| Project/Area Number |
24592134
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nagasaki University |
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Principal Investigator |
NAGATA Izumi 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (10198327)
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| Co-Investigator(Kenkyū-buntansha) |
SUYAMA Kazuhiko 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (60236057)
HAYASHI Kentaro 長崎大学, 病院(医学系), 講師 (40404222)
HORIE Nobutaka 長崎大学, 病院(医学系), 助教 (70380912)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 脳梗塞 / 頚動脈狭窄 / プラーク / 新生血管 / 頚動脈プラーク / 頸動脈狭窄症 / 頸動脈プラーク / インドシアニングリーン |
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| Outline of Final Research Achievements |
Recent studies have demonstrated plaque morphology to determine high risk patients as well as degree of stenosis in carotid atherosclerosis. Neovascularization of carotid plaques is associated with plaque vulnerability. However, the mechanism of neovascularization for intraplaque hemorrhage (IPH) and its clinical contribution remain undetermined. This study aimed to clarify the characteristics of neovessel appearance focusing on inward neovessels, which has been reported to be important in plaque advancement. Each neovessel pattern was evaluated with respect to clinical, radiological, and pathological findings including IPH, neovascularization, hemosiderin spot and inflammation.
Inward neovessels communicating with lumen and inflammation synergistically contribute to IPH and symptomatic presentation in patients with carotid stenosis, which is more specific than vasa vasorum. This condition could be a new therapeutic target.
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