Chromosomal instability in lung cancer and innovative strategy for avoiding therapeutic resistance
Project/Area Number |
24592095
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Thoracic surgery
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Research Institution | Kyushu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
HARO Akira 九州大学, 大学病院, 助教 (90546558)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 染色体不安定性 / 非小細胞肺癌 / DNA損傷修復 / 肺癌遺伝子異常 |
Outline of Final Research Achievements |
Lung cancer is one of the leading causes of cancer deaths in the world. The cancer cells have a genetically dynamic state (genetic instability), which is believed to produce the resistant cells. Chromosomal instability (CIN) may be involved in this mechanism. In this study, we examine the significance of CIN in lung cancer, and examined the factors involved in CIN. In the lung cancer cells showing CIN, the high expression of a DNA damage repair-related factor, Chk2 gene. The prognosis of lung cancer with high Chk2 expression is worse than that with low Chk2 expression. It has been suggested that Chk2 is involved in the development of lung cancer
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Prognostic and therapeutic implications of aromatase expression in lung adenocarcinomas with EGFR mutations.2014
Author(s)
Kohno M, Okamoto T, Suda K, Shimokawa M, Kitahara H, Shimamatsu S, Konishi H, Yoshida T, Takenoyama M, Yano T, Maehara Y.
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Journal Title
Clinical Cancer Research
Volume: 20
Issue: 13
Pages: 3613-22
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Prognostic impact of EGFR driver mutations on postoperative recurrence in non-small cell lung cancer2014
Author(s)
Tatsuro Okamoto, Hirokazu Kitahara, Shinichiro Shimamatsu, Masakazu Katsura, Kazutoshi Takada, Takatoshi Fujishita, Yuzo Suzuki, Yosuke Morodomi, Tetsuzo Tagawa and Yoshihiko Maehara
Organizer
9th INTERNATIONAL CONFERENCE OF ANTICANCER RESEARCH
Place of Presentation
Porto Carras, Sithonia, Greece
Year and Date
2014-10-06 – 2014-10-10
Related Report
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[Presentation] Chromosomal instability and DNA damage response pathway in lung adenocarcinoma2012
Author(s)
Tatsuro Okamoto, Hiroyuki Kitao, Hirokazu Kitahara, Shinichiro Shimamatsu, Mikihiro Kohno, Tsukihisa Yosida, Kenichi Suda, Hiroshi Saeki, Eriko Tokunaga, Eiji Oki, and Yoshihiko Maehara
Organizer
5th Asia Pacific Lung Cancer Conference (APLCC)
Place of Presentation
Fukuoka, Japan
Related Report