Development of regional brain hypothremia by trans-ventricular and trans-arterial cold infusion in acute cerebral ischemia
Project/Area Number |
24592110
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cerebral neurosurgery
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Research Institution | Hokkaido University |
Principal Investigator |
ABUMIYA Takeo 北海道大学, 医学(系)研究科(研究院), 特任助教 (80270726)
|
Co-Investigator(Kenkyū-buntansha) |
HOUKIN Kiyohiro 北海道大学, 大学院医学研究科, 教授 (90229146)
NAKAYAMA Naoki 北海道大学, 大学院医学研究科, 講師 (40421961)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | 脳梗塞 / 虚血再灌流 / 脳低温治療 / j虚血再灌流 / 低脳温治療 |
Outline of Final Research Achievements |
The present study initially confirmed that trans-arterial regional hypothermia possessed strong neuroprotective effects on ischemia-reperfusion (I/R) injury, and then demonstrated that the treatment sequentially inhibited the acute aquapolin4 (AQP4) surge, microvascular narrowing due to astrocytic end-foot swelling, endothelial dysfunction, and activation of inflammatory reactions. More direct and intensive cooling of the endothelium and its surroundings, including astrocytic end-feet, may contribute to these therapeutic effects. This therapeutic strategy is convenient and feasible for clinical applications by an endovascular approach; therefore, it represents a promising candidate to attenuate I/R injury after tissue plasminogen activator thrombolysis and/or endovascular thrombectomy.
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Report
(4 results)
Research Products
(6 results)
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[Presentation] Post-ischemic trans-arterial regional hypothermia therapy attenuates microvascular narrowing due to astrocyte end-feet swelling and inhibits subsequent inflammatory reactions in ischemia reperfusion injury2015
Author(s)
Kota Kurisu, Takeo Abumiya, Hideki Nakamura, Daisuke Shimbo, Ken Kazumata, Naoki Nakayama, Hideo Shichinohe, Masaaki Hokari, Toshiya Osanai, Hiroshi Shimizu, Kiyohiro Houkin
Organizer
International stroke conference 2015
Place of Presentation
Nashville, USA
Year and Date
2015-02-11 – 2015-02-13
Related Report
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