Detection of Lung Cancer Cells Using Activatable Fluorescent Probe

• Project/Area Number: 24592109
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Thoracic surgery
• Research Institution: Japanese Foundation for Cancer Research
• Principal Investigator: SAKAO Yukinori 公益財団法人がん研究会, その他部局等, 研究員 (00274605)
• Co-Investigator(Kenkyū-buntansha): MUN Mingyon 公益財団法人がん研究会, その他部局等, その他 (10574642) ; OKUMURA Sakae 公益財団法人がん研究会, その他部局等, その他 (40465935)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: イメージング / 有機プローブ / 肺がん

Outline of Final Research Achievements

Activatable fluorescent probe is a cell surface-associated enzyme that is overexpressed in various types of human cancers. In this study, 112 resected lung cancers (91 primary lung cancers and 21 metastatic lung cancers) and 4 pleural disseminated nodules were prospectively included. Of the primary lung cancers, 67% rapidly showed positive fluorescent activity. Positive fluorescent activity rates of the metastatic lung cancers and pleural disseminations were 71% and 100%, respectively.
We believe activatable fluorescent probe could aid surgeons in detecting tiny cancer during operation.