013)
  • Author(s): 324. Chen F, Oga T, Sakai H, Matsumoto I, Yamada T, Sato M, Aoyama A, Bnado T, Mishima M, Chin K, Date H.
  • Journal Title: Am J Transplant Volume: 13 Pages: 3003-9
  • Peer Reviewed
• [Presentation] 京都大学における肺高血圧症に対する肺移植例
  • Author(s): 青山 晃博、伊達 洋至
  • Organizer: 第1回日本肺高血圧学会学術集会
  • Place of Presentation: 横浜