| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
Lung cancer is one of the leading causes of cancer deaths in the world. The cancer cells have a genetically dynamic state (genetic instability), which is believed to produce the resistant cells. Chromosomal instability (CIN) may be involved in this mechanism. In this study, we examine the significance of CIN in lung cancer, and examined the factors involved in CIN. In the lung cancer cells showing CIN, the high expression of a DNA damage repair-related factor, Chk2 gene. The prognosis of lung cancer with high Chk2 expression is worse than that with low Chk2 expression. It has been suggested that Chk2 is involved in the development of lung cancer
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