Ex-vivo lung evaluation/reconditioning for marginal lungs from brain-dead donor

• Project/Area Number: 24592091
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Okayama University
• Principal Investigator: OTO TAKAHIRO 岡山大学, 医歯(薬)学総合研究科, 准教授 (40452578)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 肺移植 / 体外臓器リカバリシステム / 体外臓器リカバリーシステム / Exvivo lung perfusion / 日本

Outline of Final Research Achievements

Donor shortage remains a significant limiting factor of lung transplantation in Japan. We have successfully introduced clinical ex-vivo lung evaluation/reconditioning for patients with end-stage pulmonary diseases. This was the first success in Asia.

Research Products

• [Journal Article] Utilization of extended criteria lungs on a lobe-by-lobe basis through ex vivo lung perfusion assessment (2015)
  • Author(s): K. Miyoshi, T. Oto, Y. Konishi, Y. Hirano, M. Okada, N. Iga, S. Hirayama, S. Sugimoto, M. Yamane, S. Miyoshi.
  • Journal Title: Ann Thorac Surg 2015 Volume: in press
  • Peer Reviewed
• [Journal Article] Basal segmental auto-transplantation after pneumonectomy for advanced central lung cancer (2012)
  • Author(s): Oto T, Kiura K, Toyooka S, Miyoshi S.
  • Journal Title: Eur J Cardiothorac Surg. Volume: 42(3):. Issue: 3 Pages: 579-81
  • DOI: 10.1093/ejcts/ezs224
  • Peer Reviewed
• [Presentation] Pediatric lung transplantation:principle and surgical tips (2015)
  • Author(s): Takahiro Oto
  • Organizer: Asian Association for Cardiovasucular and Thoracic Surgery
  • Place of Presentation: Hong Kong、China
  • Year and Date: 2015-05-12
• [Presentation] Can donor scores remove bias in donor selection? (2015)
  • Author(s): Takahiro Oto
  • Organizer: International Society for Hear and Lung Transplantation
  • Place of Presentation: Nice, France
  • Year and Date: 2015-04-15 – 2015-04-18
  • Invited
• [Presentation] Ex-vivo Lung Perfusionの臨床導入によるマージナル肺移植 (2015)
  • Author(s): 三好健太郎，大藤剛宏
  • Organizer: 第31回日本肺および心肺移植研究会
  • Place of Presentation: Tokyo
  • Year and Date: 2015-01-31
• [Presentation] Ex-vivo Lung Perfusion臨床導入によるマージナル肺移植の実際 (2014)
  • Author(s): 三好健太郎，大藤剛宏
  • Organizer: 第31回日本呼吸器外科学会総会
  • Place of Presentation: Tokyo
  • Year and Date: 2014-05-29 – 2014-05-30
• [Presentation] Utilization of extended criteria lung on a lobe-by-lobe basis through ex-vivo lung perfusion reassessment (2014)
  • Author(s): K. Miyoshi, T. Oto
  • Organizer: The International Society for Heart and Lung Transplantation 34th Annual meeting and Scientific Sessions
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-04-07 – 2014-04-09
• [Presentation] Exvivo lung reperfusion
  • Author(s): 三好健太郎 大藤剛宏
  • Organizer: ISHLT 2014
  • Place of Presentation: SanDiego