Expression and role of the novel angiogenic regulatory factor Vasohibin-1 in the carotid atherosclerotic plaques
| Project/Area Number |
24592125
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Cerebral neurosurgery
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
YOSHIDA Kazumichi 京都大学, 医学(系)研究科(研究院), 講師 (90598921)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ARAI Hidenori 京都大学, 医学(系)研究科(研究院), 教授 (60232021)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OKADA Tomohisa 京都大学, 医学(系)研究科(研究院), 講師 (30321607)
SATO Yasufumi 東北大学, 加齢医学研究所, 教授 (50178779)
TAKAGI Yasushi 京都大学, 医学(系)研究科(研究院), 准教授 (40312227)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 動脈硬化 / 不安定プラーク / 頚動脈狭窄 / プラーク内出血 / 血管新生調節因子 / バソヒビン / 血管新生 / 分子イメージング |
|---|
| Outline of Final Research Achievements |
It was demonstrated in this study that the expression level of novel angiogenic regulatory factor Vasohibin-1 was significantly higher in carotid atherosclerotic plaque than normal vascular endothelium. There was also significant positive correlation in the expression level between Vasohobin-1 and atherosclerosis-related inflammation markers such as ICAM-1 and VCAM-1. Immunohistochemical investigation revealed that Vasohibin-1 was predominantly expressed in the neovascular endothelium of carotid plaques. These findings strongly suggested the contribution of Vasohibin-1 in the destabilization mechanism of carotid atherosclerosis.
|
Report
(4 results)
Research Products
(5 results)
-
[Journal Article] Expression of Vasohibin-1 in Human Carotid Atherosclerotic Plaque2015
Author(s)
Ryu Fukumitsu, Manabu Minami, Kazumichi Yoshida, Manabu Nagata, Mika Yasui, Sei Higuchi, Risako Fujikawa, Taichi Ikedo, Sen Yamagata, Yasufumi Sato, Hidenori Arai, Masayuki Yokode, Susumu Miyamoto
-
Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 22
Issue: 9
Pages: 942-948
DOI
NAID
ISSN
1340-3478, 1880-3873
Related Report
Peer Reviewed / Open Access
-
-
-
-
