Non-invasive cerebral blood flow and metabolism analysis using by high field magnetic resonance imaging

• Project/Area Number: 24592112
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Tohoku University
• Principal Investigator: INOUE Takashi 東北大学, 医学(系)研究科(研究院), 非常勤講師 (70326651)
• Co-Investigator(Kenkyū-buntansha): TOMINAGA Teiji 東北大学, 大学院医学系研究科, 教授 (00217548)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: MRI / 脳循環代謝 / 非侵襲 / 脳卒中 / 脳血管障害 / 転帰予測 / CBF / SPECT / 定量

Outline of Final Research Achievements

Non-invasive estimation for cerebral blood flow and metabolism using by high field MR imaging was newly developed. Only invasive methods have been sullied for cerebral blood flow and metabolism analysis. We accepted the flow-sensitive attenuated inversion recovery method for estimation to measure cerebral blood flow in patients with stroke. MR spectroscopy was applied for clinical examination to measure brain temperature of patients with stroke. We clarified the utility and limitation for clinical usage of MRI to investigate cerebral blood flow and metabolism.

Research Products

• [Journal Article] Angiographic circulation time and cerebral blood flow during balloon test occlusion of the internal carotid artery. (2014)
  • Author(s): Sato K, Shimizu H, Inoue T, Fujimura M, Matsumoto Y, Kondo R, Endo H, Sonoda Y, Tominaga T.
  • Journal Title: J Cereb Blood Flow Metab Volume: 34 Issue: 1 Pages: 136-143
  • DOI: 10.1038/jcbfm.2013.176
  • Peer Reviewed
• [Journal Article] Maximum preservation of the media in carotid endarterectomy. (2014)
  • Author(s): Niizuma K, Shimizu H, Inoue T, Watanabe M, Tominaga T
  • Journal Title: Neurol Med Chir Volume: 54 Pages: 812-818
  • NAID: 130004690988
  • Peer Reviewed
• [Journal Article] Cognard type V intracranial dural arteriovenous shunt: case reports and literature review with special consideration of the pattern of spinal venous drainage. (2014)
  • Author(s): Haryu S, Endo T, Sato K, Inoue T, Takahashi A, Tominaga T
  • Journal Title: Neurosurgery Volume: 74 Issue: 1 Pages: 135-142
  • DOI: 10.1227/neu.0000000000000069
  • Peer Reviewed
• [Journal Article] A Case of Bilateral Giant Internal Carotid Artery Aneurysms at the Cavernous Portion Managed by 2-stage Extracranial-Intracranial Bypass with Parent Artery Occlusion: Consideration for Bypass Selection and Timing of Surgeries. (2014)
  • Author(s): Fujimura M, Sato K, Kimura N, Inoue T, Shimizu H, Tominaga T.
  • Journal Title: Journal of stroke and cerebrovascular diseases Volume: 23 Issue: 8 Pages: 393-398
  • DOI: 10.1016/j.jstrokecerebrovasdis.2014.02.020
  • Peer Reviewed
• [Journal Article] Minocycline prevents focal neurological deterioration due to cerebral hyperperfusion after extracranial-intracranial bypass for moyamoya disease (2014)
  • Author(s): Fujimura M, Niizuma K, Inoue T, Sato K, Endo H, Shimizu H, T ominaga T
  • Journal Title: Neurosurgery Volume: 74(2) Issue: 2 Pages: 163-70
  • DOI: 10.1227/neu.0000000000000238
  • Peer Reviewed
• [Journal Article] Quantitative assessment of cerebral hemodynamics using single photon emission computed tomography with venous blood sampling. (2013)
  • Author(s): Inoue T, Fujimura M, Shimizu H, Takahashi Y, Tominaga T.
  • Journal Title: Clin Neurol Neurosurg. Volume: 115 Issue: 6 Pages: 684-689
  • DOI: 10.1016/j.clineuro.2012.08.020
  • Peer Reviewed
• [Journal Article] Noninvasive measurement of human brain temperature adjacent to arteriovenous malformation using 3.0 T magnetic resonance spectroscopy (2013)
  • Author(s): Inoue T., Shimizu H., Fujimura M., Saito A., Yoshioka Y., Matsuda T., Tominaga T.
  • Journal Title: Clinical Neurology and Neurosurgery Volume: 115 Issue: 4 Pages: 445-449
  • DOI: 10.1016/j.clineuro.2012.06.022
  • Peer Reviewed
• [Journal Article] Signal change on T2*-weighted magnetic resonance imaging from the acute to chronic phases in patients with subarachnoid hemorrhage. (2013)
  • Author(s): Inoue T, Takada S, Shimizu H, Niizuma K, Fujimura M, Sato K, Endo H, Tominaga T
  • Journal Title: Cerebrovasc Dis. Volume: 36 Issue: 5-6 Pages: 421-429
  • DOI: 10.1159/000355897
  • Peer Reviewed
• [Journal Article] Ruptured aneurysm of a posterior inferior cerebellar artery communicating artery. Case report and histological findings (2012)
  • Author(s): Sugiyama, S., Fujimura, M., Inoue, T., Shimizu, H., Watanabe, M. and Tominaga, T.
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 52 Pages: 81-83
  • Peer Reviewed
• [Journal Article] Temporal profile of de novo development of moyamoya vasculopathy in an adult: case report (2012)
  • Author(s): Shimoda, Y., Fujimura, M., Inoue, T., Shimizu, H. and Tominaga, T.
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 52 Pages: 339-342
  • NAID: 10030314630
  • Peer Reviewed
• [Journal Article] Local hemodynamics at the rupture point of cerebral aneurysms determined by computational fluid dynamics analysis (2012)
  • Author(s): Omodaka, S., Sugiyama, S., Inoue, T., Funamoto, K., Fujimura, M., Shimizu, H., Hayase, T., Takahashi, A. and Tominaga, T.
  • Journal Title: Cerebrovasc Dis Volume: 34 Issue: 2 Pages: 121-129
  • DOI: 10.1159/000339678
  • Peer Reviewed
• [Journal Article] Influence of surface model extraction parameter on computational fluid dynamics modeling of cerebral aneurysms (2012)
  • Author(s): Omodaka, S., Inoue, T., Funamoto, K., Sugiyama, S., Shimizu, H., Hayase, T., Takahashi, A. and Tominaga, T.
  • Journal Title: J Biomech Volume: 45 Issue: 14 Pages: 2355-2361
  • DOI: 10.1016/j.jbiomech.2012.07.006
  • Peer Reviewed
• [Journal Article] Prediction of motor function outcome after intracerebral hemorrhage using fractional anisotropy calculated from diffusion tensor imaging (2012)
  • Author(s): Kuzu, Y., Inoue, T., Kanbara, Y., Nishimoto, H., Fujiwara, S., Ogasawara, K. and Ogawa, A.
  • Journal Title: Cerebrovasc Dis Volume: 33 Issue: 6 Pages: 566-573
  • DOI: 10.1159/000338904
  • Peer Reviewed
• [Journal Article] Annual rupture risk of growing unruptured cerebral aneurysms detected by magnetic resonance angiography (2012)
  • Author(s): Inoue, T., Shimizu, H., Fujimura, M., Saito, A. and Tominaga, T.
  • Journal Title: J Neurosurg Volume: 117 Issue: 1 Pages: 20-25
  • DOI: 10.3171/2012.4.jns112225
  • Peer Reviewed
• [Journal Article] Occipital artery-anterior inferior cerebellar artery bypass with microsurgical trapping for exclusively intra-meatal anterior inferior cerebellar artery aneurysm manifesting as subarachnoid hemorrhage. Case report (2012)
  • Author(s): Fujimura, M., Inoue, T., Shimizu, H. and Tominaga, T.
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 52 Pages: 435-438
  • NAID: 10030435221
  • Peer Reviewed
• [Journal Article] Efficacy of Prophylactic Blood Pressure Lowering according to a Standardized Postoperative Management Protocol to Prevent Symptomatic Cerebral Hyperperfusion after Direct Revascularization Surgery for Moyamoya Disease (2012)
  • Author(s): Fujimura, M., Inoue, T., Shimizu, H., Saito, A., Mugikura, S. and Tominaga, T.
  • Journal Title: Cerebrovasc Dis Volume: 33 Pages: 436-445
  • Peer Reviewed
• [Journal Article] Medullary infarction as a poor prognostic factor after internal coil trapping of a ruptured vertebral artery dissection (2012)
  • Author(s): ndo, H., Matsumoto, Y., Kondo, R., Sato, K., Fujimura, M., Inoue, T., Shimizu, H., Takahashi, A. and Tominaga, T.
  • Journal Title: J Neurosurg Volume: 118 Issue: 1 Pages: 131-139
  • DOI: 10.3171/2012.9.jns12566
  • Peer Reviewed
• [Presentation] Quantitative measurement of cerebral blood flow using single photon emission computed tomography with venous blood sampling (2015)
  • Author(s): Inoue T, Shimizu H, Fujimura M, Sato K, Endo H, Niizuma K, Sakata H, Tominaga T
  • Organizer: XXVIIth International Symposium on Cerebral Blood Flow, Metabolism and Function
  • Place of Presentation: Vancouver (Canada)
  • Year and Date: 2015-06-27 – 2015-06-30
• [Presentation] Prediction of the onset day using by T2*-weighted magnetic resonance imaging in patients with subarachnoid (2015)
  • Author(s): Inoue T, Fujimura M, Niizuma K, Tominaga T
  • Organizer: 23rd International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Toronto (Canada)
  • Year and Date: 2015-05-30 – 2015-06-05
• [Presentation] Cerebral blood flow measurement using single photon emission computed tomography with venous blood sampling (2015)
  • Author(s): Inoue T, Fujiwara S, Ezura M, Uenohara H, Fujimura M, Tominaga T
  • Organizer: 24th European Stroke Conference
  • Place of Presentation: Vienna (Austria)
  • Year and Date: 2015-05-13 – 2015-05-15
• [Presentation] CEA術前後にSPECTは必須か？ (2014)
  • Author(s): 井上敬、藤村幹、佐藤健一、遠藤英徳、新妻邦泰、坂田洋之、江面正幸、上之原広司、藤原悟、冨永悌二
  • Organizer: 第26回日本脳循環代謝学会
  • Place of Presentation: 岡山コンベンションセンター（岡山）
  • Year and Date: 2014-11-21 – 2014-11-22
• [Presentation] The rupture risk of growing aneurysms and the adequate follow up interval (2014)
  • Author(s): Inoue T, Fujimura M, Endo H, Fujiwara S, Ezura M, Uenohara H, Tominaga T
  • Organizer: The 12th Korean and Japanese Friendship Conference on Surgery for Cerebral Stroke
  • Place of Presentation: Umeda Sky Building (Osaka)
  • Year and Date: 2014-09-26 – 2014-09-27
• [Presentation] The rupture risk of growing unruptured cerebral aneurysms. (2013)
  • Author(s): Inoue T, Shimizu H, Fujimura M, Endo H, Ezura M, Uenohara H, Tominaga T
  • Organizer: The 6th Korea-Japan Joint Stroke Conference
  • Place of Presentation: Osaka
• [Presentation] 血管内外科時代を迎えた脳動脈瘤手術 (2013)
  • Author(s): 井上敬、冨永悌二
  • Organizer: 第33回日本脳神経外科コングレス
  • Place of Presentation: 大阪
  • Invited
• [Presentation] T2*強調画像による脳動脈瘤破裂時期予測 (2013)
  • Author(s): 井上敬、高田志保美、清水宏明、上之原広司、藤原悟、冨永悌二
  • Organizer: 第41回日本磁気共鳴医学会
  • Place of Presentation: 徳島
• [Presentation] 教育講演21中枢神経急性期脳虚血
  • Author(s): 井上 敬
  • Organizer: 日本画像医学会
  • Place of Presentation: 東京
  • Invited
• [Presentation] ACST,・ACST2 に基づく無症候性頚動脈狭窄症に対する治療選択
  • Author(s): 井上敬
  • Organizer: 脳神経外科東北地方会
  • Place of Presentation: 新潟
• [Presentation] 対側閉塞および両側脳循環予備能低下を認める症候性高度頚動脈狭窄症例に対する治療
  • Author(s): 井上敬
  • Organizer: 脳卒中学会
  • Place of Presentation: 東京
  • Invited
• [Presentation] ３． くも膜下出血転帰不良因子の検討
  • Author(s): 井上敬
  • Organizer: スパズムシンポジウム
  • Place of Presentation: 東京
  • Invited
• [Presentation] The risk of growing and rupture for unruptured cerebral aneurysms
  • Author(s): Takashi Inoue
  • Organizer: Japanese Korean Frendship Conference for Cerebrovascular Surgery
  • Place of Presentation: Korea, Seoul
• [Book] 脳神経外科診療プラクティス (2014)
  • Author(s): 井上敬
  • Total Pages: 286
  • Publisher: 文光堂