Prediction of postoperative prognoses by gene expression profiling in patients with primary resected lung cancer
| Project/Area Number |
24592098
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Toho University (2013-2014)
Kitasato University (2012) |
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Principal Investigator |
IYODA Akira 東邦大学, 医学部, 教授 (10302548)
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Yukitoshi 北里大学, 医学部, 教授 (90321637)
HATA Yoshinobu 東邦大学, 医学部, 准教授 (90349910)
TAMAKI Kazuyoshi 東邦大学, 医学部, 助教 (80385799)
SATO Fumitomo 東邦大学, 医学部, 助教 (30385736)
OTSUKA Hajime 東邦大学, 医学部, 助教 (70408855)
MAKINO Takashi 東邦大学, 医学部, 助教 (30459797)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 肺癌 / 個別化 / 予後 / システムの構築 |
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| Outline of Final Research Achievements |
We analyzed LCNEC gene expression, gene mutation and immunohistochemical expression of known molecular targets and compared expression to that of lung adenocarcinomas. We analyzed 26 patients with primary LCNEC and 40 patients with adenocarcinoma (AC). We evaluated immunohistochemical (IHC) expression for topoisomerase I, II (TOPO1, 2), excision repair cross-complementing gene 1 (ERCC1), class III beta tubulin (TUBB3) and EGFR mutation (L858R) and gene mutation for EGFR using direct DNA sequencing and Scorpion-ARMS. There was a significant difference in IHC expression for TOPO2 and EGFR between LCNEC and AC. EGFR gene mutation was greater in the AC group, with no EGFR mutation in the LCNEC group. On the IHC expression of TOPO1, ERCC1, and TUBB3, there were no significant differences between LCNEC and AC.
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Report
(4 results)
Research Products
(11 results)
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[Presentation] 肺大細胞神経内分泌癌手術例の臨床病理学的検討2015
Author(s)
牧野崇, 秦美暢, 大塚創, 佐藤史朋, 肥塚智, 田巻一義, 笹本修一, 磯部和順, 栃木直文, 渋谷和俊, 伊豫田明
Organizer
第114回日本外科学会定期学術集会
Place of Presentation
国立京都国際会館（京都府京都市）
Year and Date
2015-04-04
Related Report
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[Presentation] 肺高悪性度神経内分泌癌の術後再発の検討2014
Author(s)
牧野崇, 秦美暢, 佐藤史朋, 大塚創, 肥塚智, 田巻一義, 笹本修一, 磯部和順, 栃木直文, 渋谷和俊, 伊豫田明
Organizer
第31回日本呼吸器外科学会総会
Place of Presentation
ホテル日航東京（東京都港区）
Year and Date
2014-05-29
Related Report
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[Presentation] Bronchopulmonary carcinoids
Author(s)
Akira Iyoda, Satoshi Koezuka, Takashi Makino, Hajime Otsuka, Fumitomo Sato, Kazuyoshi Tamaki, Yoshinobu Hata, Naobumi Tochigi, Kazutoshi Shibuya, Tetuo Mikami, Kazutoshi Isobe, Sakae Homma
Organizer
15th World Conference on Lung Cancer
Place of Presentation
オーストラリア・シドニー
Related Report
Invited
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