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Non-invasive cerebral blood flow and metabolism analysis using by high field magnetic resonance imaging

Research Project

Project/Area Number 24592112
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cerebral neurosurgery
Research InstitutionTohoku University

Principal Investigator

INOUE Takashi  東北大学, 医学(系)研究科(研究院), 非常勤講師 (70326651)

Co-Investigator(Kenkyū-buntansha) TOMINAGA Teiji  東北大学, 大学院医学系研究科, 教授 (00217548)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsMRI / 脳循環代謝 / 非侵襲 / 脳卒中 / 脳血管障害 / 転帰予測 / CBF / SPECT / 定量
Outline of Final Research Achievements

Non-invasive estimation for cerebral blood flow and metabolism using by high field MR imaging was newly developed. Only invasive methods have been sullied for cerebral blood flow and metabolism analysis. We accepted the flow-sensitive attenuated inversion recovery method for estimation to measure cerebral blood flow in patients with stroke. MR spectroscopy was applied for clinical examination to measure brain temperature of patients with stroke. We clarified the utility and limitation for clinical usage of MRI to investigate cerebral blood flow and metabolism.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (31 results)

All 2015 2014 2013 2012 Other

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (13 results) (of which Invited: 4 results) Book (1 results)

  • [Journal Article] Angiographic circulation time and cerebral blood flow during balloon test occlusion of the internal carotid artery.2014

    • Author(s)
      Sato K, Shimizu H, Inoue T, Fujimura M, Matsumoto Y, Kondo R, Endo H, Sonoda Y, Tominaga T.
    • Journal Title

      J Cereb Blood Flow Metab

      Volume: 34 Issue: 1 Pages: 136-143

    • DOI

      10.1038/jcbfm.2013.176

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Maximum preservation of the media in carotid endarterectomy.2014

    • Author(s)
      Niizuma K, Shimizu H, Inoue T, Watanabe M, Tominaga T
    • Journal Title

      Neurol Med Chir

      Volume: 54 Pages: 812-818

    • NAID

      130004690988

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cognard type V intracranial dural arteriovenous shunt: case reports and literature review with special consideration of the pattern of spinal venous drainage.2014

    • Author(s)
      Haryu S, Endo T, Sato K, Inoue T, Takahashi A, Tominaga T
    • Journal Title

      Neurosurgery

      Volume: 74 Issue: 1 Pages: 135-142

    • DOI

      10.1227/neu.0000000000000069

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Case of Bilateral Giant Internal Carotid Artery Aneurysms at the Cavernous Portion Managed by 2-stage Extracranial-Intracranial Bypass with Parent Artery Occlusion: Consideration for Bypass Selection and Timing of Surgeries.2014

    • Author(s)
      Fujimura M, Sato K, Kimura N, Inoue T, Shimizu H, Tominaga T.
    • Journal Title

      Journal of stroke and cerebrovascular diseases

      Volume: 23 Issue: 8 Pages: 393-398

    • DOI

      10.1016/j.jstrokecerebrovasdis.2014.02.020

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Minocycline prevents focal neurological deterioration due to cerebral hyperperfusion after extracranial-intracranial bypass for moyamoya disease2014

    • Author(s)
      Fujimura M, Niizuma K, Inoue T, Sato K, Endo H, Shimizu H, T ominaga T
    • Journal Title

      Neurosurgery

      Volume: 74(2) Issue: 2 Pages: 163-70

    • DOI

      10.1227/neu.0000000000000238

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative assessment of cerebral hemodynamics using single photon emission computed tomography with venous blood sampling.2013

    • Author(s)
      Inoue T, Fujimura M, Shimizu H, Takahashi Y, Tominaga T.
    • Journal Title

      Clin Neurol Neurosurg.

      Volume: 115 Issue: 6 Pages: 684-689

    • DOI

      10.1016/j.clineuro.2012.08.020

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Noninvasive measurement of human brain temperature adjacent to arteriovenous malformation using 3.0 T magnetic resonance spectroscopy2013

    • Author(s)
      Inoue T., Shimizu H., Fujimura M., Saito A., Yoshioka Y., Matsuda T., Tominaga T.
    • Journal Title

      Clinical Neurology and Neurosurgery

      Volume: 115 Issue: 4 Pages: 445-449

    • DOI

      10.1016/j.clineuro.2012.06.022

    • Related Report
      2013 Research-status Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Signal change on T2*-weighted magnetic resonance imaging from the acute to chronic phases in patients with subarachnoid hemorrhage.2013

    • Author(s)
      Inoue T, Takada S, Shimizu H, Niizuma K, Fujimura M, Sato K, Endo H, Tominaga T
    • Journal Title

      Cerebrovasc Dis.

      Volume: 36 Issue: 5-6 Pages: 421-429

    • DOI

      10.1159/000355897

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ruptured aneurysm of a posterior inferior cerebellar artery communicating artery. Case report and histological findings2012

    • Author(s)
      Sugiyama, S., Fujimura, M., Inoue, T., Shimizu, H., Watanabe, M. and Tominaga, T.
    • Journal Title

      Neurol Med Chir (Tokyo)

      Volume: 52 Pages: 81-83

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Temporal profile of de novo development of moyamoya vasculopathy in an adult: case report2012

    • Author(s)
      Shimoda, Y., Fujimura, M., Inoue, T., Shimizu, H. and Tominaga, T.
    • Journal Title

      Neurol Med Chir (Tokyo)

      Volume: 52 Pages: 339-342

    • NAID

      10030314630

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Local hemodynamics at the rupture point of cerebral aneurysms determined by computational fluid dynamics analysis2012

    • Author(s)
      Omodaka, S., Sugiyama, S., Inoue, T., Funamoto, K., Fujimura, M., Shimizu, H., Hayase, T., Takahashi, A. and Tominaga, T.
    • Journal Title

      Cerebrovasc Dis

      Volume: 34 Issue: 2 Pages: 121-129

    • DOI

      10.1159/000339678

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Influence of surface model extraction parameter on computational fluid dynamics modeling of cerebral aneurysms2012

    • Author(s)
      Omodaka, S., Inoue, T., Funamoto, K., Sugiyama, S., Shimizu, H., Hayase, T., Takahashi, A. and Tominaga, T.
    • Journal Title

      J Biomech

      Volume: 45 Issue: 14 Pages: 2355-2361

    • DOI

      10.1016/j.jbiomech.2012.07.006

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prediction of motor function outcome after intracerebral hemorrhage using fractional anisotropy calculated from diffusion tensor imaging2012

    • Author(s)
      Kuzu, Y., Inoue, T., Kanbara, Y., Nishimoto, H., Fujiwara, S., Ogasawara, K. and Ogawa, A.
    • Journal Title

      Cerebrovasc Dis

      Volume: 33 Issue: 6 Pages: 566-573

    • DOI

      10.1159/000338904

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Annual rupture risk of growing unruptured cerebral aneurysms detected by magnetic resonance angiography2012

    • Author(s)
      Inoue, T., Shimizu, H., Fujimura, M., Saito, A. and Tominaga, T.
    • Journal Title

      J Neurosurg

      Volume: 117 Issue: 1 Pages: 20-25

    • DOI

      10.3171/2012.4.jns112225

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Occipital artery-anterior inferior cerebellar artery bypass with microsurgical trapping for exclusively intra-meatal anterior inferior cerebellar artery aneurysm manifesting as subarachnoid hemorrhage. Case report2012

    • Author(s)
      Fujimura, M., Inoue, T., Shimizu, H. and Tominaga, T.
    • Journal Title

      Neurol Med Chir (Tokyo)

      Volume: 52 Pages: 435-438

    • NAID

      10030435221

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of Prophylactic Blood Pressure Lowering according to a Standardized Postoperative Management Protocol to Prevent Symptomatic Cerebral Hyperperfusion after Direct Revascularization Surgery for Moyamoya Disease2012

    • Author(s)
      Fujimura, M., Inoue, T., Shimizu, H., Saito, A., Mugikura, S. and Tominaga, T.
    • Journal Title

      Cerebrovasc Dis

      Volume: 33 Pages: 436-445

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Medullary infarction as a poor prognostic factor after internal coil trapping of a ruptured vertebral artery dissection2012

    • Author(s)
      ndo, H., Matsumoto, Y., Kondo, R., Sato, K., Fujimura, M., Inoue, T., Shimizu, H., Takahashi, A. and Tominaga, T.
    • Journal Title

      J Neurosurg

      Volume: 118 Issue: 1 Pages: 131-139

    • DOI

      10.3171/2012.9.jns12566

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Quantitative measurement of cerebral blood flow using single photon emission computed tomography with venous blood sampling2015

    • Author(s)
      Inoue T, Shimizu H, Fujimura M, Sato K, Endo H, Niizuma K, Sakata H, Tominaga T
    • Organizer
      XXVIIth International Symposium on Cerebral Blood Flow, Metabolism and Function
    • Place of Presentation
      Vancouver (Canada)
    • Year and Date
      2015-06-27 – 2015-06-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Prediction of the onset day using by T2*-weighted magnetic resonance imaging in patients with subarachnoid2015

    • Author(s)
      Inoue T, Fujimura M, Niizuma K, Tominaga T
    • Organizer
      23rd International Society for Magnetic Resonance in Medicine
    • Place of Presentation
      Toronto (Canada)
    • Year and Date
      2015-05-30 – 2015-06-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Cerebral blood flow measurement using single photon emission computed tomography with venous blood sampling2015

    • Author(s)
      Inoue T, Fujiwara S, Ezura M, Uenohara H, Fujimura M, Tominaga T
    • Organizer
      24th European Stroke Conference
    • Place of Presentation
      Vienna (Austria)
    • Year and Date
      2015-05-13 – 2015-05-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] CEA術前後にSPECTは必須か?2014

    • Author(s)
      井上敬、藤村幹、佐藤健一、遠藤英徳、新妻邦泰、坂田洋之、江面正幸、上之原広司、藤原悟、冨永悌二
    • Organizer
      第26回日本脳循環代謝学会
    • Place of Presentation
      岡山コンベンションセンター(岡山)
    • Year and Date
      2014-11-21 – 2014-11-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] The rupture risk of growing aneurysms and the adequate follow up interval2014

    • Author(s)
      Inoue T, Fujimura M, Endo H, Fujiwara S, Ezura M, Uenohara H, Tominaga T
    • Organizer
      The 12th Korean and Japanese Friendship Conference on Surgery for Cerebral Stroke
    • Place of Presentation
      Umeda Sky Building (Osaka)
    • Year and Date
      2014-09-26 – 2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] The rupture risk of growing unruptured cerebral aneurysms.2013

    • Author(s)
      Inoue T, Shimizu H, Fujimura M, Endo H, Ezura M, Uenohara H, Tominaga T
    • Organizer
      The 6th Korea-Japan Joint Stroke Conference
    • Place of Presentation
      Osaka
    • Related Report
      2013 Research-status Report
  • [Presentation] 血管内外科時代を迎えた脳動脈瘤手術2013

    • Author(s)
      井上敬、冨永悌二
    • Organizer
      第33回日本脳神経外科コングレス
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] T2*強調画像による脳動脈瘤破裂時期予測2013

    • Author(s)
      井上敬、高田志保美、清水宏明、上之原広司、藤原悟、冨永悌二
    • Organizer
      第41回日本磁気共鳴医学会
    • Place of Presentation
      徳島
    • Related Report
      2013 Research-status Report
  • [Presentation] 教育講演21中枢神経急性期脳虚血

    • Author(s)
      井上 敬
    • Organizer
      日本画像医学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] ACST,・ACST2 に基づく無症候性頚動脈狭窄症に対する治療選択

    • Author(s)
      井上敬
    • Organizer
      脳神経外科東北地方会
    • Place of Presentation
      新潟
    • Related Report
      2012 Research-status Report
  • [Presentation] 対側閉塞および両側脳循環予備能低下を認める症候性高度頚動脈狭窄症例に対する治療

    • Author(s)
      井上敬
    • Organizer
      脳卒中学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 3. くも膜下出血転帰不良因子の検討

    • Author(s)
      井上敬
    • Organizer
      スパズムシンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] The risk of growing and rupture for unruptured cerebral aneurysms

    • Author(s)
      Takashi Inoue
    • Organizer
      Japanese Korean Frendship Conference for Cerebrovascular Surgery
    • Place of Presentation
      Korea, Seoul
    • Related Report
      2012 Research-status Report
  • [Book] 脳神経外科診療プラクティス2014

    • Author(s)
      井上敬
    • Total Pages
      286
    • Publisher
      文光堂
    • Related Report
      2013 Research-status Report

URL: 

Published: 2013-05-31   Modified: 2019-07-29  

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