Arterial spin labeling MRI measurement is affected by water permeabilty change.

• Project/Area Number: 24592115
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TANAKA YOJI 東京医科歯科大学, 医学部附属病院, 講師 (80323682)
• Co-Investigator(Kenkyū-buntansha): NARIAI Tadashi 東京医科歯科大学, 大学院医師学総合研究科, 准教授 (00228090)
• Co-Investigator(Renkei-kenkyūsha): INAJI Motoki 東京医科歯科大学, 医学部附属病院, 講師 (00422486)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: MRI / arterial spin labeling / cerebral ischemia / blood brain barrier / water permeability / transit time

Outline of Final Research Achievements

Arterial spin labeling (ASL) MRI is a useful method to measure cerebral blood flow (CBF) non-invasively. However, the improvement of quantitativity of ASL is still needed. We evaluated the accuracy of ASL method by comparing with other modalities as positron CT and single photon emission CT. It was clarified that both transit delay and permeability change were the important factors that affected the ASL-CBF differently. Taking into account with these parameters will improve the accuracy of ASL-CBF measurement.

Research Products

• [Journal Article] Practical Clinical Use of Dynamic Susceptibility Contrast Magnetic Resonance Imaging (DSC-MRI) for the Surgical Treatment of Moyamoya Disease. (2014)
  • Author(s): 5. Ishii Y, Nariai T, Tanaka Y, Mukawa M, Inaji M, Maehara T, Ohno K.
  • Journal Title: Neurosurgery Volume: 74（3） Issue: 3 Pages: 302-309
  • DOI: 10.1227/neu.0000000000000266
  • Peer Reviewed
• [Journal Article] 脳神経外科領域における3D ASL撮影の有用性 (2014)
  • Author(s): 田中洋次、成相直、前原健寿
  • Journal Title: GE Today In Technology Volume: 45 Pages: 12-15
• [Journal Article] A fast multiparameter MRI approach for acute stroke assessment on a 3T clinical scanner: preliminary results in a non-human primate model with transient ischemic occlusion (2014)
  • Author(s): 3.Zhang X, Tong F, Li CX, Yan Y, Nair G, Nagaoka T, Tanaka Y, Zola S, Howell L
  • Journal Title: Quant Imaging Med Surg Volume: 4 Pages: 112-122
  • Peer Reviewed
• [Presentation] 脳血管障害合併妊娠例に対するarterial spin labeling MRI計測 (2015)
  • Author(s): 2.田中洋次、成相直、武川麻紀、稲次基希、前原健寿
  • Organizer: 第４０回日本脳卒中学会総会
  • Place of Presentation: 広島市
  • Year and Date: 2015-03-26 – 2015-03-29
• [Presentation] Arterial Spin Labeling MRIを用いた妊婦脳循環計測 (2015)
  • Author(s): 3.田中洋次、成相直、山科元滋、武川麻紀、稲次基希、前原健寿
  • Organizer: 第44回日本神経放射線学会
  • Place of Presentation: 名古屋市
  • Year and Date: 2015-03-06 – 2015-03-07
• [Presentation] 虚血性脳血管障害における脳循環遅延計測の有用性 (2014)
  • Author(s): 田名洋次、成相直、石井洋介、上田泰弘、原祥子、稲次基希、前原健寿
  • Organizer: 第43回日本神経放射線学会
  • Place of Presentation: 米子市 米子コンベンションセンター
• [Presentation] 虚血性脳血管障害における脳循環時間計測の意義 (2014)
  • Author(s): 田中洋次、成相直、石井洋介、上田泰弘、原祥子、稲次基希、前原健寿
  • Organizer: 第37回日本脳神経CI学会
  • Place of Presentation: 大宮市 大宮ソニックシティ
• [Presentation] tility and Limitation of Arterial Spin Labeling MRI Technique for the patient with occlusive cerebrovascular disease. (2013)
  • Author(s): 2. Tanaka Y, Nariai T, Hara S, Ueda Y, Inaji M, Ishii Y, Maehara T.
  • Organizer: Congress of Neurological Surgeons 2013 Annual Meeting,
  • Place of Presentation: San Francisco, USA
• [Presentation] Arterial spin labeling法MRI撮影による閉塞性脳血管障害の脳血流評価 (2012)
  • Author(s): 田中洋次，成相直、稲次基希、上田泰弘、大野喜久郎
  • Organizer: 第37回日本脳卒中学会総会
  • Place of Presentation: 福岡県
• [Presentation] Arterial spin labeling 法MRI撮影による脳血流の至適定量的評価法の探求 (2012)
  • Author(s): 田中洋次、成相直、上田泰弘、原祥子、稲次基希、青柳傑、大野喜久郎
  • Organizer: 第71回日本脳神経外科学会総会
  • Place of Presentation: 大阪府