| Project/Area Number |
24592110
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Hokkaido University |
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Principal Investigator |
ABUMIYA Takeo 北海道大学, 医学(系)研究科(研究院), 特任助教 (80270726)
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| Co-Investigator(Kenkyū-buntansha) |
HOUKIN Kiyohiro 北海道大学, 大学院医学研究科, 教授 (90229146)
NAKAYAMA Naoki 北海道大学, 大学院医学研究科, 講師 (40421961)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 脳梗塞 / 虚血再灌流 / 脳低温治療 / ｊ虚血再灌流 / 低脳温治療 |
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| Outline of Final Research Achievements |
The present study initially confirmed that trans-arterial regional hypothermia possessed strong neuroprotective effects on ischemia-reperfusion (I/R) injury, and then demonstrated that the treatment sequentially inhibited the acute aquapolin4 (AQP4) surge, microvascular narrowing due to astrocytic end-foot swelling, endothelial dysfunction, and activation of inflammatory reactions. More direct and intensive cooling of the endothelium and its surroundings, including astrocytic end-feet, may contribute to these therapeutic effects. This therapeutic strategy is convenient and feasible for clinical applications by an endovascular approach; therefore, it represents a promising candidate to attenuate I/R injury after tissue plasminogen activator thrombolysis and/or endovascular thrombectomy.
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