The neuronal protective and regenerative effects of glucagon-like peptide 1 agonist against transient forebrain ischemia

Research Project

Project/Area Number	24592118
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Cerebral neurosurgery
Research Institution	University of Yamanashi
Principal Investigator	KANEMARU Kazuya 山梨大学, 総合研究部, 講師 (80402080)
Co-Investigator(Kenkyū-buntansha)	HORIKOSHI Tohru 山梨大学, 総合研究部, 医学研究員 (50209300)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	脳虚血 / 神経保護 / 神経再生 / アポトーシス / GLP-1 / exendrin-4 / 神経新生 / 一過性前脳虚血 / apoptosis / neurogenesis / cerebral ischemia / glucagon-like peptide 1
Outline of Final Research Achievements	Elucidating the mechanisms of neuronal apoptosis and its prevention is crucial for the development of a new therapeutic strategy for stroke. Glucagon-like peptide 1 (GLP-1) agonist; exendrin-4 showed a tendency to decrease the amount of apoptosis cells in the CA1 region of the rat hippocampus after transient forebrain ischemia. In addition, the number of Ki67 positive cells tends to increase in the group injected exendrin-4. Thus, theses results suggest that exendrin-4 has neuroprotective effect and regulates neuronal regeneration under physiological and ischemic conditions.