• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Development of high sensitivity detection method of CTCs in lung cancer using microfluidic chip system

Research Project

Project/Area Number 24592108
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Thoracic surgery
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

OKA Soichi  産業医科大学, 医学部, 助教 (20596655)

Co-Investigator(Kenkyū-buntansha) TANAKA Fumihiro  産業医科大学, 医学部, 教授 (10283673)
URAMOTO Hidetaka  産業医科大学, 医学部, 准教授 (90389445)
SO Tomoko  産業医科大学, 医学部, 講師 (00331529)
ONAGA Takashi  富山工業技術センター中央研究所, 主幹研究員 (10416133)
宗 知子  産業医科大学, 医学部, 講師 (00341529)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords肺癌 / バイオマーカー / 循環腫瘍細胞 / 循環腫瘍細胞(CTC) / CTC-chip / 上皮接着分子(EpCAM) / 循環腫瘍細胞(CTC) / CellSearch / 循環血液中腫瘍細胞 / lung cancer
Outline of Final Research Achievements

Prognosis of primary lung cancer patients is not satisfactory, which is mostly caused by frequent development of distant metastasis. Although Circulating Tumor Cell (CTC) is useful for a surrogate marker of distant micro-metastasis, the CellSearch which is the only machine for CTC detection for clinical use, is insufficient sensitivity. Therefore, we developed a new microfluidic chip system of domestic, to improve sensitivity, and evaluated its basic performance. Newly developed CTC-chip not only EpCAM that have been targeted up to now showed good capture ability for other cell surface antigens. In addition, it was possible genetic analysis of the captured cells.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (9 results)

All 2014 2013 2012

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (5 results)

  • [Journal Article] Clinical Significance of IGF1R Expression in Non-Small-Cell Lung Cancer2012

    • Author(s)
      Nakagawa M, Uramoto H, Oka S (9人中3番目)
    • Journal Title

      Clin Lung Cancer

      Volume: 2 Pages: 136-142

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Expression of CD146 Predicts a Poor Overall Survival in Patients with Adenocarcinoma of the Lung2012

    • Author(s)
      Oka S, Uramoto H, Chikaishi Y, Tanaka F
    • Journal Title

      Anticancer Res

      Volume: 32 Pages: 861-4

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic implications of human leukocyte antigen class I expression inpatients who underwent surgical resection for non-small-cell lung cancer.2012

    • Author(s)
      Hanagiri T, Oka S (12人中10番目)
    • Journal Title

      J Surg Res

      Volume: nil

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical Significance of IGF1R Expression in Non-Small-Cell Lung Cancer2012

    • Author(s)
      Nakagawa M, Uramoto H, Oka S, Chikaishi Y, Iwanami T, Shimokawa H, So T, Hanagiri T, Tanaka F
    • Journal Title

      Clin Lung Cancer

      Volume: 13 Issue: 2 Pages: 136-142

    • DOI

      10.1016/j.cllc.2011.10.006

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Comparison of CellSearch with polymeric microfluidic devices for CTC isolation using EpCAM-negative tumor cell lines of malignant pleural mesothelioma2014

    • Author(s)
      Yasuhiro Chikaishi1), Tomoko So1), Masaru Takenaka1), Soichi Oka1), Ayako Hirai1), Takashi Iwanami1), Kazue Yoneda1), Hidehiko Shimokawa1), Yoshika Nagata1), Hidetaka Uramoto1), Takeshi Ohnaga2), and Fumihiro Tanaka1)
    • Organizer
      AACR meeting
    • Place of Presentation
      San Diego CA(USA)
    • Year and Date
      2014-04-05 – 2014-04-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of system to detect circulating tumor cell in malignant pleural mesothelioma2013

    • Author(s)
      Yasuhiro Chikaishi, Tomoko So, Masaru Takenaka, Soichi Oka, Makoto Nakagawa, Hidehiko Shimokawa, Teruo Iwata, Hidetaka Uramoto, Takeshi Hanagiri, Fumihiro Tanaka, Takeshi Ohnaga
    • Organizer
      AACR meeting
    • Place of Presentation
      Washington,USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 循環腫瘍細胞(CTC)の検出方法の開発2013

    • Author(s)
      近石泰弘、宗 知子、米田和恵、浦本秀隆、花桐武志
    • Organizer
      BioJapan2013
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Research-status Report
  • [Presentation] Development of detecting systems for circulating tumor cells in malignant pleural mesothelioma patients2013

    • Author(s)
      Oka S, Chikaishi Y
    • Organizer
      第46回米国癌学会(American Association for Cancer Research, AACR)年次総会
    • Place of Presentation
      Mc Cormick Place(米国・シカゴ)
    • Related Report
      2012 Research-status Report
  • [Presentation] Circulating tumor cell (CTC) as a significant clinical marker in epithelioid-type malignant pleural mesothelioma2012

    • Author(s)
      Yoneda K, Tanaka F, Chikaishi, Oka S
    • Organizer
      第48回米国癌治療学会(American Society of Clinical Oncology, ASCO)年次総会
    • Place of Presentation
      Cormick Place(米国・シカゴ)
    • Related Report
      2012 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi