| Project/Area Number |
24592096
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Thoracic surgery
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
IKEDA KOEI 熊本大学, 医学部附属病院, 助教 (20448525)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Makoto 熊本大学, 大学院生命科学研究部, 教授 (80312940)
SHIRAISHI Kenji 熊本大学, 大学院生命科学研究部, 助教 (70363538)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
|
|---|
| Keywords | 多発肺腺癌 / メチル化 / アロマターゼ / エストロゲン / CYP19A1 / LINE-1 / 肺腺癌 / EGFR / メチル化異常 |
|---|
| Outline of Final Research Achievements |
A minor allele of SNP rs3764221, which is located in the CYP19A1 gene, was significantly associated with multiple adenocarcinomas risk. Other analyzed polymorphisms and LINE-1 methylation level of normal lung tissue were not significantly associated with the risk of multiple adenocarcinomas.
Conclusions: A minor allele of SNP rs3764221, which is located in the CYP19A1 gene, was significantly associated with multiple adenocarcinomas risk. Other polymorphisms and LINE-1 methylation levels of background lung were not significantly associated with the risk of multiple adenocarcinomas.
|
