| Project/Area Number |
24592107
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Fumihiro 産業医科大学, 医学部, 教授 (10283673)
SHIGEMATSU Yoshiki 産業医科大学, 医学部, 非常勤医師 (10546469)
HANAGIRI Takeshi 産業医科大学, 医学部, 非常勤医師 (30299614)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 悪性胸膜中皮腫 / バイオマーカー / THBS2 / 上皮間葉転換 / MPM / EMT / biomarker / serum / aaa / γ-catenin / Twist / THBS-2 / Sera / ELISA method |
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| Outline of Final Research Achievements |
Malignant pleural mesothelioma (MPM) is a poor prognosis disease caused by asbestos exposure, and is expected to increase in the future. In this study, we intended the early detection of MPM and the elucidation of the pathology for the search of better treatment method. We reviewed the usefulness of Gene X and THBS2 as a diagnostic marker in MPM. THBS2 was useful marker for early diagnosis, but correlation with prognosis was not observed. In addition, we examined the epithelial-mesenchymal transition (EMT) related markers in MPM. Although each marker may not contribute to the progression of MPM, γ-catenin expression-negative and twist expression-positive patients have poor prognosis.
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