Investigation for early epileptogenetic features of human cortical tissues

• Project/Area Number: 24592116
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Niigata University
• Principal Investigator: OISHI Makoto 新潟大学, 脳研究所, 非常勤講師 (00422593)
• Co-Investigator(Renkei-kenkyūsha): HIRAISHI Tetsuya 新潟大学, 医歯学総合病院, 医員 (80515734) ; KITAURA Hiroki 新潟大学, 脳研究所, 助教 (80401769)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: てんかん原性 / 神経生理 / 大脳皮質 / 神経ネットワーク / てんかん / 病態解明 / 神経科学 / 細胞電位

Outline of Final Research Achievements

To characterize the physiological condition of human epileptic neocortex, we employed flavoprotein fluorescence imaging (FFI) and immunohistologically studied human cortical specimens. We found that correlations between specific FFI findings and decreases in parvalbumin positive neurons may represent an imbalance between excitatory and inhibitory systems in the epileptic neocortex.We believed that the characteristics of human cortical tissues in the early epileptogenetic stage have been visualized by this study.

Research Products

• [Journal Article] Interactive presurgical simulation applying advanced 3D imaging and modeling techniques for skull base and deep tumors. (2013)
  • Author(s): Oishi M, Fukuda M, Yajima N, Yoshida K, Takahashi M, Hiraishi T, Takao T, Saito A, Fujii Y.
  • Journal Title: Journal of Neurosurgery Volume: 119 Issue: 1 Pages: 94-105
  • DOI: 10.3171/2013.3.jns121109
  • Peer Reviewed
• [Journal Article] Significance of horizontal propagation of synchronized activities in human epileptic neocortex investigated by optical imaging and immunohistological study. (2013)
  • Author(s): Hiraishi T, Kitaura H, Oishi M, Fukuda M, Kameyama S, Takahashi H, Kakita A, Fujii Y.
  • Journal Title: Epilepsy Res. Volume: 104 Issue: 1-2 Pages: 59-67
  • DOI: 10.1016/j.eplepsyres.2012.09.014
  • Peer Reviewed
• [Journal Article] Interactive presurgical simulation applying advanced 3D imaging and modeling techniques for skull base and deep tumors. (2013)
  • Author(s): Oishi M, Fukuda M, Yajima N, Yoshida K, Takahashi M, Hiraishi T, Takao T, Saito A, Fujii Y
  • Journal Title: Journal of Neurosurgery Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Periventricular nodular heterotopia functionally couples with the overlying hippocampus. (2012)
  • Author(s): Kitaura H
  • Journal Title: Epilepsia Volume: 53 Issue: 7 Pages: 127-131
  • DOI: 10.1111/j.1528-1167.2012.03509.x
  • Peer Reviewed
• [Presentation] 大脳局所損傷後慢性期の非痙攣性てんかん重積 (2014)
  • Author(s): 大石 誠，三橋大樹，鈴木健司，川口 正
  • Organizer: 第48回 日本てんかん学会
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 2014-10-02 – 2014-10-03
• [Presentation] 局在関連性てんかんにおけるArterial spin labelingによる画像評価 (2014)
  • Author(s): 高尾哲郎，福多真史，大石 誠，平石哲也，藤井幸彦
  • Organizer: 第48回 日本てんかん学会
  • Place of Presentation: 京王プラザホテル
  • Year and Date: 2014-10-02 – 2014-10-03
• [Presentation] 外傷性てんかんに関するレビュー ～臨床・基礎的知見から～
  • Author(s): 大石 誠
  • Organizer: 上中越てんかんネットワーク
  • Place of Presentation: ホテルニューオータニ長岡
• [Presentation] 大脳局所損傷後慢性期に生じた非痙攣性てんかん重積の2症例
  • Author(s): 大石 誠
  • Organizer: 上中越臨床神経疾患研究会
  • Place of Presentation: 長岡中央病院会議室