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Risk Perception of Unruptured Intracranial Aneurysms

Research Project

Project/Area Number 24592113
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cerebral neurosurgery
Research InstitutionGunma University

Principal Investigator

YOSHIMOTO Yuhei  群馬大学, 医学(系)研究科(研究院), 教授 (50242061)

Co-Investigator(Kenkyū-buntansha) SATO Koji  群馬大学, 医学部, 助教 (60431722)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords未破裂脳動脈瘤 / 生活の質 / マルコフモデル
Outline of Final Research Achievements

Recent prospective studies have shown that the rupture rate of small unruptured intracranial aneurysms is very low. This cross sectional study enrolled 52 patients who had previously been notified of the presence of untreated unruptured aneurysms. A Markov model was constructed to simulate the natural history over time, and the age- and size-specific loss of quality-adjusted life year (QALY) caused by the aneurysms was calculated. Preference-based subjective QALY losses (PSG and PTTO) were assessed using the standard gamble (SG) and time trade-off (TTO) according to patient’s own perceptions. Calculated theoretical QALY losses were relatively small with median values of 0.4 years and 1.9% of expected lifetime. The median values of PSG and PTTO were 10.0% and 19.5%, respectively. Notification of unruptured aneurysms exerts a significant psychological burden and excessively reduces the quality of life relative to the theoretical risks.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (1 results)

All 2014

All Presentation (1 results) (of which Invited: 1 results)

  • [Presentation] 未破裂脳動脈瘤 ~疫学統計の立場から2014

    • Author(s)
      好本 裕平
    • Organizer
      第23回日本脳ドック学会総会 シンポジウム
    • Place of Presentation
      下関
    • Year and Date
      2014-06-06
    • Related Report
      2014 Annual Research Report
    • Invited

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Published: 2013-05-31   Modified: 2019-07-29  

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