Genetic backgrounds associated with multicentric developmant of lung adenocarcinoma

• Project/Area Number: 24592096
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Kumamoto University
• Principal Investigator: IKEDA KOEI 熊本大学, 医学部附属病院, 助教 (20448525)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Makoto 熊本大学, 大学院生命科学研究部, 教授 (80312940) ; SHIRAISHI Kenji 熊本大学, 大学院生命科学研究部, 助教 (70363538)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
• Keywords: 多発肺腺癌 / メチル化 / アロマターゼ / エストロゲン / CYP19A1 / LINE-1 / 肺腺癌 / EGFR / メチル化異常

Outline of Final Research Achievements

A minor allele of SNP rs3764221, which is located in the CYP19A1 gene, was significantly associated with multiple adenocarcinomas risk. Other analyzed polymorphisms and LINE-1 methylation level of normal lung tissue were not significantly associated with the risk of multiple adenocarcinomas.
Conclusions: A minor allele of SNP rs3764221, which is located in the CYP19A1 gene, was significantly associated with multiple adenocarcinomas risk. Other polymorphisms and LINE-1 methylation levels of background lung were not significantly associated with the risk of multiple adenocarcinomas.

Research Products

• [Journal Article] Association of a Genetic Variant of CYP19A1 with Multicentric Development of Lung Adenocarcinomas. (2014)
  • Author(s): Ikeda K, Shiraishi K, Eguchi A, Osumi H, Matsuishi K, Matsubara E, Fujino K,Shibata H, Yoshimoto K, Mori T, Omori H, Suzuki M.
  • Journal Title: Ann Surg Oncol. Volume: 21 Issue: 3 Pages: 939-945
  • DOI: 10.1245/s10434-013-3362-2
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Long interspersed nucleotide element 1 hypomethylation is associated with poor prognosis of lung adenocarcinoma. (2013)
  • Author(s): Ikeda K, Shiraishi K, Eguchi A, et al.
  • Journal Title: Ann Thorac Surg. Volume: 96 Issue: 5 Pages: 1790-1794
  • DOI: 10.1016/j.athoracsur.2013.06.035
  • Peer Reviewed
• [Journal Article] Aberrant methylation of LINE-1, SLIT2, MAL, and IGFBP7 in non-small cell lung cancer (2013)
  • Author(s): Suzuki M, Shiraishi K, Eguchi A, Ikeda K, Mori T, Yoshimoto K, Ohba Y, Ito Yamada T, Ito T, Baba Y, Baba H
  • Journal Title: Oncol Rep Volume: 29(4) Issue: 4 Pages: 1308-14
  • DOI: 10.3892/or.2013.2266
  • Peer Reviewed
• [Presentation] 多発肺腺癌の遺伝的背景の検討 (2013)
  • Author(s): 池田公英
  • Organizer: 第113回日本外科学会定期学術集会
  • Place of Presentation: 福岡市マリンメッセ福岡
• [Presentation] 非小細胞肺癌におけるLINE-1のメチル化異常と臨床病理学的特徴、生命予後との関連性 (2013)
  • Author(s): 池田公英
  • Organizer: 第30回日本呼吸器外科学会
  • Place of Presentation: 名古屋市名古屋国際会議場
• [Presentation] 肺腺癌の発生とCYP19A1遺伝子多型の関連性 (2013)
  • Author(s): 池田公英
  • Organizer: 第54回日本肺癌学会総会
  • Place of Presentation: 東京都ホテルニューオータニ
• [Presentation] 非小細胞肺癌におけるLINE-1のDNAメチル化異常と臨床病理学的特徴、生命予後との関連性 (2013)
  • Author(s): 池田公英
  • Organizer: 第30回日本呼吸器外科学会
  • Place of Presentation: 名古屋市名古屋国際会議場