| Project/Area Number |
24592122
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Mie University |
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Principal Investigator |
MATSUSHIMA Satoshi 三重大学, 医学(系)研究科(研究院), リサーチアソシエイト (50252367)
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| Research Collaborator |
MIURA Yoichi 鈴鹿回生病院 (10420390)
HAMADA Kazuhide 桑名西医療センター (00464165)
TOMA Naoki 三重大学, 医学系研究科, 講師 (80362341)
SUZUKI Hidenori 三重大学, 医学系研究科, 教授 (90345976)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 脳動脈瘤 / 脳血管内治療 / 生理活性 / コイル |
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| Outline of Final Research Achievements |
We conduct this study for the aim of evaluating the effects of Gellan sulfate core platinum coil (GSCC) with tenascin-C (TNC) (GSCC-TNC). Elastase-induced rabbit aneurysms were randomly coiled with platinum coils (PCs), GSCCs or GSCC-TNCs and aneurysm-occlusion status was evaluated at 2 weeks post-coiling. In addition, a PC, GSCC or GSCC-TNC was randomly implanted in a rat blind-ended model and the organization effects were immunohistochemically evaluated for expressions of TNC, transforming growth factor-beta (TGF-β) and matrix metalloproteinase-9 (MMP-9) 2 weeks later. As a result, GSCCs showed a significantly higher ratio of organized area to the aneurysmal cavity than PCs. GSCC-TNCs had intense immunoreactivities for TNC, TGF-β and MMP-9 in the organized thrombosis and tunica media.
GSCC-TNCs demonstrated potent aneurysm repair effects in a simulated clinical setting using rabbits possibly through the TGF-β and MMP-9 upregulation.
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