Strategy of treatment for severe subarachnoid hemorrhage

• Project/Area Number: 24592136
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Kumamoto University
• Principal Investigator: KAI Yutaka 熊本大学, 医学部附属病院, 教授 (30322308)
• Co-Investigator(Kenkyū-buntansha): KURATSU Jyunichi 熊本大学, 大学院生命科学研究部, 教授 (20145296) ; YANO Shigetoshi 熊本大学, 大学院生命科学研究部, 准教授 (60332871) ; OMORI Yuki 熊本大学, 医学部附属病院, 非常勤診療医師 (60599116)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: くも膜下出血 / 脳血管攣縮 / 多角的治療 / クモ膜下出血

Outline of Final Research Achievements

To report the effectiveness of intrathecal selective administration ofurokinase infusion (ITSUKI) therapy delivered via a special kit (ITSUKit),developed to prevent vasospasm in patients with ruptured aneurysms who had undergone Guglielmi detachable coil (GDC) placement, in patients with World Federation of Neurological Surgery (WFNS) grade V subarachnoid hemorrhage (SAH).

Research Products

• [Journal Article] A 6-Fr guiding catheter (Slim Guide®) for use with multiple micro devices (2013)
  • Author(s): Yutaka Kai
  • Journal Title: Interv Neuroradiol Volume: in press
  • Peer Reviewed
• [Journal Article] スパズムの治療 (2012)
  • Author(s): 甲斐 豊
  • Journal Title: Brain Nursing Volume: 28 Pages: 74-78
  • Peer Reviewed
• [Journal Article] A 6-Fr guiding catheter (Slim Guide®) for use with multiple microdevices (2012)
  • Author(s): Yutaka Kai
  • Journal Title: Surgical Neurology International Volume: 3 Pages: 59-64
  • Peer Reviewed
• [Journal Article] Periprocedural Cilostazol Treatment and Restenosis after Carotid Artery Stenting: The Retrospective Study of In-Stent Restenosis after Carotid Artery Stenting ReSISteR-CAS) (2012)
  • Author(s): Yamagami H, Sakai N, Matsumaru Y, Sakai C, Kai Y, Sugiu K, Fujinaka T, Matsumoto Y, Miyachi S, Yoshimura S, Hyogo T, Kuwayama N, Hyodo A
  • Journal Title: J Stroke Cerebrovasc Volume: 3 Pages: 193-199
  • Peer Reviewed
• [Journal Article] Hyperperfusion Syndrome After Stent Placement for Subclavian Artery Stenosis (2012)
  • Author(s): Koichi Ito, Hirokatsu Yonaha, Yutaka Kai, Yohei Hokama, Hideki Nagamine, Tomoo Miyagi, Takashi Watanabe, Shogo Ishiuchi
  • Journal Title: Neurol Med Chir (Tokyo) Volume: 52 Pages: 902-905
  • Peer Reviewed
• [Presentation] A 6-Fr guiding catheter (Slim Guide) for use with multiple micro devices (2012)
  • Author(s): Yutaka Kai, Yasuyuki Kaku, Yuki Ohmori, Takayuki Kawano, Motohiro Morioka, Junichiro Hamada, Jun-ichi Kuratsu
  • Organizer: The 10th meeting of Asian-Australasian Federation of Interventional and Therapeutic Neuroradiology
  • Place of Presentation: Nagoya, Japan (名古屋国際会議場）
• [Presentation] A 6-F guiding catheter (Slim Guide) for use with multiple micro devices (2012)
  • Author(s): Yutaka Kai, Yasuyuki Kaku, Yuki Ohmori, Takayuki Kawano, Motohiro Morioka, Junichiro Hamada, Jun-ichi Kuratsu
  • Organizer: The 10th meeting of Asian-Australasian Federation of Interventional and Therapeutic Neuroradiology
  • Place of Presentation: Nagoya, Japan （名古屋国際会議場）
• [Presentation] Dissecting aneurysms of the vertebral artery - Angiographic patterns at the dissecting site on balloon test occlusion - (2012)
  • Author(s): Yutaka Kai, Yasuyuki Kaku, Yuki Ohmori, Takayuki Kawano, Motohiro Morioka, Junichiro Hamada, Jun-ichi Kuratsu
  • Organizer: 80thAmerican Association of Neurosurgical Surgeons
  • Place of Presentation: Miami, USA (Miami Convention Center)
• [Presentation] Dissecting Aneurysms of the Vertebral Artery - Angiographic Patterns at the Dissecting Site on Balloon Test Occlusion (2012)
  • Author(s): Yutaka Kai, Yuki Ohmori, Takayuki Kawano, Jun-ichi Kuratsu
  • Organizer: The 4th Annual International Congress of Cardiology
  • Place of Presentation: Guangzhou, China (Guangzhou Convention Center)
• [Presentation] 解離性椎骨動脈瘤に対するバルーン閉塞試験により発症形式の予測可能か？ (2012)
  • Author(s): 甲斐 豊、大森雄樹、河野隆行、倉津純一
  • Organizer: 第37回日本脳卒中学会総会
  • Place of Presentation: 福岡 （福岡国際会議場）
• [Presentation] コイル塞栓術後に巨大化した血栓化脳動脈瘤症例の検討 (2012)
  • Author(s): 甲斐 豊、大森雄樹、河野隆行、倉津純一
  • Organizer: 第41回日本脳卒中の外科学会
  • Place of Presentation: 福岡（福岡国際会議場）
• [Presentation] 遠隔診断を用いた超急性期脳梗塞治療の展望 (2012)
  • Author(s): 甲斐 豊、大森雄樹、河野隆行、倉津純一
  • Organizer: 第20回 CVD - TRAK meeting
  • Place of Presentation: 熊本 （熊本大学医学部図書棟）
• [Presentation] 遠隔診断を用いた超急性期脳梗塞治療の展望 (2012)
  • Author(s): 甲斐 豊、大森雄樹、河野隆行、倉津純一
  • Organizer: 第６回 熊本ストローク研究会
  • Place of Presentation: 熊本 （日航ホテル熊本）
• [Presentation] 新しい6Fr.ガイディングカテーテルSlim Guide®の有用性の検討- 2本のマイクロカテーテルシステムを留置するために - (2012)
  • Author(s): 甲斐 豊、大森雄樹、河野隆行、倉津純一
  • Organizer: 第７１回 日本脳神経外科学会総会
  • Place of Presentation: 大阪 （大阪国際会議場）
• [Presentation] 遠隔診断を用いた超急性期脳梗塞治療の展望 (2012)
  • Author(s): 甲斐 豊、大森雄樹、河野隆幸、倉津純一
  • Organizer: 第２８回 日本脳神経血管内治療学会
  • Place of Presentation: 仙台 （仙台国際会議場）
• [Book] 第106回医師国家試験解説集 (2012)
  • Author(s): 甲斐 豊
  • Publisher: メディックメディア社
• [Book] イヤーノート内科外科編 2013年度版 (2012)
  • Author(s): 甲斐 豊
  • Publisher: 医療情報科学研究所
• [Book] まるごと一冊！脳梗塞、外科療法と血管内治療、脳血栓回収療法 (2012)
  • Author(s): 甲斐 豊
  • Publisher: Brain Nursing
• [Book] まるごと一冊！脳梗塞, 外科療法と血管内治療、頸動脈ステント留置術 (2012)
  • Author(s): 甲斐 豊
  • Publisher: Brain Nursing
• [Book] レビューブック 必修・禁忌 第2版. 神経・運動器疾患 (2012)
  • Author(s): 甲斐 豊
  • Publisher: メディックメディア社